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Pediatric Immunology

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Introduction to Molecular Vaccinology

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Abstract

Newborn’s immune system is not nearly as effective as an adult’s or even an older child’s, and it takes many months before a newborn can fight off infection as well as someone whose immune system is fully matured. In the meantime, pregnant mothers pass immunoglobulin antibodies from their bloodstream, through the placenta, and to the fetus. These antibodies are an essential part of the fetus’s immune system. Passive transfer of maternal antibodies occurs after the 28th week of gestation. Premature infants of less than 28 weeks gestation are not expected to have significant amounts of maternal antibody and are especially vulnerable to serious bacterial infection, as well as some viral and fungal infections. The fetal immune system develops in a sterile and protected environment and therefore lacks antigenic experience.

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  1. Institute for Molecular Vaccines, Heidelberg, Germany

    Matthias Giese

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Giese, M. (2016). Pediatric Immunology. In: Introduction to Molecular Vaccinology. Springer, Cham. https://doi.org/10.1007/978-3-319-25832-4_4

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