The Stress Response of Critical Illness: Metabolic and Hormonal Aspects

1. Front Matter

   Pages i-viii

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2. Introduction

   • Jean-Charles Preiser

   Pages 1-2

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3. Metabolic Changes

   1. Front Matter

      Pages 3-3

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   2. Successive Phases of the Metabolic Response to Stress

      • Jean-Charles Preiser, Carole Ichai, A. B. Johan Groeneveld

      Pages 5-18

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   3. Bioenergetics of the Stress Response

      • Christophe Faisy

      Pages 19-26

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   4. Mitochondrial Adaptation and Hibernation

      • Jonathan Grip, Nicolas Tardif, Olav Rooyackers

      Pages 27-43

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   5. Anabolic Resistance

      • Jean-Paul Thissen

      Pages 45-60

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   6. Use of Lipids as Energy Substrates

      • Philip C. Calder, Pierre Singer

      Pages 61-74

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   7. The Stress Response of Critical Illness: Metabolic and Hormonal Aspects

      • Luc Tappy

      Pages 75-87

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   8. Stress Hyperglycemia

      • Jean-Charles Preiser, Aurélie Thooft, Rafael Machado Tironi

      Pages 89-94

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   9. Protein Metabolism

      • Åke Norberg, Felix Liebau, Jan Wernerman

      Pages 95-106

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   10. Micronutrients

       • Mette M. Berger

       Pages 107-122

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4. Hormonal Regulation

   1. Front Matter

      Pages 123-123

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   2. Thyroidal Changes During Critical Illness

      • Lies Langouche, Greet Van den Berghe

      Pages 125-136

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   3. Stress Response: Adrenal Function

      • Paul E. Marik

      Pages 137-152

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   4. Enterohormones and the Response to Critical Illness

      • Mark P. Plummer, Annika Reintam Blaser, Adam M. Deane

      Pages 153-168

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   5. Adipokines in Critical Illness

      • Katherine Robinson, John Prins, Bala Venkatesh

      Pages 169-183

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5. Particular Clinical Situations

   1. Front Matter

      Pages 185-185

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   2. Severe Undernutrition

      • Pierre Singer, Jonathan Cohen

      Pages 187-195

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   3. The Stress Response after Traumatic Brain Injury: Metabolic and Hormonal Aspects

      • Hervé Quintard, Carole Ichai, Jean-Francois Payen

      Pages 197-206

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This book demonstrates how the latest insights into the physiopathology of the stress response can be integrated into clinical practice. The topic is particularly relevant since the metabolic changes triggered by acute stress, including adaptive responses such as resistance to anabolic signals, have recently been more precisely delineated. The underlying mechanisms of these changes are also now better understood. The authors analyse how these advances could result in better management and more effective prevention of the long-term clinical consequences of the alterations occurring during the acute phase. An international panel of respected experts discusses these topics and describes the management of some common clinical conditions.

• Acute stress
• Anesthesiology
• Endocrine response
• Intensive care medicine
• Translational research
• metabolic disease

“The last decade has seen dramatic evolution in our understanding of the metabolic response to critical illness and its management. This book provides a summary of this work. Senior trainees in critical care or practitioners in high acuity units are an appropriate audience for this book, written by authors from Europe and North America. … This is a worthy summary of the recent work in metabolic and endocrine response to various insults.” (David J. Dries, Doody’s Book Reviews, July, 2016)

• Brussels, Belgium

  Jean-Charles Preiser

Jean-Charles Preiser is currently Professor at the Department of Intensive Care of the Erasme University Hospital in Brussels. He has a long-lasting involvement in clinical research, in relation with the metabolic and nutritional aspects of critical illness. He published about 200 peer-reviewed articles, guidelines and book chapters. He is currently the associate editor of the Journal of Parenteral and Enteral Nutrition (JPEN), Critical Care and The Annals of Intensive Care and is actually involved in international and national education programs on nutrition.

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