Abstract
Cerebellar functions are topographically arranged, enabling cerebellar modulation of vestibular, sensorimotor, and cognitive/limbic domains via cerebrocerebellar circuits. The primary sensorimotor cerebellum linked with cerebral sensorimotor areas is in the anterior lobe – lobules II through V, and adjacent parts of lobule VI; the secondary sensorimotor representation is in lobule VIII. Leg and foot are represented in lobules II, III and VIII; hand in lobules IV, V and VIII; and orofacial movements in paravermal lobules V and VI. The cognitive cerebellum in the posterior lobe is interconnected with association and paralimbic cerebral cortices, and includes lobules VI, VIIA at the vermis, Crus I and II in the hemispheres, and lobule VIIB. Executive function and working memory paradigms engage lobules VI and VII, language recruits the right posterolateral cerebellum, and visual-spatial tasks the left. Lobule IX is coupled with the default mode network. The limbic cerebellum in the posterior vermis regulates affective/emotional processing and autonomic functions. Consistent with this topography, the cerebellar motor syndrome follows damage to cerebellar sensorimotor regions; the cerebellar cognitive affective/Schmahmann syndrome from damage to the cognitive-limbic cerebellum; and vestibular symptoms from damage to the vestibulocerebellum. These syndromes may coexist, or occur in isolation following circumscribed lesions.
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Acknowledgements
Supported in part by RO1 MH067980, the National Ataxia Foundation, Ataxia Telangiectasia Children’s Project, and the Birmingham, MINDlink, and Sidney R. Baer Jr Foundations.
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Stoodley, C.J., Schmahmann, J.D. (2016). Functional Topography of the Human Cerebellum. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_51
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DOI: https://doi.org/10.1007/978-3-319-24551-5_51
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