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Benign/Borderline Epithelial Tumors and Dysplastic Alterations of the Gallbladder

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

The gallbladder epithelium can give rise to a spectrum of adenomatous, borderline, and dysplastic lesions. Adenomas of the gallbladder are benign neoplasms of the glandular epithelium, often with various forms of differentiation. These tumors are usually small and solitary lesions that are asymptomatic in the majority of cases and often associated with cholelithiasis. Tubular, papillary, and tubulopapillary growth patterns are distinguished. Differentiation patterns include biliary type, pyloric-gland type, intestinal type, and foveolar type. Part of these neoplasms can contain Paneth cells, keratinocytes, neuroendocrine cells, or oncocytes. One special form is characterized by a solitary or diffuse papillary growth (gallbladder papilloma), a lesion sometimes associated with papillomatosis of the cystic duct and extrahepatic bile ducts. A small subset of preinvasive neoplastic gallbladder polyps show a complex mixture of papillary and tubular patterns and are termed intracholecystic papillary-tubular neoplasm.

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    Arthur Zimmermann

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Zimmermann, A. (2016). Benign/Borderline Epithelial Tumors and Dysplastic Alterations of the Gallbladder. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26587-2_153-1

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