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The Multidisciplinary Management of Early Stage Cervical Esophageal Cancer

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Esophageal Cancer

Abstract

Cancer development in the cervical portion of the esophagus presents a unique challenge to management given the close proximity of critical structures in the head and neck. Cervical esophageal cancer (CEC) was historically approached with primary surgery, pharyngo-laryngo-esophagectomy (PLE), but a paradigm shift has occurred such that functional organ preservation with concurrent chemotherapy and radiation (CRT) is now preferred. This chapter will review anatomical considerations pertinent to the management of CEC as well as the risk factors and multidisciplinary treatment approach to this disease.

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References

  1. Martins AS. Neck and mediastinal node dissection in pharyngolaryngoesophageal tumors. Head Neck. 2001;23(9):772–9.

    Article  CAS  PubMed  Google Scholar 

  2. Fujita H, Kakegawa T, Yamana H, Sueyoshi S, Hikita S, Mine T, Tanaka Y, Ishikawa H, Shirouzu K, Mori K, Inoue Y, Tanabe HY, Kiyokawa K, Tai Y, Inutsuka H. Total esophagectomy versus proximal esophagectomy for esophageal cancer at the cervicothoracic junction. World J Surg. 1999;23(5):486–91.

    Article  CAS  PubMed  Google Scholar 

  3. Mendenhall WM, Sombeck MD, Parsons JT, Kasper ME, Stringer SP, Vogel SB. Management of cervical esophageal carcinoma. Semin Radiat Oncol. 1994;4(3):179–91. doi:10.1053/SRAO00400179.

    Article  PubMed  Google Scholar 

  4. Collin CF, Spiro RH. Carcinoma of the cervical esophagus: changing therapeutic trends. Am J Surg. 1984;148(4):460–6.

    Article  CAS  PubMed  Google Scholar 

  5. Islami F, Boffetta P, Ren JS, Pedoeim L, Khatib D, Kamangar F. High-temperature beverages and foods and esophageal cancer risk–a systematic review. Int J Cancer J International du Cancer. 2009;125(3):491–524. doi:10.1002/ijc.24445.

    Article  CAS  Google Scholar 

  6. Liyanage SS, Rahman B, Ridda I, Newall AT, Tabrizi SN, Garland SM, Segelov E, Seale H, Crowe PJ, Moa A, Macintyre CR. The aetiological role of human papillomavirus in oesophageal squamous cell carcinoma: a meta-analysis. PLoS One. 2013;8(7), e69238. doi:10.1371/journal.pone.0069238.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35. doi:10.1056/NEJMoa0912217.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Grass GD, Cooper SL, Armeson K, Garrett-Mayer E, Sharma A. Cervical esophageal cancer: a population-based study. Head Neck. 2014. doi:10.1002/hed.23678.

    PubMed  Google Scholar 

  9. Daiko H, Hayashi R, Saikawa M, Sakuraba M, Yamazaki M, Miyazaki M, Ugumori T, Asai M, Oyama W, Ebihara S. Surgical management of carcinoma of the cervical esophagus. J Surg Oncol. 2007;96(2):166–72. doi:10.1002/jso.20795.

    Article  PubMed  Google Scholar 

  10. Heeren PA, Jager PL, Bongaerts F, van Dullemen H, Sluiter W, Plukker JT. Detection of distant metastases in esophageal cancer with (18)F-FDG PET. J Nucl Med Off Publ Soc Nucl Med. 2004;45(6):980–7.

    Google Scholar 

  11. Thosani N, Singh H, Kapadia A, Ochi N, Lee JH, Ajani J, Swisher SG, Hofstetter WL, Guha S, Bhutani MS. Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis. Gastrointest Endosc. 2012;75(2):242–53. doi:10.1016/j.gie.2011.09.016.

    Article  PubMed  Google Scholar 

  12. Chandawarkar RY, Kakegawa T, Fujita H, Yamana H, Toh Y, Fujitoh H. Endosonography for preoperative staging of specific nodal groups associated with esophageal cancer. World J Surg. 1996;20(6):700–2.

    Article  CAS  PubMed  Google Scholar 

  13. Zhao D, Gao X, Guan L, Su W, Gao J, Liu C, Luo X, Li X. Free jejunal graft for reconstruction of defects in the hypopharynx and cervical esophagus following the cancer resections. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2009;13(7):1368–72. doi:10.1007/s11605-009-0877-8.

    Article  Google Scholar 

  14. Peracchia A, Bardini R, Ruol A, Segalin A, Castoro C, Asolati M, Tiso E. Surgical management of carcinoma of the hypopharynx and cervical esophagus. Hepatogastroenterology. 1990;37(4):371–5.

    CAS  PubMed  Google Scholar 

  15. Gunnlaugsson GH, Wychulis AR, Roland C, Ellis Jr FH. Analysis of the records of 1,657 patients with carcinoma of the esophagus and cardia of the stomach. Surg Gynecol Obstet. 1970;130(6):997–1005.

    CAS  PubMed  Google Scholar 

  16. Peracchia A, Ancona E, Buin F. The surgical treatment of cancer of the cervical esophagus: complications and preliminary results. Int Surg. 1982;67(2):135–7.

    CAS  PubMed  Google Scholar 

  17. Pearson JG. Radiotherapy for esophageal carcinoma. World J Surg. 1981;5(4):489–97.

    Article  CAS  PubMed  Google Scholar 

  18. Tong DK, Law S, Kwong DL, Wei WI, Ng RW, Wong KH. Current management of cervical esophageal cancer. World J Surg. 2011;35(3):600–7. doi:10.1007/s00268-010-0876-7.

    Article  PubMed  Google Scholar 

  19. Wei WI, Lam LK, Yuen PW, Wong J. Current status of pharyngolaryngo-esophagectomy and pharyngogastric anastomosis. Head Neck. 1998;20(3):240–4.

    Article  CAS  PubMed  Google Scholar 

  20. Marmuse JP, Koka VN, Guedon C, Benhamou G. Surgical treatment of carcinoma of the proximal esophagus. Am J Surg. 1995;169(4):386–90.

    Article  CAS  PubMed  Google Scholar 

  21. Triboulet JP, Mariette C, Chevalier D, Amrouni H. Surgical management of carcinoma of the hypopharynx and cervical esophagus: analysis of 209 cases. Arch Surg. 2001;136(10):1164–70.

    Article  CAS  PubMed  Google Scholar 

  22. Wang HW, Chu PY, Kuo KT, Yang CH, Chang SY, Hsu WH, Wang LS. A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction. J Surg Oncol. 2006;93(6):468–76. doi:10.1002/jso.20472.

    Article  PubMed  Google Scholar 

  23. Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson Jr JA, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, Asbell SO, Graham MV, Leichman LL. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85–01). Radiation Therapy Oncology Group. JAMA. 1999;281(17):1623–7.

    Article  CAS  PubMed  Google Scholar 

  24. Bedenne L, Michel P, Bouche O, Milan C, Mariette C, Conroy T, Pezet D, Roullet B, Seitz JF, Herr JP, Paillot B, Arveux P, Bonnetain F, Binquet C. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25(10):1160–8. doi:10.1200/JCO.2005.04.7118.

    Article  CAS  Google Scholar 

  25. Prades JM, Lallemant B, Garrel R, Reyt E, Righini C, Schmitt T, Remini N, Saban-Roche L, Timoshenko AP, Trombert B, Guerrier B. Randomized phase III trial comparing induction chemotherapy followed by radiotherapy to concomitant chemoradiotherapy for laryngeal preservation in T3M0 pyriform sinus carcinoma. Acta Otolaryngol. 2010;130(1):150–5. doi:10.3109/00016480902914080.

    Article  CAS  PubMed  Google Scholar 

  26. Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourhis J, Pignon JP, Group M-CC. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2011;100(1):33–40. doi:10.1016/j.radonc.2011.05.036.

    Article  Google Scholar 

  27. Lefebvre JL, Andry G, Chevalier D, Luboinski B, Collette L, Traissac L, de Raucourt D, Langendijk JA, Head E, Neck Cancer G. Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891. Ann Oncol Off J Eur Soc Med Oncol/ESMO. 2012;23(10):2708–14. doi:10.1093/annonc/mds065.

    Article  Google Scholar 

  28. Bidoli P, Bajetta E, Stani SC, De CD, Santoro A, Valente M, Zucali R, Valagussa P, Ravasi G, Bonadonna G. Ten-year survival with chemotherapy and radiotherapy in patients with squamous cell carcinoma of the esophagus. Cancer. 2002;94(2):352–61. doi:10.1002/cncr.10233.

    Article  PubMed  Google Scholar 

  29. Schieman C, Wigle DA, Deschamps C, Nichols 3rd FC, Cassivi SD, Shen KR, Allen MS. Salvage resections for recurrent or persistent cancer of the proximal esophagus after chemoradiotherapy. Ann Thorac Surg. 2013;95(2):459–63. doi:10.1016/j.athoracsur.2012.10.028.

    Article  PubMed  Google Scholar 

  30. Ott K, Lordick F, Molls M, Bartels H, Biemer E, Siewert JR. Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus. Br J Surg. 2009;96(3):258–66. doi:10.1002/bjs.6437.

    Article  CAS  PubMed  Google Scholar 

  31. Burmeister BH, Dickie G, Smithers BM, Hodge R, Morton K. Thirty-four patients with carcinoma of the cervical esophagus treated with chemoradiation therapy. Arch Otolaryngol Head Neck Surg. 2000;126(2):205–8.

    Article  CAS  PubMed  Google Scholar 

  32. Yamada K, Murakami M, Okamoto Y, Okuno Y, Nakajima T, Kusumi F, Takakuwa H, Matsusue S. Treatment results of radiotherapy for carcinoma of the cervical esophagus. Acta Oncol. 2006;45(8):1120–5. doi:10.1080/02841860600609768.

    Article  PubMed  Google Scholar 

  33. Stuschke M, Stahl M, Wilke H, Walz MK, Oldenburg AR, Stuben G, Jahnke K, Seeber S, Sack H. Induction chemotherapy followed by concurrent chemotherapy and high-dose radiotherapy for locally advanced squamous cell carcinoma of the cervical oesophagus. Oncology. 1999;57(2):99–105. doi:12015.

    Google Scholar 

  34. Gkika E, Gauler T, Eberhardt W, Stahl M, Stuschke M, Pottgen C. Long-term results of definitive radiochemotherapy in locally advanced cancers of the cervical esophagus. Dis Esophagus Off J Int Soc Dis Esophagus/ISDE. 2014;27(7):678–84. doi:10.1111/dote.12146.

    Article  CAS  Google Scholar 

  35. Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA, Kelsen DP. INT 0123 (Radiation Therapy Oncology Group 94–05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(5):1167–74.

    Article  CAS  Google Scholar 

  36. Huang SH, Lockwood G, Brierley J, Cummings B, Kim J, Wong R, Bayley A, Ringash J. Effect of concurrent high-dose cisplatin chemotherapy and conformal radiotherapy on cervical esophageal cancer survival. Int J Radiat Oncol Biol Phys. 2008;71(3):735–40. doi:10.1016/j.ijrobp.2007.10.022.

    Article  CAS  PubMed  Google Scholar 

  37. Cao C, Luo J, Gao L, Xu G, Yi J, Huang X, Wang K, Zhang S, Qu Y, Li S, Xiao J, Zhang Z. Definitive radiotherapy for cervical esophageal cancer. Head Neck. 2015;37(2):151–5. doi:10.1002/hed.23572.

    Article  PubMed  Google Scholar 

  38. van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A, Group C. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012;366(22):2074–84. doi:10.1056/NEJMoa1112088.

    Article  PubMed  Google Scholar 

  39. Fenkell L, Kaminsky I, Breen S, Huang S, Van Prooijen M, Ringash J. Dosimetric comparison of IMRT vs. 3D conformal radiotherapy in the treatment of cancer of the cervical esophagus. Radiother Oncol J Eur Soc Thera Radiol Oncol. 2008;89(3):287–91. doi:10.1016/j.radonc.2008.08.008.

    Article  Google Scholar 

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Correspondence to Manisha Palta MD .

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Salama, J.K., Palta, M., Torok, J.A. (2015). The Multidisciplinary Management of Early Stage Cervical Esophageal Cancer. In: Saba, N., El-Rayes, B. (eds) Esophageal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-20068-2_11

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  • DOI: https://doi.org/10.1007/978-3-319-20068-2_11

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20067-5

  • Online ISBN: 978-3-319-20068-2

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