Skip to main content
SpringerLink
Log in

l-Arginine in Cancer Therapy

  • Chapter
  • First Online:
L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

  • 1398 Accesses

Abstract

One method of treating certain cancers is by amino acid depletion. The best example of this is asparaginase, which has been used to lower blood levels of asparagine, a nonessential amino acid in humans. Asparaginase has been used for years to treat acute lymphoblastic leukemia, the most common form of leukemia in children and young adults. Since most human body cells do not require asparagine for their growth and survival, whereas the leukemic cells are auxotrophic for this amino acid, this represents a targeted approach to treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lieberman I, Ove P. Biochim Biophys Acta. 1960;38:153.

    Article  CAS  PubMed  Google Scholar 

  2. Freed JJ, Sorof S. Biochem Biophys Res Commun. 1966;22(1):1.

    Article  CAS  PubMed  Google Scholar 

  3. Freed JJ, Schatz SA. Exp Cell Res. 1969;55(3):393.

    Article  CAS  PubMed  Google Scholar 

  4. Holley RW. Biochim Biophys Acta. 1967;145(2):525.

    Article  CAS  PubMed  Google Scholar 

  5. Storr JM, Burton AF. Br J Cancer. 1974;30(1):50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Takaku H, Takase M, Abe S, et al. Int J Cancer. 1992;51(2):244.

    Article  CAS  PubMed  Google Scholar 

  7. Sugimura K, Fukuda S, Wada Y, et al. Infect Immun. 1990;58(8):2510.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Savoca KV, Davis FF, van Es T, et al. Cancer Biochem Biophys. 1984;7(3):261.

    CAS  PubMed  Google Scholar 

  9. Lam TL, Wong GK, Chow HY, et al. Pigment Cell Melanoma Res. 2011;24(2):366.

    Article  CAS  PubMed  Google Scholar 

  10. Glazer ES, Stone EM, Zhu C, et al. Transl Oncol. 2011;4(3):138.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cheng PN, Leung YC, Lo WH, et al. Cancer Lett. 2005;224(1):67.

    Article  CAS  PubMed  Google Scholar 

  12. Yau T, Cheng PN, Chan P, et al. Invest New Drugs. 2013;31(1):99.

    Article  CAS  PubMed  Google Scholar 

  13. Dillon BJ, Prieto VG, Curley SA, et al. Cancer. 2004;100(4):826.

    Article  CAS  PubMed  Google Scholar 

  14. Tang SW, Chang WH, Chao YW, et al. J Biomed Sci. 2006;13(2):233.

    Article  CAS  PubMed  Google Scholar 

  15. Curley SA, Bomalaski JS, Ensor CM, et al. Hepato-gastroenterology. 2003;50(53):1214.

    PubMed  Google Scholar 

  16. Izzo F, Marra P, Beneduce G, et al. J Clin Oncol. 2004;22(10):1815.

    Article  CAS  PubMed  Google Scholar 

  17. Delman KA, Brown TD, Thomas M, et al. J Clin Oncol ASCO Annu Meet Proc. 2005;23:16S.

    Google Scholar 

  18. Yang TS, Lu SN, Chao Y, et al. Br J Cancer. 2010;103(7):954.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Szlosarek PW, Luong P, Phillips MM, et al. J Clin Oncol. 2013;31(7):e111.

    Article  PubMed  Google Scholar 

  20. Ascierto PA, Scala S, Castello G, et al. J Clin Oncol. 2005;23(30):7660.

    Article  CAS  PubMed  Google Scholar 

  21. Feun LG, Marini A, Walker G, et al. Br J Cancer. 2012;106(9):1481.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Ott PA, Carvajal RD, Pandit-Taskar N, et al. Invest New Drugs. 2013;31(2):425.

    Article  CAS  PubMed  Google Scholar 

  23. Mauldin JP, Zeinali I, Kleypas K, et al. Transl Oncol. 2012;5(1):26.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Agrawal V, Woo JH, Mauldin JP, et al. Anticancer Drugs. 2012;23(1):51.

    Article  CAS  PubMed  Google Scholar 

  25. Groneberg DA, Giersig M, Welte T, et al. Curr Drug Targets. 2006;7(6):643.

    Article  CAS  PubMed  Google Scholar 

  26. Farokhzad OC, Langer R. Adv Drug Deliv Rev. 2006;58(14):1456.

    Article  CAS  PubMed  Google Scholar 

  27. Savaraj N, You M, Wu C, et al. Curr Mol Med. 2010;10(4):405.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Kim RH, Bold RJ, Kung HJ. Autophagy. 2009;5(4):567.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. You M, Savaraj N, Kuo MT, et al. Mol Cell Biochem. 2013;374(1-2):181.

    Article  CAS  PubMed  Google Scholar 

  30. Feun LG, Wu C, Lee S, et al. Proc Am Assoc Cancer Res Los Angeles CA USA. 2007;48:4042.

    Google Scholar 

  31. Li YY, Wu CW, Chen SM, et al. Proc Am Assoc Cancer Res San Diego CA USA. 2014;55:892.

    Google Scholar 

  32. Tsai WB, Aiba I, Lee SY, et al. Mol Cancer Ther. 2009;8(12):3223.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, 33136, USA

    Lynn G. Feun MD

  2. Sylvester Comprehensive Cancer Center, University of Miami and VA Medical Center, 1201 NW 16th Street, Miami, FL, 33125-1624, USA

    Medhi Wangpaichitr PhD

  3. VA Medical Center, University of Miami, 1201 NW 16th Street, Miami, FL, 33125-1624, USA

    Chunjing Wu MS, Ying-Ying Li MS & Min You PhD

  4. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 West Holcombe, Houston, TX, 77030, USA

    Macus Tien Kuo PhD

  5. Hematology-Oncology Section, VA Medical Center, Sylvester Comprehensive Cancer Center, 1201 N.W. 16th Street, Miami, FL, 33125, USA

    Niramol Savaraj MD

Authors
  1. Lynn G. Feun MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Medhi Wangpaichitr PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chunjing Wu MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ying-Ying Li MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Min You PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Macus Tien Kuo PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Niramol Savaraj MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lynn G. Feun MD .

Editor information

Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Feun, L.G. et al. (2017). l-Arginine in Cancer Therapy. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_43

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26009-9_43

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation