Abstract
All enzymes in a metabolic pathway operating in steady state have the same flux and maintain concentrations of all intermediates. The system will respond to perturbation in such a way that the perturbation is counteracted. This results in homeostasis. Cells can change the flux through a pathway by changing enzyme concentration, switching enzymes on or off by posttranslational modification, allosteric control, and catalytic cycling.
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Buxbaum, E. (2015). The Flow of Metabolites Through Metabolic Pathways. In: Fundamentals of Protein Structure and Function. Springer, Cham. https://doi.org/10.1007/978-3-319-19920-7_9
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DOI: https://doi.org/10.1007/978-3-319-19920-7_9
Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-19920-7
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