Synonyms
Meniere disease
Definition
Meniere’s Disease (MD) is a disorder of the inner ear clinically characterized by intermittent episodes of vertigo, tinnitus and fluctuating sensorineural hearing loss. The pathogenesis of MD has been related for long time to hydrops of the endolymphatic spaces, due to excessive fluid retention. More recently it has been suggested that MD may be a common end stage of several conditions, including ischemic or autoimmune disorders (Berlinger 2011). Up to 15 % of cases of MD are familial following an autosomal dominant mode of inheritance with incomplete penetrance. A candidate gene region for MD has been identified on chromosome 12p12.3 using linkage analysis (Klar et al. 2006).
Clinical Features
Incidence
The incidence of MD has varied between 15 per 100.000 persons in the United States of America to 157 per 100,000 in the UK (Sajjadi and Paparella 2008).
Age
The peak age for MD is between 40 and 60 years. MD has also been reported in the pediatric...
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References and Further Reading
Balkany, T. J., Sires, B., & Arenberg, I. K. (1980). Bilateral aspects of Meniere’s disease: An underestimated clinical entity. Otolaryngologic Clinics of North America, 13, 603–609.
Berlinger, N. T. (2011). Meniere disease. New concepts, new treatments. Minnesota Medicine, 94, 33–36.
Danckwardt-Lillieström, N., Friberg, U., Kinnefors, A., & Rask-Andersen, H. (1997). “Endolymphaticsacitis” in a case of active Menière’s disease. An ultrastructuralhistopathologic investigation. The Annals of Otology, Rhinology, and Laryngology, 106, 190–198.
Gacek, R. R., & Gacek, M. R. (2011). Meniere’s disease as a manifestation of vestibular ganglionitis. American Journal of Otolaryngology, 22, 241–250.
Klar, J., Frykholm, C., Friberg, U., & Dahl, N. (2006). A Meniere’s disease gene linked to chromosome 12p12.3. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141B, 463–467.
Meyerhoff, W. L., Paparella, M. M., & Shea, D. (1978). Ménière’s disease in children. Laryngoscope, 88, 1504–1511.
Rauch, S. D., Merchant, S. N., & Thedinger, B. A. (1989). Meniere’s syndrome and endolymphatichydrops. Double-blind temporal bone study. The Annals of Otology, Rhinology, and Laryngology, 98, 873–883.
Sajjadi, H., & Paparella, M. M. (2008). Meniere’s disease. Lancet, 372, 406–414.
Tsuji, K., Velázquez-Villaseñor, L., Rauch, S. D., Glynn, R. J., Wall, C., 3rd, & Merchant, S. N. (2000). Temporal bone studies of the human peripheral vestibular system. Meniere’s disease. The Annals of Otology, Rhinology & Laryngology. Supplement, 181, 26–31.
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Franchi, A., Palomba, A. (2016). Meniere’s Disease. In: Volavšek, M. (eds) Head and Neck Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28618-1_1726
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DOI: https://doi.org/10.1007/978-3-319-28618-1_1726
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