Skip to main content

Supplementation: Its Evolving Role in Prevention

  • Chapter
Preventive Nutrition

Abstract

Modern Western thinking expresses reliance on nutritional intervention as well as behavioral modalities such as meditation or acupuncture as “alternative medicine,” with our twentieth-century construct of pharmaceutical and surgical interventions cast as “mainstream medicine.” This nomenclature lacks historical perspective, as traditional, largely plant-based medicine can be found in cultures around the globe, such as the Ayurvedic, Traditional Chinese Medicine, or the European phytochemistry traditions such as are represented today by the German Commission E monographs. Indeed, the modern pharmaceutical industry has heavily relied on natural products for medicinal chemistry leads and sometimes for pharmaceutical actives themselves. All nutrition-based approaches can be considered alternative medicine in the US, as the curriculum of most medical schools is tragically deficient in nutrition education (Am J Clin Nutr 83:941S–4S, 2006).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Adams KM, Lindell KC, Kohlmeier M, Zeisel SH. Status of nutrition education in medical schools. Am J Clin Nutr. 2006;83:941S–4S.

    PubMed  PubMed Central  CAS  Google Scholar 

  2. http://www.snopes.com/quotes/futuredoctor.asp#CvyfJwAGLKTpp7WY.99. Accessed 15 Dec 2014.

  3. Council for Responsible Nutrition. New survey reveals high percentage of U.S. population take dietary supplements—and with high confidence. Washington, DC. 2014.

    Google Scholar 

  4. Dickinson A, Boyon N, Shao A. Physicians and nurses use and recommend dietary supplements: Report of a survey. Nutr J. 2009;8:29.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dickinson A, Bonci L, Boyon N, Franco JC. Dietitians use and recommend dietary supplements: Report of a survey. Nutr J. 2012;11:14.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Frank E, Bendich A, Denniston M. Use of vitamin-mineral supplements by female physicians in the United States. Am J Clin Nutr. 2000;72:969–75.

    PubMed  CAS  Google Scholar 

  7. Grodstein F, O’Brien J, Kang JH, Dushkes R, et al. Long-term multivitamin supplementation and cognitive function in men: a randomized trial. Ann Intern Med. 2013;159:806–14.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the U.S. Preventive services task force. Ann Intern Med. 2013;159:824–34.

    Article  PubMed  Google Scholar 

  9. Guallar E, Stranges S, Mulrow C, Appel LJ, Miller 3rd ER. Enough is enough: stop wasting money on vitamin and mineral supplements. Ann Intern Med. 2013;159:850–1.

    Article  PubMed  Google Scholar 

  10. Bjelakovic G, Nikolova D, Gluud C. Antioxidant supplements to prevent mortality. JAMA. 2013;310:1178–9.

    Article  PubMed  CAS  Google Scholar 

  11. Miller 3rd ER, Pastor-Barriuso R, Dalal D, Riemersma RA, et al. Meta-analysis: high-dosage vitamin e supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37–46.

    Article  PubMed  CAS  Google Scholar 

  12. Skerrett PJ. FDA needs stronger rules to ensure the safety of dietary supplements. www.health.harvard.edu/blog/fda-needs-stronger-rules-to-ensure-the-safety-of-dietary-supplements-201202024182. Accessed 15 Dec 2014.

  13. Sears DS. Don’t be fooled by dietary supplement claims. CNN Opinion. http://www.cnn.com/2014/06/25/opinion/seres-dietary-supplements. Accessed 15 Dec 2014.

  14. Nutraingredients. A global look at supplements on the rise. http://www.nutraingredients.com/Suppliers2/A-global-look-at-supplements-on-the-rise. Accessed 10 Dec 2014.

  15. Soller RW, Bayne HJ, Shasheen C. The regulated dietary supplement industry: myths of an unregulated industry dispelled. HerbalGram. 2012;93:42–57.

    Google Scholar 

  16. NBJ’s supplement business report. Nutr Business J. 2014:11–20.

    Google Scholar 

  17. Nutrition Business Journal. U.S. nutrition industry prospers in 2007, despite economic slump. July 2008.

    Google Scholar 

  18. FDA. Dietary supplements. http://www.fda.gov/Food/DietarySupplements/default.htm. Accessed 10 Dec 2014.

  19. Wallace TC, MacKay D, Al-Mondhiry R, Nguyen H, Griffiths JC. Dietary supplement regulation in the United States. New York: Springer; 2013.

    Book  Google Scholar 

  20. FDA. Significant dates in U.S. Food and Drug Law History. http://www.fda.gov/AboutFDA/WhatWeDo/History/Milestones/ucm128305.htm. Accessed 10 Dec 2014.

  21. FDA. Generally recognized as safe (GRAS). http://www.fda.gov/food/ingredientspackaginglabeling/gras/default.htm. Accessed 15 Dec 2014.

  22. FDA. Guidance for industry: a food labeling guide. www.fda.gov/FoodLabelingGuide. Accessed 15 Dec 2014.

  23. FDA. Code of Federal Regulations Title 21. CFR101.13. Nutrient content claims-general principles. 2014.

    Google Scholar 

  24. FDA. Guidance for industry: a food labeling guide (11. Appendix C: Health Claims). 2014.

    Google Scholar 

  25. FDA. Code of Federal Regulations Title 21. CFR101.70. Specific requirements for health claims—petitions for health claims. 2014.

    Google Scholar 

  26. FDA. Code of Federal Regulations Title 21. CFR101.93. Certain types of statements for dietary supplements. 2014.

    Google Scholar 

  27. Health Canada. Drugs and health products—the approach to natural health products. 2014.

    Google Scholar 

  28. Health Canada. Drugs and health products—pathway for licensing natural health products making modern health claims. 2014.

    Google Scholar 

  29. Yang Y. Scientific substantiation of functional food health claims in China. J Nutr. 2008;138:1199S–205S.

    Article  PubMed  Google Scholar 

  30. Yamada K, Sato-Mito N, Nagata J, Umegaki K. Health claim evidence requirements in Japan. J Nutr. 2008;138:1192S–8S.

    PubMed  CAS  Google Scholar 

  31. Regulation (EC) No 1924/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods. 2006. Official Journal of the European Union. L404/1-25.

    Google Scholar 

  32. Black RE, Allen LH, Bhutta ZA, Caulfield LE, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371:243–60.

    Article  PubMed  Google Scholar 

  33. United Nations—Standing Committee on Nutrition. 6th report on the world nutrition situation: progress in nutrition. 2010.

    Google Scholar 

  34. Bhutta ZA, Chopra M, Axelson H, Berman P, et al. Countdown to 2015 decade report (2000–2010): taking stock of maternal, newborn, and child survival. Lancet. 2010;375:2032–44.

    Article  PubMed  Google Scholar 

  35. Hoddinott J, Rosegrant M, Torero M. Hunger and malnutrition: Investments to reduce hunger and undernutrition. Copenhagen Consensus. 2012;2012:1–68.

    Google Scholar 

  36. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162:2269–76.

    Article  PubMed  Google Scholar 

  37. US Department of Health and Human Services. US Department of Agriculture: “Dietary Guidelines for Americans, 2010.”. 7th ed. Washington, DC: US Government Printing Office; 2011.

    Google Scholar 

  38. Fulgoni 3rd VL, Keast DR, Bailey RL, Dwyer J. Foods, fortificants, and supplements: where do Americans get their nutrients? J Nutr. 2011;141:1847–54.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Burnett-Hartman AN, Fitzpatrick AL, Gao K, Jackson SA, Schreiner PJ. Supplement use contributes to meeting recommended dietary intakes for calcium, magnesium, and vitamin C in four ethnicities of middle-aged and older Americans: the multi-ethnic study of atherosclerosis. J Am Diet Assoc. 2009;109:422–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ. Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc. 2007;107:1322–32.

    Article  PubMed  CAS  Google Scholar 

  41. Agarwal S, Reider C, Brooks JR, Fulgoni 3rd VL. Comparison of prevalence of inadequate nutrient intake based on body weight status of adults in the united states: an analysis of NHANES. J Am Coll Nutr. 2015;2015:1–9.

    CAS  Google Scholar 

  42. Moshfegh AJ, Goldman JD, Cleveland LE. What we eat in America, NHANES 2001–2002: usual nutrient intakes from food compared to dietary reference intakes. U.S. Department of Agriculture, Agriculture Research Service. 2005. p. 1–24.

    Google Scholar 

  43. Crocetti AF, Guthrie HA. Eating behavior and associated nutrient quality of diets. New York: Anarem Systems Research Corporation; 1983.

    Google Scholar 

  44. Ames BN, McCann JC, Stampfer MJ, Willett WC. Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. Am J Clin Nutr. 2007;86:522–3; author reply 523–4.

    PubMed  CAS  Google Scholar 

  45. Heaney RP. Nutrients, endpoints, and the problem of proof. J Nutr. 2008;138:1591–5.

    PubMed  CAS  Google Scholar 

  46. Combs Jr GF, Hassan N, Dellagana N, Staab D, et al. Apparent efficacy of food-based calcium supplementation in preventing rickets in Bangladesh. Biol Trace Elem Res. 2008;121:193–204.

    Article  PubMed  CAS  Google Scholar 

  47. Ames BN. The metabolic tune-up: metabolic harmony and disease prevention. J Nutr. 2003;133:1544S–8S.

    PubMed  CAS  Google Scholar 

  48. Heaney RP, Armas LA. Screening for vitamin d deficiency: is the goal disease prevention or full nutrient repletion? Ann Intern Med. 2015;162:144–5.

    Article  PubMed  Google Scholar 

  49. Bouillon R, Van Schoor NM, Gielen E, Boonen S, et al. Optimal vitamin d status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013;98:E1283–304.

    Article  PubMed  CAS  Google Scholar 

  50. American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for prevention of falls and their consequences. J Am Geriatr Soc. 2014;62:147–52.

    Article  Google Scholar 

  51. Hemila H, Chalker E. Vitamin c for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;1, CD000980.

    PubMed  Google Scholar 

  52. AHA. http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/HealthyDietGoals/Fish-and-Omega-3-Fatty-Acids_UCM_303248_Article.jsp. Accessed 15 Dec 2014.

  53. http://www.st.nmfs.noaa.gov/Assets/commercial/fus/fus13/09_percapita2013.pdf. Accessed 15 Dec 2014.

  54. Weintraub HS. Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad Med. 2014;126:7–18.

    Article  PubMed  Google Scholar 

  55. http://health.gov/dietaryguidelines/dga2005/report/html/d6_selectedfood.htm. Accessed 15 Dec 2014.

  56. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr. 2013;143:818–26.

    Article  PubMed  CAS  Google Scholar 

  57. Richardson G, Hicks SL, O’Byrne S, Frost MT, et al. The ingestion of inorganic nitrate increases gastric s-nitrosothiol levels and inhibits platelet function in humans. Nitric Oxide. 2002;7:24–9.

    Article  PubMed  CAS  Google Scholar 

  58. Hobbs DA, George TW, Lovegrove JA. The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev. 2013;26:210–22.

    Article  PubMed  CAS  Google Scholar 

  59. Joris PJ, Mensink RP. Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal. Atherosclerosis. 2013;231:78–83.

    Article  PubMed  CAS  Google Scholar 

  60. Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, et al. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived no. Hypertension. 2010;56:274–81.

    Article  PubMed  CAS  Google Scholar 

  61. Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A. Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Nitric Oxide. 2012;26:197–202.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  62. Coles LT, Clifton PM. Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutr J. 2012;11:106.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Lupton JR, Atkinson SA, Chang N, Fraga CG, et al. Exploring the benefits and challenges of establishing a DRI-like process for bioactives. Eur J Nutr. 2014;53 Suppl 1:1–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  64. Williamson G, Holst B. Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction? Br J Nutr. 2008;99 Suppl 3:S55–8.

    PubMed  CAS  Google Scholar 

  65. Jackson RD, LaCroix AZ, Gass M, Wallace RB, et al. Calcium plus vitamin d supplementation and the risk of fractures. N Engl J Med. 2006;354:669–83.

    Article  PubMed  CAS  Google Scholar 

  66. Cumming RG. Calcium intake and bone mass: a quantitative review of the evidence. Calcif Tissue Int. 1990;47:194–201.

    Article  PubMed  CAS  Google Scholar 

  67. Gaziano JM, Sesso HD, Christen WG, Bubes V, et al. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2012;308:1871–80.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  68. Bach PB, Lewis RJ. Multiplicities in the assessment of multiple vitamins: is it too soon to tell men that vitamins prevent cancer? JAMA. 2012;308:1916–7.

    Article  PubMed  CAS  Google Scholar 

  69. Blot WJ, Li JY, Taylor PR, Guo W, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993;85:1483–92.

    Article  PubMed  CAS  Google Scholar 

  70. Qiao YL, Dawsey SM, Kamangar F, Fan JH, et al. Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian general population nutrition intervention trial. J Natl Cancer Inst. 2009;101:507–18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  71. Chew EY, Clemons TE, Agron E, Sperduto RD, et al. Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36. JAMA Ophthalmol. 2014;132:272–7.

    Article  PubMed  Google Scholar 

  72. Chew EY, Clemons TE, Agron E, Sperduto RD, et al. Long-term effects of vitamins C and E, beta-carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophthalmology. 2013;120:1604–1611.e4.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the age-related eye disease study 2 (AREDS2) randomized clinical trial. JAMA. 2013;309:2005–15.

    Google Scholar 

  74. Group AR, Chew EY, Clemons T, SanGiovanni JP, et al. The age-related eye disease study 2 (AREDS2): Study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012;119:2282–9.

    Article  Google Scholar 

  75. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol. 2001;119:1439–52.

    Google Scholar 

  76. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417–36.

    Google Scholar 

  77. Age-Related Eye Disease Study 2 Research Group, Chew EY, SanGiovanni JP, Ferris FL, et al. Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. JAMA Ophthalmol. 2013;131:843–50.

    Google Scholar 

  78. Richer S, Stiles W, Ulanski L, Carroll D, Podella C. Observation of human retinal remodeling in octogenarians with a resveratrol based nutritional supplement. Nutrients. 2013;5:1989–2005.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  79. McHugh RT, Hollins JL, Lau FC, Daggy BP. Effect of the combination of AREDS2 formulation and a polyphenol preparation on dry age-related macular degeneration: analysis of case studies. American Society for Nutrition Conference Proceedings, Boston, 2014.

    Google Scholar 

  80. Block G, Jensen CD, Norkus EP, Dalvi TB, et al. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study. Nutr J. 2007;6:30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  81. Harley CB, Chan J, Blauwkamp M, Lau FC, et al. Cross-sectional analysis of telomere length in people 33–80 years of age: effects of dietary supplementation. American College of Nutrition Proceedings, San Antonio. 2014.

    Google Scholar 

  82. Yang B, Fan S, Zhi X, Wang Y, et al. Prevalence of hyperhomocysteinemia in China: a systematic review and meta-analysis. Nutrients. 2014;7:74–90.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  83. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340:1449–54.

    Article  PubMed  CAS  Google Scholar 

  84. Hickling S, Hung J, Knuiman M, Jamrozik K, et al. Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study. J Epidemiol Community Health. 2005;59:371–6.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Berry RJ, Li Z, Erickson JD, Li S, et al. Prevention of neural-tube defects with folic acid in china. China-U.S. collaborative project for neural tube defect prevention. N Engl J Med. 1999;341:1485–90.

    Article  PubMed  CAS  Google Scholar 

  86. Schnyder G, Roffi M, Pin R, Flammer Y, et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med. 2001;345:1593–600.

    Article  PubMed  CAS  Google Scholar 

  87. Quinlivan EP, McPartlin J, McNulty H, Ward M, et al. Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet. 2002;359:227–8.

    Article  PubMed  CAS  Google Scholar 

  88. Kirke PN, Molloy AM, Daly LE, Burke H, et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med. 1993;86:703–8.

    PubMed  CAS  Google Scholar 

  89. Mills JL, McPartlin JM, Kirke PN, Lee YJ, et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet. 1995;345:149–51.

    Article  PubMed  CAS  Google Scholar 

  90. Hao L, Ma J, Zhu J, Stampfer MJ, et al. Vitamin B-12 deficiency is prevalent in 35- to 64-year-old Chinese adults. J Nutr. 2007;137:1278–85.

    PubMed  CAS  Google Scholar 

  91. Euromonitor. Vitamins and dietary supplements in China. 2014.

    Google Scholar 

  92. Ulloa J, Sambrotta L, Redko F, Mazza ON, et al. Detection of a tadalafil analogue as an adulterant in a dietary supplement for erectile dysfunction. J Sex Med. 2014;12:152–7.

    Article  PubMed  CAS  Google Scholar 

  93. Institute of Medicine. Dietary Reference Intakes: the essential guide to nutrient requirements. Washington, DC: National Academies Press, 2006.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bruce P. Daggy Ph.D., F.A.C.N. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Daggy, B.P., Lau, F.C. (2015). Supplementation: Its Evolving Role in Prevention. In: Bendich, A., Deckelbaum, R. (eds) Preventive Nutrition. Nutrition and Health. Springer, Cham. https://doi.org/10.1007/978-3-319-22431-2_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-22431-2_39

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22430-5

  • Online ISBN: 978-3-319-22431-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics