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Abstract

Proliferative vitreoretinopathy (PVR) is the clinical syndrome associated with retinal traction and detachment in which cells with proliferative potential multiply and contract on retinal surfaces and in the vitreous compartment. PVR presents with a broad spectrum of severity ranging from subtle retinal wrinkling to a total rigid retinal detachment, retinal shortening, and advanced periretinal proliferation. Although surgical reattachment of retinas associated with PVR can now be achieved in most cases, visual results remain disappointing. Therefore, prevention through early recognition of risk factors and subtle signs of PVR and appropriate modification of standard surgical techniques for retinal detachment remain of great importance.

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References

  1. Glaser BM, Cardin A, Biscoe B. Proliferative vitreoretinopathy. The mechanism of development of vitreoretinal traction. Ophthalmology. 1987;94(4):327–32.

    Article  CAS  PubMed  Google Scholar 

  2. Campochiaro PA. Pathogenic mechanisms in proliferative vitreoretinopathy. Arch Ophthalmol. 1997;115(2):237–41.

    Article  CAS  PubMed  Google Scholar 

  3. Guidry C. The role of Müller cells in fibrocontractive retinal disorders. Prog Retin Eye Res. 2005;24(1):75–86.

    Article  CAS  PubMed  Google Scholar 

  4. Ryan SJ. Retina. 5th ed. Philadelphia: Mosby; 2013.

    Google Scholar 

  5. Hui Y, Shi Y, Zhang X, Yang K, Yu C. TNF-alpha, IL-8 and IL-6 in the early inflammatory stage of experimental PVR model induced by macrophages. Zhonghua Yan Ke Za Zhi. 1999;35(2):140–3.

    CAS  PubMed  Google Scholar 

  6. Charteris DG, Sethi CS, Lewis GP, Fisher SK. Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology. Eye (Lond). 2002;16(4):369–74.

    Article  CAS  Google Scholar 

  7. Girard P, Mimoun G, Karpouzas I, Montefiore G. Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery. Retina (Phila PA). 1994;14(5):417–24.

    Article  CAS  Google Scholar 

  8. Yanyali A, Bonnet M. Risk factors of postoperative proliferative vitreoretinopathy in giant tears. J Fr Ophtalmol. 1996;19(3):175–80.

    CAS  PubMed  Google Scholar 

  9. Bonnet M, Guenoun S. Surgical risk factors for severe postoperative proliferative vitreoretinopathy (PVR) in retinal detachment with grade B PVR. Graefes Arch Clin Exp Ophthalmol. 1995;233(12):789–91.

    Article  CAS  PubMed  Google Scholar 

  10. The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1983;90(2):121–5.

    Google Scholar 

  11. Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM. An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol. 1991;112(2):159–65.

    Article  CAS  PubMed  Google Scholar 

  12. Aaberg TM. Surgery as the primary management of proliferative vitreoretinopathy: a history reflecting my experiences and biases. Arch Ophthalmol. 2010;128(8):1068–70.

    Article  PubMed  Google Scholar 

  13. Oyagi T, Emi K. Vitrectomy without scleral buckling for proliferative vitreoretinopathy. Retina (Phila PA). 2004;24(2):215–8.

    Article  Google Scholar 

  14. Joussen AM, Kirchhof B, Schrage N, Ocklenburg C, Hilgers R-D, HSO Study Group. Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO study): design issues and implications. Acta Ophthalmol Scand. 2007;85(6):623–30.

    Article  PubMed  Google Scholar 

  15. Beekhuis WH, Ando F, Zivojnović R, Mertens DA, Peperkamp E. Basal iridectomy at 6 o’clock in the aphakic eye treated with silicone oil: prevention of keratopathy and secondary glaucoma. Br J Ophthalmol. 1987;71(3):197–200.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Furino C, Micelli Ferrari T, Boscia F, Cardascia N, Recchimurzo N, Sborgia C. Triamcinolone-assisted pars plana vitrectomy for proliferative vitreoretinopathy. Retina (Phila PA). 2003;23(6):771–6.

    Article  Google Scholar 

  17. Jonas JB, Söfker A, Hayler J, Degenring RF. Intravitreal crystalline triamcinolone acetonide as an additional tool in pars plana vitrectomy for complicated proliferative vitreoretinopathy? Acta Ophthalmol Scand. 2003;81(6):663–5.

    Article  PubMed  Google Scholar 

  18. Feron EJ, Veckeneer M, Parys-Van Ginderdeuren R, Van Lommel A, Melles GRJ, Stalmans P. Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy. Arch Ophthalmol. 2002;120(2):141–4.

    Article  PubMed  Google Scholar 

  19. Teba FA, Mohr A, Eckardt C, Wong D, Kusaka S, Joondeph BC, et al. Trypan blue staining in vitreoretinal surgery. Ophthalmology. 2003;110(12):2409–12.

    Article  PubMed  Google Scholar 

  20. García-Arumí J, Corcostegui B, Tallada N. Subretinal membranes in proliferative vitreoretinopathy. An immunohistochemical study. Retina (Phila PA). 1992;12(3 Suppl):S55–9.

    Google Scholar 

  21. Lewis H, Aaberg TM, Abrams GW, McDonald HR, Williams GA, Mieler WF. Subretinal membranes in proliferative vitreoretinopathy. Ophthalmology. 1989;96(9):1403–14; discussion 1414–5.

    Article  CAS  PubMed  Google Scholar 

  22. Richards SC, Maberley AL. Complications of retinotomies for subretinal fluid drainage. Can J Ophthalmol. 1993;28(1):24–7.

    CAS  PubMed  Google Scholar 

  23. Pastor JC, Méndez MC, de la Fuente MA, Coco RM, García-Arumí J, Rodríguez de la Rúa E, et al. Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening. Ophthalmic Res. 2006;38(4):193–200.

    Article  CAS  PubMed  Google Scholar 

  24. Iverson DA, Ward TG, Blumenkranz MS. Indications and results of relaxing retinotomy. Ophthalmology. 1990;97(10):1298–304.

    Article  CAS  PubMed  Google Scholar 

  25. Eckardt C, Behrendt S, Zwick A. Results of silicone oil removal from eyes treated with retinectomies. Ger J Ophthalmol. 1992;1(1):2–6.

    CAS  PubMed  Google Scholar 

  26. Shalaby KA. Relaxing retinotomies and retinectomies in the management of retinal detachment with severe proliferative vitreoretinopathy (PVR). Clin Ophthalmol. 2010;4:1107–14.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Banaee T, Hosseini SM, Eslampoor A, Abrishami M, Moosavi M. Peripheral 360 degrees retinectomy in complex retinal detachment. Retina (Phila PA). 2009;29(6):811–8.

    Article  Google Scholar 

  28. Lam RF, Cheung BTO, Yuen CYF, Wong D, Lam DSC, Lai WW. Retinal redetachment after silicone oil removal in proliferative vitreoretinopathy: a prognostic factor analysis. Am J Ophthalmol. 2008;145(3):527–33.

    Article  PubMed  Google Scholar 

  29. Halberstadt M, Domig D, Kodjikian L, Koerner F, Garweg JG. PVR recurrence and the timing of silicon oil removal. Klin Monbl Augenheilkd. 2006;223(5):361–6.

    Article  CAS  PubMed  Google Scholar 

  30. Coll GE, Chang S, Sun J, Wieland MR, Berrocal MH. Perfluorocarbon liquid in the management of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1995;102(4):630–8; discussion 638–9.

    Article  CAS  PubMed  Google Scholar 

  31. Blumenkranz MS, Azen SP, Aaberg T, Boone DC, Lewis H, Radtke N, et al. Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy. Silicone Study Report 5. The Silicone Study Group. Am J Ophthalmol. 1993;116(5):557–64.

    Article  CAS  PubMed  Google Scholar 

  32. Lewis H, Burke JM, Abrams GW, Aaberg TM. Perisilicone proliferation after vitrectomy for proliferative vitreoretinopathy. Ophthalmology. 1988;95(5):583–91.

    Article  CAS  PubMed  Google Scholar 

  33. Steel DH, Weir P, James CR. Silicone assisted, argon laser confinement of recurrent proliferative vitreoretinopathy related retinal detachment: a technique to allow silicone oil removal in problem eyes. Br J Ophthalmol. 1997;81(9):765–70.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  34. Cox MS, Azen SP, Barr CC, Linton KL, Diddie KR, Lai MY, et al. Macular pucker after successful surgery for proliferative vitreoretinopathy. Silicone Study Report 8. Ophthalmology. 1995;102(12):1884–91.

    Article  CAS  PubMed  Google Scholar 

  35. Lewis H, Verdaguer JI. Surgical treatment for chronic hypotony and anterior proliferative vitreoretinopathy. Am J Ophthalmol. 1996;122(2):228–35.

    Article  CAS  PubMed  Google Scholar 

  36. Roth DB, Sears JE, Lewis H. Removal of retained subfoveal perfluoro-n-octane liquid. Am J Ophthalmol. 2004;138(2):287–9.

    Article  PubMed  Google Scholar 

  37. Abrams GW, Azen SP, Barr CC, Lai MY, Hutton WL, Trese MT, et al. The incidence of corneal abnormalities in the Silicone Study. Silicone Study Report 7. Arch Ophthalmol. 1995;113(6):764–9.

    Article  CAS  PubMed  Google Scholar 

  38. Chen W, Chen H, Hou P, Fok A, Hu Y, Lam DSC. Midterm results of low-dose intravitreal triamcinolone as adjunctive treatment for proliferative vitreoretinopathy. Retina (Phila PA). 2011;31(6):1137–42.

    Article  CAS  Google Scholar 

  39. Sundaram V, Barsam A, Virgili G. Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database Syst Rev. 2013;1:CD006421.

    PubMed  Google Scholar 

  40. Abrams GW, Azen SP, McCuen 2nd BW, Flynn Jr HW, Lai MY, Ryan SJ. Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone Study report 11. Arch Ophthalmol. 1997;115(3):335–44.

    Article  CAS  PubMed  Google Scholar 

  41. Brown GC, Brown MM, Sharma S, Busbee B, Landy J. A cost-utility analysis of interventions for severe proliferative vitreoretinopathy. Am J Ophthalmol. 2002;133(3):365–72.

    Article  PubMed  Google Scholar 

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García-Arumi, J., Velázquez-Villoria, D. (2015). Management of Proliferative Vitreoretinopathy. In: Patelli, F., Rizzo, S. (eds) Management of Complicated Vitreoretinal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-17208-8_5

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  • DOI: https://doi.org/10.1007/978-3-319-17208-8_5

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17207-1

  • Online ISBN: 978-3-319-17208-8

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