Abstract
The development of sustainable technologies which are more ecofriendly as common alternatives is a major goal of biotechnology. In this context, microorganisms and their repertoire of biocatalysts serve as a resource in many respects. Styrene-degrading microorganisms and their enzymes also can serve as such a rich resource for biotechnology. The microorganisms, for example, tolerate organic solvents, degrade recalcitrant and toxic compounds, enrich valuable intermediates, and can be genetically manipulated. Thus these can be employed to treat waste streams in order to detoxify polluted air and aquifer. Their regulatory network can also be applied as a form of a biosensor to report on the presence of such toxic compounds. Or the biomass can be used as whole-cell biocatalyst in order to produce valuable compounds such as styrene derivatives for polymer synthesis, indigoid dyes, aroma compounds, or even pharmaceuticals as ibuprofen. The reservoir of biocatalysts can also be used as a source for genetic material. Thus genes can be manipulated and cloned to (recombinantly) produce heterologous enzymes for the biocatalysis in alternative hosts as Escherichia coli. Often these enzymes are later employed to produce (enantiopure) compounds which serve as valuable building blocks for various fields as exemplary aroma production, agrochemistry, food and feed, pharmaceutical production, or polymer chemistry.
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Tischler, D. (2015). Biotechnological Applications of Styrene-Degrading Microorganisms or Involved Enzymes. In: Microbial Styrene Degradation. SpringerBriefs in Microbiology. Springer, Cham. https://doi.org/10.1007/978-3-319-24862-2_5
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