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Tumors of Osseous and Chondroid Cell Lineages

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Apart from mixed epithelial and mesenchymal hepatoblastomas, which commonly produce osteoid, hepatic neoplasms with osteogenic or chondroid differentiation are very rare lesions. True osteoma of the liver has apparently not been documented. In contrast, primary osteosarcoma of the liver is a well-documented, albeit rare malignancy that is diagnosed in older patients. It presents as pure neoplasms or mixed tumors (carcinosarcomas) with osteoid components. Pure hepatic osteosarcoma forms tumor of very large size, lesions sometimes exceeding a weight of 3000 g. Histology corresponds to that of skeletal osteosarcoma, with variable amounts of calcified tumor osteoid. Part of the neoplasms contain multinucleated tumor giant cells. Primary chondroma of the liver is an exceptional neoplasm, while primary hepatic tumors with a chondrosarcomatous component have more often been described. The differential diagnosis of these lesions mainly consists of metastatic liver disease, both osteosarcomas and chondrosarcomas metastasizing to the liver.

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Authors and Affiliations

  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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  1. Arthur Zimmermann
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Zimmermann, A. (2016). Tumors of Osseous and Chondroid Cell Lineages. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26587-2_66-1

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  • DOI: https://doi.org/10.1007/978-3-319-26587-2_66-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-26587-2

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