Abstract
Both hyperbolic and sigmoidal kinetics result in a gradual change of enzymatic activity with substrate concentration. Activation cascades, where upon a signal one enzyme activates another, which in turn activates yet another, allow switch-like, all-or-nothing responses. A cell either enters mitosis, or it doesn’t. A liver cell either does glycolysis or it does gluconeogenesis. This behaviour more than signal amplification is the physiological role of such cascades.
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Buxbaum, E. (2015). Enzyme Kinetics: Special Cases. In: Fundamentals of Protein Structure and Function. Springer, Cham. https://doi.org/10.1007/978-3-319-19920-7_8
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DOI: https://doi.org/10.1007/978-3-319-19920-7_8
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-19919-1
Online ISBN: 978-3-319-19920-7
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