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The Role of Antiepileptic Drugs

  • Chapter
Neuropsychiatric Symptoms of Epilepsy

Part of the book series: Neuropsychiatric Symptoms of Neurological Disease ((NSND))

Abstract

Antiepileptic drugs (AEDs) suppress seizures by acting on a variety of mechanisms and molecular targets involved in the regulation of neuronal excitability. These include inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmission, as well as ion (sodium and calcium) conductance through voltage-gated channels. However, these mechanisms and targets are also implicated in the regulation of mood and behavior, which may explain why each AED is associated with specific psychotropic effects. This chapter will discuss the role of mechanisms and molecular targets of AEDs in mood and behavior, and review the positive and negative psychotropic effects of AEDs.

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Abbreviations

AED:

Antiepileptic drug

CBZ:

Carbamazepine

EMA:

European Medicines Agency

ESL:

Eslicarbazepine

ETX:

Ethosuximide

FDA:

Food and Drug Administration

FLB:

Felbamate

GBP:

Gabapentin

HRSA:

Hamilton Rating Scale for Anxiety

LAC:

Lacosamide

LEV:

Levetiracetam

LTG:

Lamotrigine

OXC:

Oxcarbazepine

PGB:

Pregabalin

PHT:

Phenytoin

RTG:

Retigabine

RUF:

Rufinamide

STP:

Stiripentol

TGB:

Tiagabine

TPM:

Topiramate

VGB:

Vigabatrin

VPA:

Valproate

ZNS:

Zonisamide

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Authors and Affiliations

  1. Epilepsy Group, Atkinson Morley Regional Neuroscience Centre, St. George’s University Hospitals NHS Foundation Trust, Blackshaw Road, London, SW17 0QT, UK

    Mahinda Yogarajah BSc, MBBS, MRCP, PhD & Marco Mula MD, PhD

  2. Institute of Medical and Biomedical Sciences, St George’s University of London, London, UK

    Marco Mula MD, PhD

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  1. Atkinson Morley Regional Neuroscience Centre, Epilepsy Group, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    Marco Mula

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Yogarajah, M., Mula, M. (2016). The Role of Antiepileptic Drugs. In: Mula, M. (eds) Neuropsychiatric Symptoms of Epilepsy. Neuropsychiatric Symptoms of Neurological Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-22159-5_18

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