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Dietary Essential Oils and Cancer Chemopreventive Potential

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Bioactive Essential Oils and Cancer

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Abstract

As cancer development is usually a long process, there is a large window of opportunity to establish prevention strategies that should focus on several environmental factors including nutrition. Cancer chemoprevention with dietary bioactive food components (BFCs) represents a promising strategy to prevent the disease. Dietary essential oils from fruits, vegetables, herbs, and spices represent interesting sources of BFCs with cancer chemopreventive potential. One of its main BFCs is represented by isoprenic derivatives (terpenes and terpenoids) including mainly monoterpenes and sesquiterpenes. Isoprenic derivatives represent one of the most diverse class of natural products produced by plants, with more than 40,000 members identified. Among them, monoterpene geraniol (lemon, lime, orange, and ginger) and sesquiterpene farnesol (lemongrass and chamomile) represent promising essential oil components with cancer chemopreventive potential. They have elicited protective effects in both in vitro and in vivo model systems. Accumulating evidence show that in addition to HMG-CoA reductase, geraniol and farnesol present other molecular targets including NFkB, Cox-2, and antioxidant enzymes. Their low toxicity and regular consumption through diet are further characteristics that reinforce their role as cancer chemopreventive agents. Importantly, bioavailability, metabolism, safety, and mechanism of action are aspects that should be deeply investigated, especially in clinical trials.

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References

  • Ahmad ST, Arjumand W, Seth A, Nafees S, Rashid S, Ali N, Sultana S (2011) Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways. Toxicology 290:69–81

    Article  CAS  PubMed  Google Scholar 

  • Baena Ruiz R, Salinas Hernandez P (2014) Diet and cancer: risk factors and epidemiological evidence. Maturitas 77:202–208

    Article  CAS  PubMed  Google Scholar 

  • Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils—a review. Food Chem Toxicol 46:446–475

    Article  CAS  PubMed  Google Scholar 

  • Beaglehole R, Bonita R, Magnusson R (2011) Global cancer prevention: an important pathway to global health and development. Public Health 125:821–831

    Article  CAS  PubMed  Google Scholar 

  • Bianco AM, Zanin V, Marcuzzi A, Crovella S (2012) Clarification of the pleiotropic effects of statins on mevalonate pathway and the feedback regulation of isoprenoids requires more comprehensive investigation. Cell Biochem Funct 30:176

    Article  CAS  PubMed  Google Scholar 

  • Blum R, Cox AD, Kloog Y (2008) Inhibitors of chronically active ras: potential for treatment of human malignancies. Recent Pat Anticancer Drug Discov 3:31–47

    Article  CAS  PubMed  Google Scholar 

  • Bostedor RG, Karkas JD, Arison BH, Bansal VS, Vaidya S, Germershausen JI, Kurtz MM, Bergstrom JD (1997) Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. J Biol Chem 272:9197–9203

    Article  CAS  PubMed  Google Scholar 

  • Burke YD, Stark MJ, Roach SL, Sen SE, Crowell PL (1997) Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids 32:151–156

    Article  CAS  PubMed  Google Scholar 

  • Cardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS (2011) Chemopreventive effects of beta-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 22:130–135

    Article  CAS  PubMed  Google Scholar 

  • Carnesecchi S, Bradaia A, Fischer B, Coelho D, Scholler-Guinard M, Gosse F, Raul F (2002) Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. J Pharmacol Exp Ther 303:711–715

    Article  CAS  PubMed  Google Scholar 

  • Carnesecchi S, Bras-Goncalves R, Bradaia A, Zeisel M, Gosse F, Poupon MF, Raul F (2004) Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett 215:53–59

    Article  CAS  PubMed  Google Scholar 

  • Chadha A, Madyastha KM (1984) Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. Xenobiotica 14:365–374

    Article  CAS  PubMed  Google Scholar 

  • Chagas CE, Vieira A, Ong TP, Moreno FS (2009) Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats. Acta Cir Bras 24:377–382

    Article  PubMed  Google Scholar 

  • Chaudhary SC, Alam MS, Siddiqui MS, Athar M (2009) Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. Life Sci 85:196–205

    Article  CAS  PubMed  Google Scholar 

  • Chaudhary SC, Siddiqui MS, Athar M, Alam MS (2013) Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. J Appl Toxicol 33:828–837

    Article  CAS  PubMed  Google Scholar 

  • Chen W, Viljoen AM (2010) Geraniol—a review of a commercially important fragrance material. S Afr J Bot 76:643–651

    Article  CAS  Google Scholar 

  • Crespo R, Montero Villegas S, Abba MC, de Bravo MG, Polo MP (2013) Transcriptional and posttranscriptional inhibition of HMGCR and PC biosynthesis by geraniol in 2 Hep-G2 cell proliferation linked pathways. Biochem Cell Biol 91:131–139

    Article  CAS  PubMed  Google Scholar 

  • Crowell PL (1999) Prevention and therapy of cancer by dietary monoterpenes. J Nutr 129(3):775s–778s

    CAS  PubMed  Google Scholar 

  • Danilo C, Frank PG (2012) Cholesterol and breast cancer development. Curr Opin Pharmacol 12:677–682

    Article  CAS  PubMed  Google Scholar 

  • Duncan RE, Archer MC (2006) Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. Biochem Biophys Res Commun 343:239–243

    Article  CAS  PubMed  Google Scholar 

  • Duncan RE, Lau D, El-Sohemy A, Archer MC (2004) Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem Pharmacol 68:1739–1747

    Article  CAS  PubMed  Google Scholar 

  • Elson CE, Yu SG (1994) The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables. J Nutr 124:607–614

    CAS  PubMed  Google Scholar 

  • Elson CE, Underbakke GL, Hanson P, Shrago E, Wainberg RH, Qureshi AA (1989) Impact of lemongrass oil, an essential oil, on serum cholesterol. Lipids 24:677–679

    Article  CAS  PubMed  Google Scholar 

  • Elson CE, Peffley DM, Hentosh P, Mo H (1999) Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. Proc Soc Exp Biol Med 221:294–311

    Article  CAS  PubMed  Google Scholar 

  • Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81:687–693

    Article  CAS  PubMed  Google Scholar 

  • Fritz G (2009) Targeting the mevalonate pathway for improved anticancer therapy. Curr Cancer Drug Targets 9:626–638

    Article  CAS  PubMed  Google Scholar 

  • Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425–430

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez-Vallinas M, Gonzalez-Castejon M, Rodriguez-Casado A, Ramirez de Molina A (2013) Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives. Nutr Rev 71:585–599

    Article  PubMed  Google Scholar 

  • Horn TL, Long L, Cwik MJ, Morrissey RL, Kapetanovic IM, McCormick DL (2005) Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. Chem Biol Interact 152:79–99

    Article  CAS  PubMed  Google Scholar 

  • Joo JH, Jetten AM (2010) Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett 287:123–135

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Joo JH, Liao G, Collins JB, Grissom SF, Jetten AM (2007) Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. Cancer Res 67:7929–7936

    Article  CAS  PubMed  Google Scholar 

  • Keller RK, Zhao Z, Chambers C, Ness GC (1996) Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. Arch Biochem Biophys 328:324–330

    Article  CAS  PubMed  Google Scholar 

  • Khan R, Sultana S (2011) Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem Biol Interact 192:193–200

    Article  CAS  PubMed  Google Scholar 

  • Khan AQ, Khan R, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK, Sultana S (2013) Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-kappaB. Exp Mol Pathol 94:419–429

    Article  CAS  PubMed  Google Scholar 

  • Kim YS, Milner JA (2011) Bioactive food components and cancer-specific metabonomic profiles. J Biomed Biotechnol 2011:721213

    PubMed Central  PubMed  Google Scholar 

  • Kim SH, Bae HC, Park EJ, Lee CR, Kim BJ, Lee S, Park HH, Kim SJ, So I, Kim TW, Jeon JH (2011) Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochem Biophys Res Commun 407:129–134

    Article  CAS  PubMed  Google Scholar 

  • Kim SH, Park EJ, Lee CR, Chun JN, Cho NH, Kim IG, Lee S, Kim TW, Park HH, So I, Jeon JH (2012) Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. Int J Oncol 40:1683–1690

    CAS  PubMed  Google Scholar 

  • Lapczynski A, Bhatia SP, Foxenberg RJ, Letizia CS, Api AM (2008a) Fragrance material review on geraniol. Food Chem Toxicol 46 (Suppl. 11):S160–170

    Article  CAS  PubMed  Google Scholar 

  • Lapczynski A, Bhatia SP, Letizia CS, Api AM (2008b) Fragrance material review on farnesol. Food Chem Toxicol 46 (Suppl. 11):S149–S156

    Article  CAS  PubMed  Google Scholar 

  • Liu RH (2013) Dietary bioactive compounds and their health implications. J Food Sci 78 (­Suppl. 1):A18–A25

    Article  CAS  PubMed  Google Scholar 

  • Madankumar A, Jayakumar S, Gokuladhas K, Rajan B, Raghunandhakumar S, Asokkumar S, Devaki T (2013) Geraniol modulates tongue and hepatic phase I and phase II conjugation ­activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis. Eur J Pharmacol 705:148–155

    Article  CAS  PubMed  Google Scholar 

  • Martin C, Zhang Y, Tonelli C, Petroni K (2013) Plants, diet, and health. Annu Rev Plant Biol 64:19–46

    Article  CAS  PubMed  Google Scholar 

  • Meigs TE, Roseman DS, Simoni RD (1996) Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. J Biol Chem 271:7916–7922

    Article  CAS  PubMed  Google Scholar 

  • Miller JA, Hakim IA, Chew W, Thompson P, Thomson CA, Chow HH (2010) Adipose tissue accumulation of d-limonene with the consumption of a lemonade preparation rich in d-limonene content. Nutr Cancer 62:783–788

    Article  CAS  PubMed  Google Scholar 

  • Miller JA, Lang JE, Ley M, Nagle R, Hsu CH, Thompson PA, Cordova C, Waer A, Chow HH (2013) Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. Cancer Prev Res 6:577–584

    Article  CAS  Google Scholar 

  • Milner JA (2008) Nutrition and cancer: essential elements for a roadmap. Cancer Lett 269:189–198

    Article  CAS  PubMed  Google Scholar 

  • Mo H, Elson CE (2004) Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp Biol Med 229:567–585

    CAS  Google Scholar 

  • Moreno FS, Rossiello MR, Manjeshwar S, Nath R, Rao PM, Rajalakshmi S, Sarma DS (1995) Effect of beta-carotene on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver. Cancer Lett 96:201–208

    Article  CAS  PubMed  Google Scholar 

  • Ong TP, Heidor R, de Conti A, Dagli ML, Moreno FS (2006) Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Carcinogenesis 27:1194–1203

    Article  CAS  PubMed  Google Scholar 

  • Ong TP, Moreno FS, Ross SA (2011) Targeting the epigenome with bioactive food components for cancer prevention. J Nutrigenet Nutrigenomics 4:275–292

    Article  CAS  PubMed  Google Scholar 

  • Ong TP, Cardozo MT, de Conti A, Moreno FS (2012) Chemoprevention of hepatocarcinogenesis with dietary isoprenic derivatives: cellular and molecular aspects. Curr Cancer Drug Targets 12:1173–1190

    CAS  PubMed  Google Scholar 

  • Peffley DM, Gayen AK (2003) Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J Nutr 133:38–44

    CAS  PubMed  Google Scholar 

  • Polo MP, Crespo R, de Bravo MG (2011) Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. Cell Biochem Funct 29:452–458

    Article  CAS  PubMed  Google Scholar 

  • Qamar W, Khan AQ, Khan R, Lateef A, Tahir M, Rehman MU, Ali F, Sultana S (2012) Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. Exp Lung Res 38:19–27

    Article  CAS  PubMed  Google Scholar 

  • Rabi T, Bishayee A (2009) Terpenoids and breast cancer chemoprevention. Breast Cancer Res Treat 115:223–239

    Article  CAS  PubMed  Google Scholar 

  • Rabi T, Gupta S (2008) Dietary terpenoids and prostate cancer chemoprevention. Front Biosci 13:3457–3469

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rao CV, Newmark HL, Reddy BS (2002) Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis. Cancer Detect Prev 26:419–425

    Article  CAS  PubMed  Google Scholar 

  • Seo KA, Kim H, Ku HY, Ahn HJ, Park SJ, Bae SK, Shin JG, Liu KH (2008) The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity. Chem Biol Interact 174:141–146

    Article  CAS  PubMed  Google Scholar 

  • Shoff SM, Grummer M, Yatvin MB, Elson CE (1991) Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol. Cancer Res 51:37–42

    CAS  PubMed  Google Scholar 

  • Singh BK, Tripathi M, Chaudhari BP, Pandey PK, Kakkar P (2012) Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. PloS One 7:e34200

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35:1332–1338

    CAS  PubMed  Google Scholar 

  • Steward WP, Brown K (2013) Cancer chemoprevention: a rapidly evolving field. Brit J Cancer 109:1–7

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768–780

    Article  CAS  PubMed  Google Scholar 

  • Thoppil RJ, Bishayee A (2011) Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World J Hepatol 3:228–249

    Article  PubMed Central  PubMed  Google Scholar 

  • Tiwari M, Kakkar P (2009) Plant derived antioxidants—Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol In Vitro 23:295–301

    Article  CAS  PubMed  Google Scholar 

  • Vieira A, Heidor R, Cardozo MT, Scolastici C, Purgatto E, Shiga TM, Barbisan LF, Ong TP, Moreno FS (2011) Efficacy of geraniol but not of beta-ionone or their combination for the chemoprevention of rat colon carcinogenesis. Braz J Med Biol Res 44:538–545

    Article  CAS  PubMed  Google Scholar 

  • Vineis P, Wild CP (2014) Global cancer patterns: causes and prevention. Lancet 383:549–557

    Article  PubMed  Google Scholar 

  • Vinothkumar V, Manoharan S (2011) Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Redox Rep 16:91–100

    Article  CAS  PubMed  Google Scholar 

  • Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V (2012) Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Mol Cell Biochem 369:17–25

    Article  CAS  PubMed  Google Scholar 

  • Vuch J, Marcuzzi A, Zanin V, Crovella S (2012) Comments to the editor concerning the paper entitled “Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways”. Toxicology 293(1–3):123–124

    Article  CAS  PubMed  Google Scholar 

  • Wagner KH, Elmadfa I (2003) Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes. Ann Nutr Metab 47:95–106

    Article  CAS  PubMed  Google Scholar 

  • Westfall D, Aboushadi N, Shackelford JE, Krisans SK (1997) Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. Biochem Biophys Res Commun 230:562–568

    Article  CAS  PubMed  Google Scholar 

  • Wiseman DA, Werner SR, Crowell PL (2007) Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther 320:1163–1170

    Article  CAS  PubMed  Google Scholar 

  • World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity and the prevention of cancer a global perspective. American Institute for Cancer Research, Washington

    Google Scholar 

  • Yang H, Dou QP (2010) Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer. Curr Drug Targets 11:733–744

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Yu SG, Hildebrandt LA, Elson CE (1995) Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J Nutr 125:2763–2767

    CAS  PubMed  Google Scholar 

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Acknowledgment

T.P. Ong laboratory is supported by grants and fellowships from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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  1. Laboratory of Nutrigenomics and Programming, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo and Food Research Center (CEPID/FAPESP), São Paulo, Brazil

    Thomas Prates Ong

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Correspondence to Thomas Prates Ong .

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  1. Federal University of Paraiba, João Pessoa, Paraíba, Brazil

    Damião Pergentino de Sousa

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Ong, T. (2015). Dietary Essential Oils and Cancer Chemopreventive Potential. In: de Sousa, D. (eds) Bioactive Essential Oils and Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-19144-7_12

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