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TRP Channels in Cold Transduction

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TRP Channels in Sensory Transduction

Abstract

In the somatosensory system, cold thermoreceptor neurons and cold nociceptors are responsible for the detection of environmental low temperatures. The underlying machinery is far from simple; it is a result of the participation of several classes of transduction and voltage-gated ion channels that functionally coexist to give shape to the cold-induced receptor potential and subsequent action potential firing in response to cold stimulation. The cold-induced electrical responses begin in the free nerve endings of these sensory neurons, where a subgroup of thermosensitive Transient Receptor Potential channels (thermoTRPs) plays a critical role. These channels have evolved as molecular thermal sensors activated by a wide range of cold temperatures, and they have been proposed as key elements of the transduction machinery responsible for detection of environmental cold in primary somatosensory neurons. In this chapter, we summarize the most important functional properties of the primary sensory neurons involved in cutaneous cold detection, and the corresponding role of the thermoTRP channels TRPM8, TRPA1 and TRPC5 in cold transduction.

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Acknowledgements

Supported by Grants CONICYT Anillo ACT-1113 (RM, MP, GU), FONDECYT 1131064 (RM), FONDECYT 11130144 (MP) and FONDECYT 3150431 (AG). We thank Dr. Carlos Belmonte and Dr. Annika Mälkiä for comments to the manuscript. We apologise for omission of relevant work due to space constraints. RP hold a PhD fellowship from CONICYT. We thank the support of VRIDEI-USACH.

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  1. Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Avenida Libertador Bernardo O’Higgins nº3363, Estación Central, 9160000, Santiago, Chile

    Alejandro González, Gonzalo Ugarte, Ricardo Piña, María Pertusa & Rodolfo Madrid

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  1. Alejandro González
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  2. Gonzalo Ugarte
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  3. Ricardo Piña
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  4. María Pertusa
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  5. Rodolfo Madrid
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Correspondence to Rodolfo Madrid .

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  1. Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile

    Rodolfo Madrid

  2. Faculty of Science, University of Chile, Santiago, Chile

    Juan Bacigalupo

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González, A., Ugarte, G., Piña, R., Pertusa, M., Madrid, R. (2015). TRP Channels in Cold Transduction. In: Madrid, R., Bacigalupo, J. (eds) TRP Channels in Sensory Transduction. Springer, Cham. https://doi.org/10.1007/978-3-319-18705-1_9

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