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Integrating Tissue Microenvironment with Scaffold Design to Promote Immune-Mediated Regeneration

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Biomaterials in Regenerative Medicine and the Immune System

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Abstract

The role of tissue and immune microenvironments has played a large role in fields such as tumor immunology. Recently, there has been interest in the role of the immune microenvironment in tissue engineering, more specifically how that environment can influence regeneration. Immune cells secrete a diverse repertoire of signaling molecules that can influence other immune cells as well as surrounding parenchyma. In regenerating tissues, these signaling molecules become very important in tissue growth and differentiation. In vitro studies include the role of a scaffold in macrophage polarization, a critical determinant in regenerative success. In vivo innate and adaptive immune responses to varying scaffolds give us insights into the correct scaffold to choose for the goal tissue to be regenerated. By combining the optimum regenerative immune environment with the innate polarization tendencies of scaffolds, we will be better able to cater specific scaffolds to their applications and improve clinical outcomes.

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Author information

Authors and Affiliations

  1. Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Smith Building Rm. 5035, 400 N Broadway, 21231, Baltimore, MD, USA

    Jennifer H. Elisseeff Ph.D.

  2. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 21231, Baltimore, MD, USA

    Franck Housseau & Drew Pardoll

  3. Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, 21287, Baltimore, MD, USA

    Kaitlyn Sadtler

Authors
  1. Kaitlyn Sadtler
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  2. Franck Housseau
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  3. Drew Pardoll
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  4. Jennifer H. Elisseeff Ph.D.
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Corresponding author

Correspondence to Jennifer H. Elisseeff Ph.D. .

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Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Laura Santambrogio

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Sadtler, K., Housseau, F., Pardoll, D., Elisseeff, J. (2015). Integrating Tissue Microenvironment with Scaffold Design to Promote Immune-Mediated Regeneration. In: Santambrogio, L. (eds) Biomaterials in Regenerative Medicine and the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-18045-8_3

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