Abstract
According to the classification of the National Institutes of Health (NIH), class III CP/chronic pelvic pain syndrome (CP/CPPS) is the most frequent category, in which either genitourinary symptoms or pain is usually present and the impact on the quality of life is considerable. The efficacies of current therapies for CP/CPPS are unsatisfactory. Phytotherapeutics are a noteworthy option due to their generally minimal side effects; however, few have been subjected to scientific scrutiny and prospective controlled clinical trials. Here, the phytotherapeutics that will be discussed are as follows: quercetin, pollen extracts (Cernilton), and saw palmetto (Serenoa repens). In conclusion, among phytotherapeutics, pollen extracts have the most convincing evidence for use in patients with CP/CPPS. Further studies for quercetin and saw palmetto are warranted as they have already proven to have benefits.
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References
Shoskes DA et al (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54(6):960–963
Rugendorff EW et al (1993) Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 71(4):433–438
Wagenlehner FM et al (2009) A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study. Eur Urol 56(3):544–551
Kaplan SA, Volpe MA, Te AE (2004) A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis/chronic pelvic pain syndrome. J Urol 171(1):284–288
Min K, Ebeler SE (2009) Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. Food Chem Toxicol 47(11):2716–2722
Comalada M et al (2005) In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Eur J Immunol 35(2):584–592
Pandey AK et al (2012) Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection. Int Rev Neurobiol 102:107–146
Harwood M et al (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45(11):2179–2205
Cermak R, Landgraf S, Wolffram S (2003) The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 133(9):2802–2807
Asakawa K et al (2001) Effects of cernitin pollen-extract (Cernilton) on inflammatory cytokines in sex-hormone-induced nonbacterial prostatitis rats. Hinyokika Kiyo 47(7):459–465
Habib FK et al (1990) In vitro evaluation of the pollen extract, cernitin T-60, in the regulation of prostate cell growth. Br J Urol 66(4):393–397
Kimura M et al (1986) Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Planta Med 2:148–151
Talpur N et al (2003) Comparison of Saw Palmetto (extract and whole berry) and Cernitin on prostate growth in rats. Mol Cell Biochem 250(1–2):21–26
Kamijo T, Sato S, Kitamura T (2001) Effect of cernitin pollen-extract on experimental nonbacterial prostatitis in rats. Prostate 49(2):122–131
Cai T, Wagenlehner FM, Luciani LG, Tiscione D, Malossini G, Verze P, Mirone V, Bartoletti R (2014) Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome. Exp Ther Med 8(4):1032–1038
Barry MJ et al (2011) Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. JAMA 306(12):1344–1351
Tacklind J et al (2012) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev (12):CD001423
Acknowledgments
I would like to thank Prof. Truls Erik Bjerklund Johansen who has been a great mentor for me and supported me in this work as in many others. I also appreciate the hard work of Kezban Mirillo who assisted me in gathering the literature.
In conclusion, amongst phytotherapeutics Pollen extracts have the most convincing evidence for use in patients with CP/CPPS. Further studies for Quercetin and Saw palmetto are warranted as they have already proven to have benefits.
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Tandogdu, Z., Cek, M. (2016). The Role of Phytotherapy in the Management of Prostatitis Patients. In: Cai, T., Bjerklund Johansen, T. (eds) Prostatitis and Its Management. Springer, Cham. https://doi.org/10.1007/978-3-319-25175-2_8
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DOI: https://doi.org/10.1007/978-3-319-25175-2_8
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