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Aging in COPD and Idiopathic Pulmonary Fibrosis

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Advances in Geroscience

Abstract

Pulmonary function declines during normal aging, whereas pulmonary inflammation increases. The net effect of aging is an increased risk for the development of Chronic Obstructive Pulmonary Disease (COPD) and idiopathic pulmonary fibrosis (IPF) in susceptible individuals. These diseases accelerate the age-related loss in lung function contributing to disability and premature death. Inasmuch as our population is aging, it is important to mechanistically understand the role of aging on the pathobiology of these lung diseases. Lung aging, with its exposure to external factors over many years should be integrated into the complex profiling of COPD and IPF. The understanding of the role played by aging hallmarks in the pathophysiology of COPD and Idiopathic pulmonary fibrosis will be addressed in this chapter. Moreover, future directions and the missing links will be discussed in this chapter.

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Acknowledgments

Dr. Sanchez work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM103629-04 and the American Thoracic Society and Scleroderma Foundation award 552114G1.

Editor: Anthony Punturieri, National Heart, Lung and Blood Institute (NHLBI), NIH.

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  1. Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Medical School, SL-9, 1430 Tulane Avenue, New Orleans, LA, 70112, USA

    Cecilia G. Sanchez Ph.D.

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  1. Cecilia G. Sanchez Ph.D.
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Correspondence to Cecilia G. Sanchez Ph.D. .

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Editors and Affiliations

  1. National Inst. of Aging Division of Aging Biology, National Institutes of Health, Bethesda, Maryland, USA

    Felipe Sierra

  2. National Inst on Aging/ National Inst of Health, Division of Aging Biology, Bethesda, Maryland, USA

    Ronald Kohanski

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Sanchez, C.G. (2016). Aging in COPD and Idiopathic Pulmonary Fibrosis. In: Sierra, F., Kohanski, R. (eds) Advances in Geroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-23246-1_15

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