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Angiogenesis Inhibition in Breast Cancer

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Breast Disease

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Abstract

Angiogenesis plays an essential role in tumor development, invasion, and metastasis. In preclinical models, agents that block the vascular endothelial growth factor (VEGF) pathway have been shown to effectively inhibit tumor angiogenesis and growth. Although antiangiogenic therapies, including anti-VEGF antibodies and tyrosine kinase inhibitors, have become important components of the standard of care for the treatment of many solid tumors, the results of clinical trials investigating the efficacy of antiangiogenic agents in breast cancer are contradictory. In this chapter, the importance of angiogenesis inhibition in breast cancer is discussed in light of recent clinical data.

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  2. Gokhan Demir MD
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Correspondence to Kerem Okutur MD .

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  1. Inst of Oncology,Ist Tıp Fak, Istanbul University, Istanbul, Turkey

    Adnan Aydiner

  2. General Surgery, Istanbul Univ Istanbul Fac of Med, Istanbul, Turkey

    Abdullah İgci

  3. Breast Surgery,, Magee-Womens Hospital, Pittsburg, USA

    Atilla Soran

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© 2016 Springer International Publishing Switzerland

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Okutur, K., Demir, G. (2016). Angiogenesis Inhibition in Breast Cancer. In: Aydiner, A., İgci, A., Soran, A. (eds) Breast Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-26012-9_35

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  • DOI: https://doi.org/10.1007/978-3-319-26012-9_35

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26010-5

  • Online ISBN: 978-3-319-26012-9

  • eBook Packages: MedicineMedicine (R0)

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