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Carcinoma: Cylindrical Cell

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  • First Online:
Head and Neck Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Non-keratinizing squamous cell carcinoma; Ringertz’ carcinoma; Schneiderian carcinoma; Transitional cell carcinoma

Definition

Cylindrical cell carcinoma (CCC) is a distinctive sinonasal tumor derived from sinonasal respiratory (schneiderian) epithelium, formed by nests and ribbons of non-keratinizing epithelial cells, with predominant cylindrical shape, often arranged perpendicularly to the basement membrane. CCC is considered by the current WHO classification as a variant of squamous cell carcinoma (Pilch et al. 2005). Others, however, consider it as a separate clinicopathologic entity, based on observations that the tumors are more sensitive to radiation therapy and have less tendency to spread via lymphatics than the conventional squamous cell carcinoma. CCC may develop from inverted and oncocytic Schneiderian papillomas.

Clinical Features

  • Incidence

    CCC is a rare tumor. It represented approximately 20 % of all sinonasal carcinomas seen at the Royal National Throat, Nose and...

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References and Further Reading

  • Alos, L., Moyano, S., Nadal, A., et al. (2009). Human papilloma viruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome. Cancer, 115, 2701–2709.

    Article  PubMed  Google Scholar 

  • Blanco, A. I., Chao, K. S., Ozyigit, G., Adli, M., Thorstad, W. L., Simpson, J. R., Spector, G. J., Haughey, B., & Perez, C. A. (2004). Carcinoma of paranasal sinuses: Long-term outcomes with radiotherapy. International Journal of Radiation Oncology, Biology, and Physics, 59, 51–58.

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  • Day, T. A., Beas, R. A., Schlosser, R. J., Woodworth, B. A., Barredo, J., Sharma, A. K., & Gillespie, M. B. (2005). Management of paranasal sinus malignancy. Current Treatment Options in Oncology, 6, 3–18.

    Article  PubMed  Google Scholar 

  • El-Mofty, S. K., & Lu, D. W. (2005). Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: A distinct clinicopathologic and molecular disease entity. The American Journal of Surgical Pathology, 29, 1367–1372.

    Article  PubMed  Google Scholar 

  • Osborn, D. A. (1970). Nature and behavior of transitional tumors in the upper respiratory tract. Cancer, 25, 50–60.

    Article  CAS  PubMed  Google Scholar 

  • Pilch, B. Z., Bouquot, J., & Thompson, L. D. R. (2005). Squamous cell carcinoma. In L. Barnes, J. W. Eveson, P. Reichart, & D. Sidranski (Eds.), Head and neck tumours. WHO classification of tumours (pp. 15–17). Lyon, France: IARC Press.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Section of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy

    Alessandro Franchi

  2. Section of Histopathology, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy

    Annarita Palomba

Authors
  1. Alessandro Franchi
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  2. Annarita Palomba
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Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia

    Metka Volavšek

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© 2016 Springer International Publishing Switzerland

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Franchi, A., Palomba, A. (2016). Carcinoma: Cylindrical Cell. In: Volavšek, M. (eds) Head and Neck Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28618-1_1771

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  • DOI: https://doi.org/10.1007/978-3-319-28618-1_1771

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28617-4

  • Online ISBN: 978-3-319-28618-1

  • eBook Packages: MedicineReference Module Medicine

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