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Hyperbranched Polydendrons

A New Macromolecular Architecture

  • Book
  • © 2015

Overview

Authors:
  1. Fiona L. Hatton

    1. Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden

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  • Nominated as an outstanding PhD thesis by the University of Liverpool, UK
  • Describes the development of a new class of materials, hyperbranched polydendrons
  • Examines hyperbranched polydendrons that formed nanoparticles with controlled size and functionality
  • Includes preliminary pharmacological evaluations, revealing that the particles formed are nontoxic and could potentially be used in orally administrated nanomedicines
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Introduction

    • Fiona L. Hatton
    Pages 1-34

  3. Synthesis and Characterisation of Hyp-polydendron Materials and Subsequent Nanoparticle Formation

    • Fiona L. Hatton
    Pages 35-77

  4. Mixing Dendron and PEG Initiators for the Polymerisation of Branched pHPMA and Aqueous Nanoparticle Formation

    • Fiona L. Hatton
    Pages 79-116

  5. Mixing Dendron and PEG Initiators for the Polymerisation of Branched pHPMA and Formation of Sterically Stabilised Nanoparticles

    • Fiona L. Hatton
    Pages 117-170

  6. Hyp-polydendrons; Studies of Nanoprecipitation Behaviour

    • Fiona L. Hatton
    Pages 171-198

  7. Conclusions and Future Work

    • Fiona L. Hatton
    Pages 199-206

  8. Experimental

    • Fiona L. Hatton
    Pages 207-226

  9. Back Matter

    Pages 227-260
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Keywords

About this book

This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.

Authors and Affiliations

  • Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden

    Fiona L. Hatton

About the author

Dr. Fiona L. Hatton obtained a 1st class MChem degree in medicinal chemistry and pharmacology from the University of Liverpool, UK, 2010. She received her PhD in 2014 from the same university, under the supervision of Prof. Steve Rannard, specializing in polymer chemistry, more specifically hyperbranched polydendrons. Fiona joined the division of Coating Technology, KTH Royal Institute of Technology, Sweden in 2014 as a postdoctoral researcher working for associate professor Anna Carlmark.

Bibliographic Information

  • Book Title: Hyperbranched Polydendrons

  • Book Subtitle: A New Macromolecular Architecture

  • Authors: Fiona L. Hatton

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-18753-2

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-18752-5Published: 01 June 2015

  • Softcover ISBN: 978-3-319-36979-2Published: 09 October 2016

  • eBook ISBN: 978-3-319-18753-2Published: 18 May 2015

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XXII, 260

  • Number of Illustrations: 209 b/w illustrations, 9 illustrations in colour

  • Topics: Medicinal Chemistry, Polymer Sciences, Nanochemistry

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