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Circadian Rhythms and Cellular Networks in Depression and Associated Disorders

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Cellular Rhythms and Networks

Part of the book series: SpringerBriefs in Cell Biology ((SBCB))

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Abstract

Increasing evidences have indicated that circadian disruptions may be an essential factor in the pathophysiology of anxiety, major depressive disorder (MDD), bipolar disorders, and seasonal affective disorder (SAD). Depression and abnormal circadian rhythms may share a common etiology with lower cellular resilience and resistance to stressful events. On the basis of systems biology, factors at various levels have been associated with the development of depression, including alterations in the circadian pathways, HPA-axis, and human–environment interactions. Variants in the circadian genes have significant roles in the susceptibility and recurrence of mood disorders. The pattern analysis of systemic circadian profiles can be useful for the prediction and prevention of various psychiatric disorders with implications for personalized diagnosis and treatment. Chronotherapy such as scheduled medications indicate that the circadian systems may be a crucial target for the better treatment of depression and associated disorders.

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Authors and Affiliations

  1. PharmTao, Santa Clara, CA, USA

    Qing Yan

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  1. Qing Yan
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Yan, Q. (2015). Circadian Rhythms and Cellular Networks in Depression and Associated Disorders. In: Cellular Rhythms and Networks. SpringerBriefs in Cell Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-22819-8_4

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