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Amyloidosis of the Lymph Nodes and the Spleen

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Amyloid and Related Disorders

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Lymph node and spleen involvement is frequent in systemic amyloidosis. AL amyloidosis is the most common and clinically most important cause of lymph node amyloidosis. In most cases, the lymph node AL amyloidosis is systemic and caused by an underlying systemic plasma cell or B-cell neoplasm. For this reason, immunophenotypic analysis of the lymphoid component is required in these cases for management decisions. Other etiologies of lymph node amyloidosis include AA amyloidosis and rarely hereditary amyloidoses such as AAPOA1 or ATTR amyloidosis. By imaging studies, the spleen is involved in most cases of systemic AL and AA amyloidosis. Clinically splenic involvement may lead to hyposplenism, and occasionally, splenic rupture. In addition to AL and AA, amyloidosis and other systemic amyloidoses such as ALECT2 amyloidosis can also affect the spleen.

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Filiz Sen MD

  2. Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Ahmet Dogan MD, PhD

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  1. Filiz Sen MD
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  2. Ahmet Dogan MD, PhD
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Correspondence to Ahmet Dogan MD, PhD .

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Editors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA

    Maria M. Picken

  2. Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA

    Guillermo A. Herrera

  3. Department of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, New York, New York, USA

    Ahmet Dogan

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Sen, F., Dogan, A. (2015). Amyloidosis of the Lymph Nodes and the Spleen. In: Picken, M., Herrera, G., Dogan, A. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-19294-9_32

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  • DOI: https://doi.org/10.1007/978-3-319-19294-9_32

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-19293-2

  • Online ISBN: 978-3-319-19294-9

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