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Drosophila Models of Cardiac Aging and Disease

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Life Extension

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 3))

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Abstract

Cardiac dysfunction is a critical problem in the aging population, with heart disease the number one cause of death in humans. While much has been learned about the characteristics of the aging heart from human longitudinal and cohort studies, as well as from vertebrate animal models, substantial logistical obstacles exist to the study of these phenomena in long-lived animals or humans. The emergence of Drosophila as a short-lived model system for studying cardiac function across ages has thus been an important factor in boosting understanding of conserved changes during cardiac aging. Here we discuss established and emerging methodology for assessment of cardiac function in Drosophila and review conserved changes to function during normal aging that have been observed in flies. We also review genetic factors contributing to cardiac aging that have been identified and studied using these techniques, including genes involved in stress response, contractile function, ion exchange, and nutrient sensing. Further, we discuss the use of Drosophila to study longitudinal effects of environmental interventions, such as exercise, on cardiac function. Lastly, we compare transcriptional changes induced by various methods of longevity extension in Drosophila and point out common pathways induced by selective breeding, exercise and dietary restriction.

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Acknowledgments

We thank Gerald Dorn for use of unpublished images, and Rolf Bodmer and Leah Cannon for helpful and generous discussion prior to publication.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Wayne State University, Detroit, MI, 48201, USA

    Alyson Sujkowski & Robert Wessells

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  1. Alyson Sujkowski
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  2. Robert Wessells
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Correspondence to Robert Wessells .

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Editors and Affiliations

  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Kievs'ka, Ukraine

    Alexander M. Vaiserman

  2. Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Komi Republic, Russia

    Alexey A. Moskalev

  3. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena G. Pasyukova

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Sujkowski, A., Wessells, R. (2015). Drosophila Models of Cardiac Aging and Disease. In: Vaiserman, A., Moskalev, A., Pasyukova, E. (eds) Life Extension. Healthy Ageing and Longevity, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-319-18326-8_6

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