Abstract
Hand, foot and mouth disease (HFMD), caused by highly infectious intestinal viruses of either coxsackievirus A16 (CVA16) or enterovirus 71 (EV71), is a common children syndrome featured by mild fever, spots and bumps that blister the skin of hands, oral cavity in mouth, feet and sometimes to the extent of buttocks and genitalia. Though CVA16 and EV71 both cause the HFMD, the intensity of each symptom is obviously different. Normal cases are HFMD by CVA16, which are typically characterized by mild symptoms usually treated in 6−8 days. Conversely, HFMD by EV71 results severe neural disorders and various influenza complications that even cause death. Currently, no vaccine is available to protect individuals from infection by the viruses that cause HFMD. In order to investigate why these two viruses have too much differences in degree of symptoms and compare the inner relationships to the medical effects, we analyzed the genomes of CVA16 and EV71 by using apriori algorithm, decision tree and support vector machine (SVM). Therefore, by comparing the genomes of each virus, we found out better results for analyzing the relationship between the two and state the potential of developing medical remedy in DNA point of view.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Chen, X.P., Tan, X.J., Xu, W.B.: Research Advances in Molecular Epidemiology and Vaccines of Coxsackievirus A16. US National Library of Medicine National Institutes of Health. Bing Du Xue Bao, 30 July 2014
Hou, W., Yang, L., He, D., Zheng, J., Xu, L., Liu, J., Zhao, H., Liu, Y., Ye, X., Cheng, T., Xia, N.: Development of a Coxsackievirus A16 Neutralization Test Based on the Enzyme-linked Immunospot Assay. National Center for Biotechnology Information. U.S. National Library of Medicine
Lu, G., Qi, J., Chen, Z., Xu, X., Gao, F., Lin, D., Qian, W., Liu, H., Jiang, H., Yan, J., Gao, G.F.: Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. Journal of Virology 85, 10319–10331 (2011). American Society for Microbiology
Pourianfar, H.R., Kirk, K., Grollo, L.: Initial Evidence on Differences among Enterovirus 71, Coxsackievirus A16 and Coxsackievirus B4 in Binding to Cell Surface Heparan Sulphate. National Center for Biotechnology Information. U.S. National Library of Medicine, 4 December 2013
Zhao, H., Li, H.Y., Han, J.F., Deng, Y.Q., Zhu, S.Y., Li, X.F., Yang, H.Q., Li, Y.X., Zhang, Y., Qin, E.D., Chen, R., Qin, C.F.: Novel recombinant Chimeric Virus-like particle is immunogenic and protective against both Enterovirus 71 and Coxsackievirus A16 in Mice. National Center for Biotechnology Information, U.S. National Library of Medicine
Zhu, Z., Zhu, S., Guo, X., Wang, J., Wang, D., Yan, D., Tan, X., Tang, L., Zhu, H., Yang, Z., Jiang, X., Ji, Y., Zhang, Y., Xu, W.: Retrospective seroepidemiology indicated that human Enterovirus 71 and Coxsackievirus A16 circulated wildly in central and Southern China before large-scale outbreaks from 2008. J. Virol. 7(1), 300 (2010)
Go, E., Lee, S., Yoon, T.: Analysis of Ebolavirus with decision tree and apriori algorithm. Int. J. Mach. Learn. Comput. 4(6), 543–546 (2014)
Theodoridis, S., Koutroumbas, K.: Pattern Recognition, 4th edn. Academic Press, Burlington (2009). ISBN 978-1-59749-272-0
Shih, S.R., Stollar, V., Lin, J.Y., Chang, S.C., Chen, G.W., Li, M.L.: Identification of genes involved in the host response to enterovirus 71 infection. J. Neurovirol. 10(5), 293–304 (2004). doi:10.1080/13550280490499551. PMID 15385252
Shimizu, H., Utama, A., Yoshii, K., et al.: Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997–1998. Jpn. J. Infect. Dis. 52(1), 12–5 (1999). PMID 10808253
Agrawal, R., Srikant, R.: Fast algorithms for mining association rules, pp. 1–32. IBM Almaden Research Center
Enterovirus 71 Infection. Centre for Health Protection
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Jung, C., Park, Y., Han, S., Yoon, T. (2015). Analyzing the Genomes of Coxsackievirus A16 and Enterovirus 71 in Relation to Hand, Foot and Mouth Disease(HFMD) Using Apriori Algorithm, Decision Tree and Support Vector Machine (SVM). In: Huang, DS., Bevilacqua, V., Premaratne, P. (eds) Intelligent Computing Theories and Methodologies. ICIC 2015. Lecture Notes in Computer Science(), vol 9225. Springer, Cham. https://doi.org/10.1007/978-3-319-22180-9_53
Download citation
DOI: https://doi.org/10.1007/978-3-319-22180-9_53
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-22179-3
Online ISBN: 978-3-319-22180-9
eBook Packages: Computer ScienceComputer Science (R0)