Synonyms
Definition
Minimally invasive adenocarcinoma (MIA) is a localized lesion showing a predominantly lepidic (bronchioloalveolar) growth pattern of adenocarcinoma but with an area of invasive adenocarcinoma no more than 5 mm in maximum diameter. MIA lesions are generally less than 30 mm in diameter, although size is not a limitation to diagnosis per se.
Clinical Features
Incidence
Since the concept of MIA, with criteria for its diagnosis was established very recently and introduced in the 2015 WHO lung cancer classification, there are very limited data on its prevalence. It is a rare lesion, with similar prevalence to AIS and much less common than invasive adenocarcinoma. One large Chinese study reported MIA in 4% of nearly 2300 adenocarcinoma cases. MIA is likely to be overrepresented in any case series based upon a lung cancer screening program using high-resolution computed tomography (HRCT). In one such series, also from China, MIA comprised 17% of...
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References and Further Readings
Behera, M., Owonikoko, T. K., Gal, A. A., et al. (2016). Lung adenocarcinoma staging using the 2011 IASLC/ATS/ERS classification: A pooled analysis of adenocarcinoma in situ and minimally invasive adenocarcinoma. Clinical Lung Cancer, 17(5), e57–e64.
Naito, M., Aokage, K., Saruwatari, K., et al. (2016). Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung. Lung Cancer, 100, 53–62.
Nakamura, H., Koizumi, H., Kimura, H., et al. (2016). Epidermal growth factor receptor mutations in adenocarcinoma in situ and minimally invasive adenocarcinoma detected using mutation-specific monoclonal antibodies. Lung Cancer, 99, 143–147.
Qiu, Z. X., Cheng, Y., Liu, D., et al. (2016). Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography. Therapeutics and Clinical Risk Management, 12, 1445–1453.
Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.
Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.
Yu, Y., Ding, Z., Zhu, L., et al. (2016). Frequencies of ALK rearrangements in lung adenocarcinoma subtypes: A study of 2299 Chinese cases. Spring, 5(1), 894.
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Kerr, K.M. (2017). Minimally Invasive Adenocarcinoma (MIA). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4773-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4773-1
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Publisher Name: Springer, Cham
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