Skip to main content
SpringerLink
Log in

The Rolling Nagoya Mouse

  • Chapter
  • First Online:
Essentials of Cerebellum and Cerebellar Disorders

  • 74k Accesses

Abstract

The natural mutant mouse rolling Nagoya is severely ataxic and frequently shows body roll-overs. A missense mutation was identified in Cacna1a, the gene encoding the α1 pore subunit of CaV2.1 type voltage-gated Ca2+ channels. We here discuss the main phenotypic and neuronal characteristics of this mutant, with relevance to the human neurological disorders associated with CaV2.1 dysfunction (‘Ca2+-channelopathies’).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Bishop GA, Seelandt CM, King JS (2000) Cellular localization of corticotropin releasing factor receptors in the adult mouse cerebellum. Neuroscience 101:1083–1092

    Article  CAS  PubMed  Google Scholar 

  • de Vries B, Frants RR, Ferrari MD et al (2009) Molecular genetics of migraine. Hum Genet 126:115–132

    Article  CAS  PubMed  Google Scholar 

  • Dolphin AC (2009) Calcium channel diversity: multiple roles of calcium channel subunits. Curr Opin Neurobiol 19:237–244

    Article  CAS  PubMed  Google Scholar 

  • Fukumoto N, Obama Y, Kitamura N et al (2009) Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience 160:165–173

    Article  CAS  PubMed  Google Scholar 

  • Fukumoto N, Kitamura N, Niimi K et al (2012) Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neurosci Res 73:199–206

    Article  CAS  PubMed  Google Scholar 

  • Jen JC, Graves TD, Hess EJ et al (2007) Primary episodic ataxias: diagnosis, pathogenesis and treatment. Brain 130:2484–2493

    Article  CAS  PubMed  Google Scholar 

  • Kaja S, van de Ven RC, van Dijk JG et al (2007) Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya. Eur J Neurosci 25:2009–2020

    Article  PubMed  Google Scholar 

  • Kanno T, Suga S, Nakano K et al (1999) Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells. Diabetes 48:1741–1746

    Article  CAS  PubMed  Google Scholar 

  • Kinoshita K, Watanabe Y, Asai H et al (1995) Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area. Br J Pharmacol 116:3274–3278

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maselli RA, Books W, Dunne V (2003) Effect of inherited abnormalities of calcium regulation on human neuromuscular transmission. Ann N Y Acad Sci 998:18–28

    Article  CAS  PubMed  Google Scholar 

  • Matsushita K, Wakamori M, Rhyu IJ et al (2002) Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J Neurosci 22:4388–4398

    CAS  PubMed  Google Scholar 

  • Mori Y, Wakamori M, Oda S et al (2000) Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)). J Neurosci 20:5654–5662

    CAS  PubMed  Google Scholar 

  • Muramoto O, Kanazawa I, Ando K (1981) Neurotransmitter abnormality in Rolling mouse Nagoya, an ataxic mutant mouse. Brain Res 215:295–304

    Article  CAS  PubMed  Google Scholar 

  • Nakamura T, Honda M, Kimura S et al (2005) Taltirelin improves motor ataxia independently of monoamine levels in rolling mouse nagoya, a model of spinocerebellar atrophy. Biol Pharm Bull 28:2244–2247

    Article  CAS  PubMed  Google Scholar 

  • Nielsen EO, Kaja S (2014) GABA receptor expression in the forebrain of ataxic mice. Biol Med (Aligarh) 6:198

    Article  Google Scholar 

  • Oda S (1973) The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance (author’s transl). Jikken Dobutsu 22:281–288

    CAS  PubMed  Google Scholar 

  • Oda S, Lee KJ, Arii T et al (2010) Differential regulation of Purkinje cell dendritic spines in rolling mouse Nagoya (tgrol/tgrol), P/Q type calcium channel (alpha1A/Cav2.1) mutant. Anat Cell Biol 43:211–217

    Article  PubMed  PubMed Central  Google Scholar 

  • Ohba T, Takahashi E, Murakami M (2009) Modified autonomic regulation in mice with a P/Q-type calcium channel mutation. Biochem Biophys Res Commun 381:27–32

    Article  CAS  PubMed  Google Scholar 

  • Onodera H, Takase S, Oda S et al (1988) Neurotransmitter receptors of the rolling mouse Nagoya: a quantitative autoradiographic study. Neurosci Res 5:316–324

    Article  CAS  PubMed  Google Scholar 

  • Rhyu IJ, Oda S, Uhm CS et al (1999) Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Neurosci Lett 266:49–52

    Article  CAS  PubMed  Google Scholar 

  • Sawada K, Sakata-Haga H, Ando M et al (2001) An increased expression of Ca(2+) channel alpha(1A) subunit immunoreactivity in deep cerebellar neurons of rolling mouse Nagoya. Neurosci Lett 316:87–90

    Article  CAS  PubMed  Google Scholar 

  • Sawada K, Hosoi E, Bando M et al (2008) Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya. Neuroscience 152:609–617

    Article  CAS  PubMed  Google Scholar 

  • Takahashi E, Niimi K, Itakura C (2009a) Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204:241–245

    Article  CAS  PubMed  Google Scholar 

  • Takahashi E, Niimi K, Itakura C (2009b) Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res 1279:50–57

    Article  CAS  PubMed  Google Scholar 

  • Takahashi E, Niimi K, Itakura C (2010a) Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci 41:223–229

    Article  CAS  PubMed  Google Scholar 

  • Takahashi E, Niimi K, Itakura C (2010b) Neonatal motor functions in Cacna1a-mutant rolling Nagoya mice. Behav Brain Res 207:273–279

    Article  CAS  PubMed  Google Scholar 

  • Titulaer MJ, Wirtz PW, Kuks JB et al (2008) The Lambert-Eaton myasthenic syndrome 1988–2008: a clinical picture in 97 patients. J Neuroimmunol 201–202:153–158

    Article  PubMed  Google Scholar 

  • Tomoda H, Kato M, Sakata S et al (1992) Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study. J Neurol Sci 112:106–112

    Article  CAS  PubMed  Google Scholar 

  • Van Den Maagdenberg AM, Haan J, Terwindt GM et al (2007) Migraine: gene mutations and functional consequences. Curr Opin Neurol 20:299–305

    Article  PubMed  Google Scholar 

  • Westenbroek RE, Sakurai T, Elliott EM et al (1995) Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels. J Neurosci 15:6403–6418

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Leiden University Medical Centre, Research Building, S5P, P.O.B. 9600, 2300 RC, Leiden, The Netherlands

    Jaap J. Plomp & Arn M. J. M. van den Maagdenberg

  2. Department of Human Genetics, Leiden University Medical Centre, P.O.B. 9600, NL-2300 RC, Leiden, The Netherlands

    Arn M. J. M. van den Maagdenberg & Else A. Tolner

Authors
  1. Jaap J. Plomp
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arn M. J. M. van den Maagdenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Else A. Tolner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jaap J. Plomp .

Editor information

Editors and Affiliations

  1. Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. FNRS, ULB-Erasme, Bruxelles, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Jeremy D. Schmahmann

  6. Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China

    Ying Shen

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Plomp, J.J., van den Maagdenberg, A.M.J.M., Tolner, E.A. (2016). The Rolling Nagoya Mouse. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_60

Download citation

Publish with us

Policies and ethics

Search

Navigation