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Cheilitis Granulomatosa

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  • First Online:
Dental and Oral Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 73 Accesses

Synonyms

Cheilitis granulomatosis of Miescher; Orofacial granulomatosis of the lip

Definition

Cheilitis granulomatosa, first described by Miescher in 1945, is together with Melkersson-Rosenthal syndrome subsets of orofacial granulomatosis. Clinically, patients present with a non-tender, persistent swelling of one or both lips. The labial swelling may be associated with orofacial swelling affecting the chin, eyelids, cheeks, gingiva, and oral mucosa.

Clinical Features

  • Incidence

    It is estimated that the incidence is 0.08 % in the population.

  • Age

    Mostly adults, although it can occur in childhood. In children and adults under 30 years of age, an association with an asymptomatic, non-Crohn’s disease, gastrointestinal inflammatory process, or food allergy has been shown.

  • Sex

    Cheilitis granulomatosa has a female predilection.

  • Site

    Upper and lower lip.

  • Treatment

    First, try to find the underlying cause by thorough clinical examination. Individual lesions have been treated with several different...

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References and Further Reading

  • El-Hakim, M., & Chauvin, P. (2004). Orofacial granulomatosis presenting as persistent lip swelling: review of 6 new cases. Journal of Oral and Maxillofacial Surgery, 62, 1114–1117.

    Article  PubMed  Google Scholar 

  • Kaminagakura, E., & Jorge, J. Jr. (2011). Melkersson Rosenthal syndrome: A histopathologic mystery and dermatologic challenge. Journal of Cutaneous Pathology, 38, 241–245.

    Google Scholar 

  • van der Waal, R. I. F., Schulten, E. A. J. M., van der Scheur, M. R., Wauters, I. M. P. M. J., Starink, T. M., & van der Waal, I. (2001). Cheilitis granulomatosa. Journal of the European Academy of Dermatology & Venereology, 15, 519–523.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Martini Hospital, 30033, 9700 RM, Groningen, Netherlands

    Jacqueline E. van der Wal

Authors
  1. Jacqueline E. van der Wal
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Corresponding author

Correspondence to Jacqueline E. van der Wal .

Editor information

Editors and Affiliations

  1. Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

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© 2016 Springer-Verlag Berlin Heidelberg

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van der Wal, J.E. (2016). Cheilitis Granulomatosa. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28085-1_667

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  • DOI: https://doi.org/10.1007/978-3-319-28085-1_667

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28084-4

  • Online ISBN: 978-3-319-28085-1

  • eBook Packages: MedicineReference Module Medicine

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