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EBNA2 and Its Coactivator EBNA-LP

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Epstein Barr Virus Volume 2

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 391))

Abstract

While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.

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Notes

  1. 1.

    In this review, we will refer to the primary structure of EBNA2 using the Swiss-Prot data entry of EBV laboratory strain 95-8:P12978.

Abbreviations

CBF1:

C-promoter binding factor

EBNA:

Epstein-Barr virus nuclear antigen

EBNA-LP:

Epstein-Barr virus leader protein

LMP:

Latent membrane protein

LCL:

Lymphoblastoid cell line

LCV:

Lymphocryptovirus

TAD:

Transactivation domain

PML-NB:

Promyelocytic leukemia nuclear body

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Acknowledgments

The research of BK is supported by the HELENA graduate school of the Helmholtz Center Munich and the Deutsche Krebshilfe (grant 109258). PDL is supported by NIH grant 5R01AI080681.

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Authors and Affiliations

  1. Department of Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistr. 25, 81377, Munich, Germany

    Bettina Kempkes

  2. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA

    Paul D. Ling

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  1. Bettina Kempkes
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  2. Paul D. Ling
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Correspondence to Bettina Kempkes .

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  1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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Kempkes, B., Ling, P.D. (2015). EBNA2 and Its Coactivator EBNA-LP. In: Münz, C. (eds) Epstein Barr Virus Volume 2. Current Topics in Microbiology and Immunology, vol 391. Springer, Cham. https://doi.org/10.1007/978-3-319-22834-1_2

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