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The Role of the Microbiome in the Relationship of Asthma and Affective Disorders

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Part of the book series: Advances in Experimental Medicine and Biology ((MICENDO,volume 874))

Abstract

The effect of stress, anxiety and other affective states on inflammatory conditions such as asthma is well documented. Although several immune pathway mechanisms have been proposed and studied, they cannot fully explain the relationship. In this chapter we present a new perspective on asthma development and exacerbation that integrates findings on the role of psychological factors in asthma with the microbiome and the hygiene hypothesis in asthma development.

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References

  • Al-Asmakh M, Anuar F, Zadjali F, Rafter J, Pettersson S (2012) Gut microbial communities modulating brain development and function. Gut Microbes 3(4):366

    Article  PubMed Central  PubMed  Google Scholar 

  • Alcock J, Maley CC, Aktipis CA (2014) Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays 36:940–949. doi:10.1002/bies.201400071

    Article  PubMed Central  PubMed  Google Scholar 

  • Amaral FA, Sachs D, Costa VV, Fagundes CT, Cisalpino D, Cunha TM et al (2008) Commensal microbiota is fundamental for the development of inflammatory pain. Proc Natl Acad Sci U S A 105(6):2193–2197

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Arbes SJ Jr, Gergen PJ, Vaughn B, Zeldin DC (2007) Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 120(5):1139–1145

    Article  PubMed Central  PubMed  Google Scholar 

  • Azad MB, Konya T, Koster B, Maughan H, Guttman DS, Field CJ et al (2012) Infant gut microbiota and the hygiene hypothesis of allergic disease. Allergy Asthma Clin Immunol 8(Suppl 1):A12

    Article  PubMed Central  Google Scholar 

  • Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB et al (2013) Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ 347:f6471

    Article  PubMed Central  PubMed  Google Scholar 

  • Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307(5717):1915–1920

    Article  PubMed  CAS  Google Scholar 

  • Bailey MT, Coe CL (1999) Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol 35:146–155

    Article  CAS  PubMed  Google Scholar 

  • Bailey MT, Dowd SE, Parry NMA, Galley JD, Schauer DB, Lyte M (2010) Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium. Infect Immun 78:1509–1519

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M (2011) Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 25(3):397–407

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA et al (2011) Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 9(12):1044–1049

    Article  PubMed Central  PubMed  Google Scholar 

  • Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL (2000) Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 343:538–543

    Article  CAS  PubMed  Google Scholar 

  • Ball TM, Anderson D, Minto J, Halonen M (2006) Cortisol circadian rhythms and stress responses in infants at risk of allergic disease. J Allergy Clin Immunol 117(2):306–311

    Article  PubMed  Google Scholar 

  • Bansal T, Englert D, Lee J, Hegde M, Wood TK, Jayaraman A (2007) Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157: H7 chemotaxis, colonization, and gene expression. Infect Immun 75(9):4597–4607

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Belay T, Sonnenfeld G (2002) Differential effects of catecholamines on in vitro growth of pathogenic bacteria. Life Sci 71(4):447–456

    Article  CAS  PubMed  Google Scholar 

  • Belay T, Aviles H, Vance M, Fountain K, Sonnenfeld G (2003) Catecholamines and in vitro growth of pathogenic bacteria: enhancement of growth varies greatly among bacterial species. Life Sci 73:1527–1535

    Article  CAS  PubMed  Google Scholar 

  • Bendiks M, Kopp MV (2013) The relationship between advances in understanding the microbiome and the maturing hygiene hypothesis. Curr Allergy Asthma Rep 13(5):487–494

    Article  PubMed  Google Scholar 

  • Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J et al (2011) The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141(2):599–609

    Article  CAS  PubMed  Google Scholar 

  • Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bønnelykke K et al (2007) Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357(15):1487–1495

    Article  CAS  PubMed  Google Scholar 

  • Björkstén B (2004) Effects of intestinal microflora and the environment on the development of asthma and allergy. Springer Semin Immunopathol 3:257–270

    Article  Google Scholar 

  • Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M (2001) Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 108(4):516–520

    Article  PubMed  Google Scholar 

  • Bohórquez DV, Samsa LA, Roholt A, Medicetty S, Chandra R, Liddle RA (2014) An enteroendocrine cell—enteric glia connection revealed by 3D electron microscopy. PLoS One 9(2):e89881

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Bosch JA, Ring C, de Geus EJ, Veerman EC, Nieuw Amerongen AV (2002) Stress and secretory immunity. Int Rev Neurobiol 52:213–253

    Article  CAS  PubMed  Google Scholar 

  • Bosch JA, de Geus EJ, Veerman EC, Hoogstraten J, Amerongen AVN (2003) Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity. Psychosom Med 65(2):245–258

    Article  PubMed  Google Scholar 

  • Bousquet J, Bousquet PJ, Godard P, Daures JP (2005) The public health implications of asthma. Bull World Health Organ 83(7):548–554

    PubMed Central  PubMed  Google Scholar 

  • Boyle RJ, Tang MLK (2006) The role of probiotics in the management of allergic disease. Clin Exp Allergy 36:568–576

    Article  CAS  PubMed  Google Scholar 

  • Brandtzaeg PER (2007) Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann N Y Acad Sci 1098(1):288–311

    Article  CAS  PubMed  Google Scholar 

  • Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG et al (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 108(38):16050–16055

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Buske‐Kirschbaum A, Hellhammer DH (2003) Endocrine and immune responses to stress in chronic inflammatory skin disorders. Ann N Y Acad Sci 992(1):231–240

    Article  PubMed  Google Scholar 

  • Buske-Kirschbaum A, Jobst S, Wustmans A, Kirschbaum C, Rauh W, Hellhammer D (1997) Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis. Psychosom Med 59(4):419–426

    Article  CAS  PubMed  Google Scholar 

  • Buske-Kirschbaum A, Geiben A, Höllig H, Morschhäuser E, Hellhammer D (2002) Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis. J Clin Endocrinol Metab 87(9):4245–4251

    Article  CAS  PubMed  Google Scholar 

  • Buske-Kirschbaum A, von Auer K, Krieger S, Weis S, Rauh W, Hellhammer D (2003) Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease? Psychosom Med 65(5):806–810

    Article  CAS  PubMed  Google Scholar 

  • Chen E, Strunk RC, Bacharier LB, Chan M, Miller GE (2010) Socioeconomic status associated with exhaled nitric oxide responses to acute stress in children with asthma. Brain Behav Immun 4:444–450

    Article  CAS  Google Scholar 

  • Collins SM, Surette M, Bercik P (2012) The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol 10(11):735–742

    Article  CAS  PubMed  Google Scholar 

  • Cookson W (2004) The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol 4(12):978–988

    Article  CAS  PubMed  Google Scholar 

  • Cookson H, Granell R, Joinson C, Ben-Shlomo YA, Henderson J (2009) Mothers’ anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol 123:847–853

    Article  PubMed Central  PubMed  Google Scholar 

  • Daley D (2014) The evolution of the hygiene hypothesis: the role of early-life exposures to viruses and microbes and their relationship to asthma and allergic diseases. Curr Opin Allergy Clin Immunol 14(5):390–396

    Article  CAS  PubMed  Google Scholar 

  • Damman CJ, Miller SI, Surawicz CM, Zisman TL (2012) The microbiome and inflammatory bowel disease: is there a therapeutic role for fecal microbiota transplantation[quest]. Am J Gastroenterol 107(10):1452–1459

    Article  PubMed  Google Scholar 

  • Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Diard S, Lievin-Le Moal V, Toribio AL, Boum Y, Vigier F, Servin AL, Bouvet O (2009) Norepinephrine-dependently released Dr fimbriae of diffusely adhering Escherichia coli strain IH11128 promotes a mitogen-activated protein kinase ERK1/2-dependent production of pro-inflammatory cytokine, IL-8 in human intestinal Caco-2/TC7 cells. Microbes Infect 11:886–894

    Article  CAS  PubMed  Google Scholar 

  • Dickson RP, Erb-Downward JR, Huffnagle GB (2014) Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. Lancet Respir Med 2(3):238–246

    Article  PubMed Central  PubMed  Google Scholar 

  • Douglas-Escobar M, Elliott E, Neu J (2013) Effect of intestinal microbial ecology on the developing brain. JAMA Pediatr 167(4):374–379

    Article  PubMed  Google Scholar 

  • Droste JHJ, Wieringa MH, Weyler JJ, Nelen VJ, Vermeire PA, Van Bever HP (2000) Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy 30:1548–1553

    Article  Google Scholar 

  • Drummond PD, Hewson-Bower B (1997) Increased psychosocial stress and decreased mucosal immunity in children with recurrent upper respiratory tract infections. J Psychosom Res 43:271–278

    Article  CAS  PubMed  Google Scholar 

  • Elazab N, Mendy A, Gasana J, Vieira ER, Quizon A, Forno E (2013) Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics 132(3):e666–e676

    Article  PubMed  Google Scholar 

  • Elenkov IJ, Chrousos GP (1999) Stress hormones, Th1/Th2 patterns, pro/anti-Inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 10(9):359–368

    Article  CAS  PubMed  Google Scholar 

  • Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES (2000) The sympathetic nerve—an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52(4):595–638

    CAS  PubMed  Google Scholar 

  • Feleszko WW, Jaworska JJ, Rha RD, Steinhausen SS, Avagyan AA, Jaudszus AA, Hamelmann EE (2007) Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy 37(4):498–505

    Article  CAS  PubMed  Google Scholar 

  • Forsythe P, Kunze WA (2013) Voices from within: gut microbes and the CNS. Cell Mol Life Sci 70(1):55–69

    Article  CAS  PubMed  Google Scholar 

  • Forsythe P, Inman MD, Bienenstock J (2007) Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. Am J Respir Crit Care Med 175(6):561–569

    Article  PubMed  Google Scholar 

  • Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J (2010) Mood and gut feelings. Brain Behav Immun 24(1):9–16

    Article  PubMed  Google Scholar 

  • Freestone PP, Haigh RD, Lyte M (2007a) Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157: H7, Salmonella enterica and Yersinia enterocolitica. BMC Microbiol 7(1):8

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Freestone PP, Haigh RD, Lyte M (2007b) Specificity of catecholamine-induced growth in Escherichia coli O157:H7. Salmonella enterica and Yersinia enterocolitica. FEMS Microbiol Lett 269:221–228

    Article  CAS  PubMed  Google Scholar 

  • Freestone PP, Hirst RA, Sandrini SM, Sharaff F, Fry H, Hyman S, O’Callaghan C (2012) Pseudomonas aeruginosa-catecholamine inotrope interactions: a contributory factor in the development of ventilator-associated pneumonia? Chest 142(5):1200–1210

    Article  PubMed  Google Scholar 

  • Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ et al (2010) Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60(3):307–317

    Article  PubMed  Google Scholar 

  • Gaykema RP, Goehler LE, Lyte M (2004) Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry. Brain Behav Immun 18:238–245

    Article  CAS  PubMed  Google Scholar 

  • Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5:243–251

    Article  CAS  PubMed  Google Scholar 

  • Glover V (2011) Annual research review: prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry 52(4):356–367

    Article  PubMed  Google Scholar 

  • Glover V, O’Connor TG, O’Donnell K (2010) Prenatal stress and the programming of the HPA axis. Neurosci Biobehav Rev 35(1):17–22

    Article  CAS  PubMed  Google Scholar 

  • Goehler LE, Gaykema R, Opitz N, Reddaway R, Badr N, Lyte M (2005) Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun 19(4):334–344

    Article  PubMed  Google Scholar 

  • Goehler LE, Lyte M, Gaykema R (2007) Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology. Brain Behav Immun 21(6):721–726

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Gogarten JP, Doolittle WF, Lawrence JG (2002) Prokaryotic evolution in light of gene transfer. Mol Biol Evol 19(12):2226–2238

    Article  CAS  PubMed  Google Scholar 

  • Gonzales XF, Castillo-Rojas G, Castillo-Rodal AI, Tuomanen E, López-Vidal Y (2013) Catecholamine norepinephrine diminishes lung epithelial cell adhesion of Streptococcus pneumoniae by binding iron. Microbiology 159(Pt 11):2333–2341

    Article  CAS  PubMed  Google Scholar 

  • Goodwin RD, Fergusson DM, Horwood L (2004) Asthma and depressive and anxiety disorders among young persons in the community. Psychol Med 34(08):1465–1474

    Article  PubMed  Google Scholar 

  • Green BT, Lyte M, Kulkarni-Narla A, Brown DR (2003) Neuromodulation of enteropathogen internalization in Peyer’s patches from porcine jejunum. J Neuroimmunol 141:74–82

    Article  CAS  PubMed  Google Scholar 

  • Greer JB, O’Keefe SJ (2010) Microbial induction of immunity, inflammation, and cancer. Front Physiol 1:1–8

    Article  Google Scholar 

  • Hanage WP (2014) Microbiome science needs a healthy dose of scepticism. Nature 512(7514):247–248

    Article  CAS  PubMed  Google Scholar 

  • Hasler G, Gergen PJ, Kleinbaum DG, Ajdacic V, Gamma A, Eich D et al (2005) Asthma and panic in young adults: a 20-year prospective community study. Am J Respir Crit Care Med 171(11):1224–1230

    Article  PubMed Central  PubMed  Google Scholar 

  • Heijtz DR, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A 108:3047–3052

    Article  PubMed Central  CAS  Google Scholar 

  • Henningsen GM, Hurrel JJ, Baker F, Douglas C, MacKenzie BA, Robertson SK, Phipps FC (1992) Measurement of salivary immunoglobulin A as an immunologic biomarker of job stress. Scand J Work Environ Health 18:133–136

    Article  CAS  PubMed  Google Scholar 

  • Heuser I, Yassouridis A, Holsboer F (1994) The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 28(4):341–356

    Article  CAS  PubMed  Google Scholar 

  • Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C et al (2010) Disordered microbial communities in asthmatic airways. PLoS One 5(1):e8578

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Hoffmann C, Hill DA, Minkah N, Kirn T, Troy A, Artis D, Bushman F (2009) Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infect Immun 77(10):4668–4678

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Holgate ST (2002) Airway inflammation and remodeling in asthma: current concepts. Mol Biotechnol 22(2):179–189

    Article  CAS  PubMed  Google Scholar 

  • Holgate ST (2007) Epithelium dysfunction in asthma. J Allergy Clin Immunol 120:1233–1244

    Article  CAS  PubMed  Google Scholar 

  • Hooper LV, Gordon JI (2001) Commensal host-bacterial relationships in the gut. Science 292(5519):1115–1118

    Article  CAS  PubMed  Google Scholar 

  • Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T et al (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155(7):1451–1463

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Huang YJ, Nelson CE, Brodie EL, DeSantis TZ, Baek MS, Liu J et al (2011) Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 127(2):372–381

    Article  PubMed Central  PubMed  Google Scholar 

  • Hughes DT, Sperandio V (2008) Inter-kingdom signalling: communication between bacteria and their hosts. Nat Rev Microbiol 6(2):111–120

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Iyer LM, Aravind L, Coon SL, Klein DC, Koonin EV (2004) Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends Genet 20(7):292–299

    Article  CAS  PubMed  Google Scholar 

  • Kalueff AV, Nutt DJ (2007) Role of GABA in anxiety and depression. Depress Anxiety 24(7):495–517

    Article  CAS  PubMed  Google Scholar 

  • Kang DH, Coe CL, McCarthy DO, Ershler WB (1997) Immune responses to final exams in healthy and asthmatic adolescents. Nurs Res 46(1):12–19

    Article  CAS  PubMed  Google Scholar 

  • Kilian M, Husby S, Høst A, Halken S (1995) Increased proportions of bacteria capable of cleaving IgA1 in the pharynx of infants with atopic disease. Pediatr Res 38:182–186

    Article  CAS  PubMed  Google Scholar 

  • Kirjavainen PV, Apostolou E, Arvola T, Salminen SJ, Gibson GR, Isolauri E (2001) Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease. FEMS Immunol Med Microbiol 32(1):1–7

    Article  CAS  PubMed  Google Scholar 

  • Knowles SR, Nelson EA, Palombo EA (2008) Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness. Biol Psychol 77(2):132–137

    Article  PubMed  Google Scholar 

  • Korppi M (2010) Bacterial infections and pediatric asthma. Immunol Allergy Clin North Am 30:565–574

    Article  PubMed  Google Scholar 

  • Kozyrskyj AL, Mai XM, McGrath P, HayGlass KT, Becker AB, MacNeil B (2008) Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma. Am J Respir Crit Care Med 177(2):142–147

    Article  PubMed  Google Scholar 

  • Kuklinska D, Kilian M (1984) Relative proportions of Haemophilus species in the throat of healthy children and adults. Eur J Clin Microbiol Infect Dis 3:249–252

    CAS  Google Scholar 

  • Lambrecht BN, Hammad H (2003) Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat Rev Immunol 3(12):994–1003

    Article  CAS  PubMed  Google Scholar 

  • Lavoie KL, Boudreau M, Plourde A, Campbell TS, Bacon SL (2011) Association between generalized anxiety disorder and asthma morbidity. Psychosom Med 73(6):504–513

    Article  PubMed  Google Scholar 

  • Lechin F, Van der Dijs B, Lechin AE (2002) Severe asthma and plasma serotonin. Allergy 57(3):258–259

    Article  CAS  PubMed  Google Scholar 

  • Lee YK, Mazmanian SK (2010) Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330(6012):1768–1773

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lee SC, San Tang M, Lim YA, Choy SH, Kurtz ZD, Cox LM et al (2014) Helminth colonization is associated with increased diversity of the gut microbiota. PLoS Negl Trop Dis 8(5):e2880

    Article  PubMed Central  PubMed  Google Scholar 

  • Leonardi-Bee J, Pritchard D, Britton J (2006) Asthma and current intestinal parasite infection: systematic review and meta-analysis. Am J Respir Crit Care Med 174(5):514–523

    Article  PubMed  Google Scholar 

  • Lin YC, Wen HJ, Lee YL, Guo YL (2004) Are maternal psychosocial factors associated with cord immunoglobulin E in addition to family atopic history and mother immunoglobulin E? Clin Exp Allergy 34:548–554

    Article  PubMed  Google Scholar 

  • Liu LY, Coe CL, Swenson CA, Kelly EA, Kita H, Busse WW (2002) School examinations enhance airway inflammation to antigen challenge. Am J Respir Crit Care Med 165:1062–1067

    Article  PubMed  Google Scholar 

  • Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A et al (2011) Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 127(2):355–360

    Article  PubMed  Google Scholar 

  • Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M et al (2014) Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol 134(3):593–601.e12

    Google Scholar 

  • Lyte M, Arulanandam BP, Frank CD (1996) Production of Shiga-like toxins by Escherichia coli O157:H7 can be influenced by the neuroendocrine hormone norepinephrine. J Lab Clin Med 128:392–398

    Article  CAS  PubMed  Google Scholar 

  • Lyte M, Li W, Opitz N, Gaykema R, Goehler LE (2006) Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol Behav 89(3):350–357

    Article  CAS  PubMed  Google Scholar 

  • Lyte M, Vulchanova L, Brown DR (2011) Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions. Cell Tissue Res 343(1):23–32

    Article  CAS  PubMed  Google Scholar 

  • Macpherson AJ, Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4(6):478–485

    Article  CAS  PubMed  Google Scholar 

  • Maes M (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 19(1):11–38

    Article  CAS  PubMed  Google Scholar 

  • Marks LR, Davidson BA, Knight PR, Hakansson AP (2013) Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease. MBio 4(4):e00438–e004313

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Martinowich K, Manji H, Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10(9):1089–1093

    Article  CAS  PubMed  Google Scholar 

  • Masoli M, Fabian D, Holt S, Beasley R (2004) The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 59:469–478

    Article  PubMed  Google Scholar 

  • Matangkasombut P, Pichavant M, Dekruyff RH, Umetsu DT (2009) Natural killer T cells and the regulation of asthma. Mucosal Immunol 2(5):383–392

    Article  CAS  PubMed  Google Scholar 

  • McNulty NP, Yatsunenko T, Hsiao A, Faith JJ, Muegge BD, Goodman AL et al (2011) The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med 3(106):106ra106

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A et al (2011) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105(05):755–764

    Article  CAS  PubMed  Google Scholar 

  • Morrow LE, Kollef MH, Casale TB (2010) Probiotic prophylaxis of ventilator-associated pneumonia a blinded, randomized, controlled trial. Am J Respir Crit Care Med 182:1058–1064

    Article  PubMed Central  PubMed  Google Scholar 

  • Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7(1):145–173

    Article  CAS  PubMed  Google Scholar 

  • Murk W, Risnes KR, Bracken MB (2011) Prenatal or early-life exposure to antibiotics and risk of childhood asthma: a systematic review. Pediatrics 127:1125–1138

    Article  PubMed  Google Scholar 

  • National Heart, Lung, and Blood Institute/National Asthma Education and Prevention Program (2007) Expert panel report: Guidelines for the diagnosis and management of asthma (NIH Publication No. 07–4051). National Institutes of Health, Bethesda

    Google Scholar 

  • Neufeld KM, Kang N, Bienenstock J, Foster JA (2011) Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 23:255–264

    Article  CAS  PubMed  Google Scholar 

  • Nocker A, Burr M, Camper AK (2007) Genotypic microbial community profiling: a critical technical review. Microb Ecol 54(2):276–289

    Article  CAS  PubMed  Google Scholar 

  • Nockher WA, Renz H (2006) Neurotrophins and asthma: novel insight into neuroimmune interaction. J Allergy Clin Immunol 117(1):67–71

    Article  CAS  PubMed  Google Scholar 

  • Noverr MC, Huffnagle GB (2004) Does the microbiota regulate immune responses outside the gut? Trends Microbiol 12(12):562–568

    Article  CAS  PubMed  Google Scholar 

  • Ogilvie AD, Battersby S, Fink G, Harmar AJ, Goodwin GM, Bubb VJ, Dale Smith CA (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347(9003):731–733

    Article  CAS  PubMed  Google Scholar 

  • Opolski M, Wilson I (2005) Asthma and depression: a pragmatic review of the literature and recommendations for future research. Clin Pract Epidemiol Ment Health 1(1):18

    Article  PubMed Central  PubMed  Google Scholar 

  • Ortega AN, Huertas SE, Canino G, Ramirez R, Rubio-Stipec M (2002) Childhood asthma, chronic illness, and psychiatric disorders. J Nerv Ment Dis 190(5):275–281

    Article  PubMed  Google Scholar 

  • Osborn DA, Sinn JK (2007) Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 4, CD006475

    Google Scholar 

  • Ouwehand AC, Isolauri E, He F, Hashimoto H, Benno Y, Salminen S (2001) Differences in Bifidobacterium flora composition in allergic and healthy infants. J Allergy Clin Immunol 108(1):144–145

    Article  CAS  PubMed  Google Scholar 

  • Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31(9):464–468

    Article  CAS  PubMed  Google Scholar 

  • Penders J, Stobberingh EE, Brandt PA, Thijs C (2007) The role of the intestinal microbiota in the development of atopic disorders. Allergy 62:1223–1236

    Article  CAS  PubMed  Google Scholar 

  • Priftis KN, Papadimitriou A, Anthracopoulos MB, Gatsopoulou E, Fretzayas A, Nicolaidou P, Chrousos G (2006) Adrenal function improves in asthmatic children on inhaled steroids: a longitudinal study. Neuroimmunomodulation 13:56–62

    Article  CAS  PubMed  Google Scholar 

  • Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP (2008) The hypothalamic–pituitary–adrenal axis in asthmatic children. Trends Endocrinol Metab 19(1):32–38

    Article  CAS  PubMed  Google Scholar 

  • Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27:24–33

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM, Logan AC (2009) A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog 1(1):6

    Article  PubMed Central  PubMed  Google Scholar 

  • Relman DA (2012) The human microbiome: ecosystem resilience and health. Nutr Rev 70:S2–S9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Richardson LP, Lozano P, Russo J, McCauley E, Bush T, Katon W (2006) Asthma symptom burden: relationship to asthma severity and anxiety and depression symptoms. Pediatrics 118(3):1042–1051

    Article  PubMed  Google Scholar 

  • Rietveld S, van Beest I, Everaerd W (1999) Stress-induced breathlessness in asthma. Psychol Med 29(6):1359–1366

    Google Scholar 

  • Ritz T, Meuret AE, Trueba AF, Fritzsche A, von Leupoldt A (2013) Psychosocial factors and behavioral medicine interventions in asthma. J Consult Clin Psychol 81(2):231

    Article  PubMed  Google Scholar 

  • Rook GA (2009) Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis. Immunology 126(1):3–11

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rook GAW, Lowry CA (2008) The hygiene hypothesis and psychiatric disorders. Trends Immunol 29:150–158

    Article  CAS  PubMed  Google Scholar 

  • Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313–323

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sandberg S, Paton JR, Ahola S, McCann DC, McGuinness D, Hillary CR, Oja H (2000) The role of acute and chronic stress in asthma attacks in children. Lancet 356:982–987

    Article  CAS  PubMed  Google Scholar 

  • Schröder NWJ (2009) The role of innate immunity in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol 9:38–43

    Article  PubMed  CAS  Google Scholar 

  • Schröder NW, Crother TR, Naiki Y, Chen S, Wong MH, Yilmaz A, Arditi M (2008) Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol 122(3):595–602

    Google Scholar 

  • Scott KM, Von Korff M, Alonso J, Angermeyer MC, Benjet C, Bruffaerts R et al (2008) Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma. Psychosom Med 70(9):1035–1043

    Article  PubMed  Google Scholar 

  • Sekirov I, Finlay BB (2009) The role of the intestinal microbiota in enteric infection. J Physiol 587(17):4159–4167

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sharon G, Segal D, Ringo JM, Hefetz A, Zilber-Rosenberg I, Rosenberg E (2010) Commensal bacteria play a role in mating preference of Drosophila melanogaster. Proc Natl Acad Sci U S A 107(46):20051–20056

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Singh M, Ranjan Das R (2010) Probiotics for allergic respiratory diseases—putting it into perspective. Pediatr Allergy Immunol 21:368–376

    Article  Google Scholar 

  • Slattery MJ, Essex MJ (2011) Specificity in the association of anxiety, depression, and atopic disorders in a community sample of adolescents. J Psychiatr Res 45(6):788–795

    Article  PubMed Central  PubMed  Google Scholar 

  • Snyder HR (2013) Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol Bull 139(1):81

    Article  PubMed Central  PubMed  Google Scholar 

  • Sommer F, Bäckhed F (2013) The gut microbiota—masters of host development and physiology. Nat Rev Microbiol 11(4):227–238

    Article  CAS  PubMed  Google Scholar 

  • Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299(6710):1259

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sudo N (2012) Role of microbiome in regulating the HPA axis and its relevance to allergy. Chem Immunol Allergy 98:163–175

    Article  CAS  PubMed  Google Scholar 

  • Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu X-N, Kubo C, Koga Y (2004) Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice. J Physiol 558:263–275

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR (2008) A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy 38:629–633

    Article  CAS  PubMed  Google Scholar 

  • Tillisch K, Wang Z, Kilpatrick L, Holschneider DP, Mayer EA (2008) Studying the brain–gut axis with pharmacological imaging. Ann N Y Acad Sci 1144(1):256–264

    Article  CAS  PubMed  Google Scholar 

  • Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B et al (2013) Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 144(7):1394–1401

    Article  CAS  PubMed  Google Scholar 

  • Trueba AF, Ritz T (2013) Stress, asthma, and respiratory infections: pathways involving airway immunology and microbial endocrinology. Brain Behav Immun 29:11–27

    Article  CAS  PubMed  Google Scholar 

  • Trueba AF, Mizrachi D, Auchus RJ, Vogel PD, Ritz T (2012) Effects of psychosocial stress on the pattern of salivary protein release. Physiol Behav 105(3):841–849

    Article  CAS  PubMed  Google Scholar 

  • Umetsu DT, McIntire JJ, Akbari O, Macaubys C, DeKruyff RH (2002) Asthma an epidemic of dysregulated immunity. Nature 3:715–720

    CAS  Google Scholar 

  • Van Lieshout RJ, Bienenstock J, MacQueen GM (2009) A review of candidate pathways underlying the association between asthma and major depressive disorder. Psychosom Med 71(2):187–195

    Article  PubMed  Google Scholar 

  • Viswanathan VK (2014) The trendy microbes. Gut Microbes 5(4):439–440

    Article  CAS  PubMed  Google Scholar 

  • Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME (2008) Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. Ann Allergy Asthma Immunol 101(6):570–579

    Article  PubMed  Google Scholar 

  • Wamboldt MZ, Laudenslager M, Wamboldt FS, Kelsay K, Hewitt J (2003) Adolescents with atopic disorders have an attenuated cortisol response to laboratory stress. J Allergy Clin Immunol 111(3):509–514

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Kasper LH (2014) The role of microbiome in central nervous system disorders. Brain Behav Immun 38:1–12

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Wang X, Wang BR, Zhang XJ, Xu Z, Ding YQ, Ju G (2002) Evidences for vagus nerve in maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats. World J Gastroenterol 8(3):540–545

    Article  PubMed  PubMed Central  Google Scholar 

  • Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP (1998) Corticotropin-releasing hormone and inflammation. Ann N Y Acad Sci 840:21–32

    Article  CAS  PubMed  Google Scholar 

  • Wenzel SE (2006) Asthma: defining of the persistent adult phenotypes. Lancet 368(9537):804–813

    Article  CAS  PubMed  Google Scholar 

  • Wills-Karp M, Santeliz J, Karp CL (2001) Opinion: the germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 1:69–75

    Article  CAS  PubMed  Google Scholar 

  • Wong KO, Hunter Rowe B, Douwes J, Senthilselvan A (2013) Asthma and wheezing are associated with depression and anxiety in adults: an analysis from 54 countries. Pulm Med 2013:929028

    Article  PubMed Central  PubMed  Google Scholar 

  • Wright RJ (2007) Prenatal maternal stress and early caregiving experiences: implications for childhood asthma risk. Paediatr Perinat Epidemiol 21(s3):8–14

    Article  PubMed  Google Scholar 

  • Wright RJ (2010) Perinatal stress and early life programming of lung structure and function. Biol Psychol 84:46–56

    Article  PubMed Central  PubMed  Google Scholar 

  • Wright RJ, Visness CJ, Calatroni A, Grayson MH, Gold DR, Sandel MT, Lee-Parritz A, Wood RA, Kattan M, Bloomberg GR, Burger M, Togias A, Witter FR, Sperling RS, Sadovsky Y, Gern JE (2010) Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. Am J Respir Crit Care Med 182:25–33

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zhu Z, Oh SY, Zheng T, Kim YK (2010) Immunomodulating effects of endotoxin in mouse models of allergic asthma. Clin Exp Allergy 40:536–546

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Erick Moreno Montenegro for all the helpful comments.

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Trueba, A.F., Ritz, T., Trueba, G. (2016). The Role of the Microbiome in the Relationship of Asthma and Affective Disorders. In: Lyte, M. (eds) Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. Advances in Experimental Medicine and Biology(), vol 874. Springer, Cham. https://doi.org/10.1007/978-3-319-20215-0_13

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