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Adenocarcinoma of the Gallbladder (Classical Gallbladder Cancer)

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

Abstract

Ordinary gallbladder carcinoma (adenocarcinoma) develops in a gallbladder that has undergone secondary changes, often due to long-standing cholelithiasis and associated alterations. Gallbladder carcinoma is detected in about 2–3 % of all cholecystectomy samples and accounts to approximately 60 % of all cancers of the extrahepatic biliary system. The neoplasm can be associated with epithelial precursor lesions and presents with various macroscopic growth patterns. Part of the tumors show, similar to cholangiocarcinomas, a marked desmoplastic stromal reaction and cause a circumscribed or diffuse thickening of the gallbladder wall. Other tumors grow a nodular lesion, sometimes large and obstructing the gallbladder lumen, or present in the form of polyps that grow into the lumen. Histologically, most of the neoplasms are glandular adenocarcinomas with various levels of cellular differentiation. The tumors can grow through the gallbladder wall, show perineural invasion, extend into the gallbladder bed, and invade, depending on stage, into the liver and adjacent organs.

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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  1. Arthur Zimmermann
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Zimmermann, A. (2016). Adenocarcinoma of the Gallbladder (Classical Gallbladder Cancer). In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26587-2_147-1

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  • DOI: https://doi.org/10.1007/978-3-319-26587-2_147-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-26587-2

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