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Three-Dimensional Bioprinting in Regenerative Medicine

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Book cover Bioprinting in Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

With the advances of stem cell research, development of intelligent biomaterials and three-dimensional biofabrication strategies, highly mimicked tissue or organs can be engineered. Among all the biofabrication approaches, bioprinting based on inkjet printing technology has the promises to deliver and create biomimicked tissue with high throughput, digital control, and the capacity of single cell manipulation. Therefore, this enabling technology has great potential in regenerative medicine and translational applications. The most current advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this chapter, including vasculature , muscle , cartilage , and bone . In addition, the benign side effect of bioprinting to the printed mammalian cells can be utilized for gene or drug delivery, which can be achieved conveniently during precise cell placement for tissue construction. With layer-by-layer assembly, three-dimensional tissues with complex structures can be printed using converted medical images. Therefore, bioprinting based on thermal inkjet is so far the most optimal solution to engineer vascular system to the thick and complex tissues. Collectively, bioprinting has great potential and broad applications in tissue engineering and regenerative medicine. The future advances of bioprinting include the integration of different printing mechanisms to engineer biphasic or triphasic tissues with optimized scaffolds and further understanding of stem cell biology.

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Acknowledgements

The author would like to acknowledge Guohao Dai, Arndt F. Schilling, M.G. Finn, Kurt Breitenkamp for constructive suggestions and technical support. This work was funded by the Fundamental Research Funds for the Central Universities (WUT: 2015IB004), NSF 1011796, New York Capital Region Research Alliance grant, and Stemorgan Therapeutics R&D support (TERM002). The authors indicate no potential conflict of interest.

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Authors and Affiliations

  1. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 122 Luoshi Road, Wuhan, Hubei, China

    Xiaofeng Cui Ph.D.

  2. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 Eighth St, 12180, Troy, NY, USA

    Xiaofeng Cui Ph.D.

  3. Stemorgan Therapeutics, 12207, Albany, NY, USA

    Xiaofeng Cui Ph.D.

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  1. Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Canada

    Kursad Turksen

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Cui, X. (2015). Three-Dimensional Bioprinting in Regenerative Medicine. In: Turksen, K. (eds) Bioprinting in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21386-6_5

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