Abstract
Proliferative vitreoretinopathy (PVR) is the clinical syndrome associated with retinal traction and detachment in which cells with proliferative potential multiply and contract on retinal surfaces and in the vitreous compartment. PVR presents with a broad spectrum of severity ranging from subtle retinal wrinkling to a total rigid retinal detachment, retinal shortening, and advanced periretinal proliferation. Although surgical reattachment of retinas associated with PVR can now be achieved in most cases, visual results remain disappointing. Therefore, prevention through early recognition of risk factors and subtle signs of PVR and appropriate modification of standard surgical techniques for retinal detachment remain of great importance.
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References
Glaser BM, Cardin A, Biscoe B. Proliferative vitreoretinopathy. The mechanism of development of vitreoretinal traction. Ophthalmology. 1987;94(4):327–32.
Campochiaro PA. Pathogenic mechanisms in proliferative vitreoretinopathy. Arch Ophthalmol. 1997;115(2):237–41.
Guidry C. The role of Müller cells in fibrocontractive retinal disorders. Prog Retin Eye Res. 2005;24(1):75–86.
Ryan SJ. Retina. 5th ed. Philadelphia: Mosby; 2013.
Hui Y, Shi Y, Zhang X, Yang K, Yu C. TNF-alpha, IL-8 and IL-6 in the early inflammatory stage of experimental PVR model induced by macrophages. Zhonghua Yan Ke Za Zhi. 1999;35(2):140–3.
Charteris DG, Sethi CS, Lewis GP, Fisher SK. Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology. Eye (Lond). 2002;16(4):369–74.
Girard P, Mimoun G, Karpouzas I, Montefiore G. Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery. Retina (Phila PA). 1994;14(5):417–24.
Yanyali A, Bonnet M. Risk factors of postoperative proliferative vitreoretinopathy in giant tears. J Fr Ophtalmol. 1996;19(3):175–80.
Bonnet M, Guenoun S. Surgical risk factors for severe postoperative proliferative vitreoretinopathy (PVR) in retinal detachment with grade B PVR. Graefes Arch Clin Exp Ophthalmol. 1995;233(12):789–91.
The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1983;90(2):121–5.
Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM. An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol. 1991;112(2):159–65.
Aaberg TM. Surgery as the primary management of proliferative vitreoretinopathy: a history reflecting my experiences and biases. Arch Ophthalmol. 2010;128(8):1068–70.
Oyagi T, Emi K. Vitrectomy without scleral buckling for proliferative vitreoretinopathy. Retina (Phila PA). 2004;24(2):215–8.
Joussen AM, Kirchhof B, Schrage N, Ocklenburg C, Hilgers R-D, HSO Study Group. Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO study): design issues and implications. Acta Ophthalmol Scand. 2007;85(6):623–30.
Beekhuis WH, Ando F, Zivojnović R, Mertens DA, Peperkamp E. Basal iridectomy at 6 o’clock in the aphakic eye treated with silicone oil: prevention of keratopathy and secondary glaucoma. Br J Ophthalmol. 1987;71(3):197–200.
Furino C, Micelli Ferrari T, Boscia F, Cardascia N, Recchimurzo N, Sborgia C. Triamcinolone-assisted pars plana vitrectomy for proliferative vitreoretinopathy. Retina (Phila PA). 2003;23(6):771–6.
Jonas JB, Söfker A, Hayler J, Degenring RF. Intravitreal crystalline triamcinolone acetonide as an additional tool in pars plana vitrectomy for complicated proliferative vitreoretinopathy? Acta Ophthalmol Scand. 2003;81(6):663–5.
Feron EJ, Veckeneer M, Parys-Van Ginderdeuren R, Van Lommel A, Melles GRJ, Stalmans P. Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy. Arch Ophthalmol. 2002;120(2):141–4.
Teba FA, Mohr A, Eckardt C, Wong D, Kusaka S, Joondeph BC, et al. Trypan blue staining in vitreoretinal surgery. Ophthalmology. 2003;110(12):2409–12.
García-Arumí J, Corcostegui B, Tallada N. Subretinal membranes in proliferative vitreoretinopathy. An immunohistochemical study. Retina (Phila PA). 1992;12(3 Suppl):S55–9.
Lewis H, Aaberg TM, Abrams GW, McDonald HR, Williams GA, Mieler WF. Subretinal membranes in proliferative vitreoretinopathy. Ophthalmology. 1989;96(9):1403–14; discussion 1414–5.
Richards SC, Maberley AL. Complications of retinotomies for subretinal fluid drainage. Can J Ophthalmol. 1993;28(1):24–7.
Pastor JC, Méndez MC, de la Fuente MA, Coco RM, García-Arumí J, Rodríguez de la Rúa E, et al. Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening. Ophthalmic Res. 2006;38(4):193–200.
Iverson DA, Ward TG, Blumenkranz MS. Indications and results of relaxing retinotomy. Ophthalmology. 1990;97(10):1298–304.
Eckardt C, Behrendt S, Zwick A. Results of silicone oil removal from eyes treated with retinectomies. Ger J Ophthalmol. 1992;1(1):2–6.
Shalaby KA. Relaxing retinotomies and retinectomies in the management of retinal detachment with severe proliferative vitreoretinopathy (PVR). Clin Ophthalmol. 2010;4:1107–14.
Banaee T, Hosseini SM, Eslampoor A, Abrishami M, Moosavi M. Peripheral 360 degrees retinectomy in complex retinal detachment. Retina (Phila PA). 2009;29(6):811–8.
Lam RF, Cheung BTO, Yuen CYF, Wong D, Lam DSC, Lai WW. Retinal redetachment after silicone oil removal in proliferative vitreoretinopathy: a prognostic factor analysis. Am J Ophthalmol. 2008;145(3):527–33.
Halberstadt M, Domig D, Kodjikian L, Koerner F, Garweg JG. PVR recurrence and the timing of silicon oil removal. Klin Monbl Augenheilkd. 2006;223(5):361–6.
Coll GE, Chang S, Sun J, Wieland MR, Berrocal MH. Perfluorocarbon liquid in the management of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1995;102(4):630–8; discussion 638–9.
Blumenkranz MS, Azen SP, Aaberg T, Boone DC, Lewis H, Radtke N, et al. Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy. Silicone Study Report 5. The Silicone Study Group. Am J Ophthalmol. 1993;116(5):557–64.
Lewis H, Burke JM, Abrams GW, Aaberg TM. Perisilicone proliferation after vitrectomy for proliferative vitreoretinopathy. Ophthalmology. 1988;95(5):583–91.
Steel DH, Weir P, James CR. Silicone assisted, argon laser confinement of recurrent proliferative vitreoretinopathy related retinal detachment: a technique to allow silicone oil removal in problem eyes. Br J Ophthalmol. 1997;81(9):765–70.
Cox MS, Azen SP, Barr CC, Linton KL, Diddie KR, Lai MY, et al. Macular pucker after successful surgery for proliferative vitreoretinopathy. Silicone Study Report 8. Ophthalmology. 1995;102(12):1884–91.
Lewis H, Verdaguer JI. Surgical treatment for chronic hypotony and anterior proliferative vitreoretinopathy. Am J Ophthalmol. 1996;122(2):228–35.
Roth DB, Sears JE, Lewis H. Removal of retained subfoveal perfluoro-n-octane liquid. Am J Ophthalmol. 2004;138(2):287–9.
Abrams GW, Azen SP, Barr CC, Lai MY, Hutton WL, Trese MT, et al. The incidence of corneal abnormalities in the Silicone Study. Silicone Study Report 7. Arch Ophthalmol. 1995;113(6):764–9.
Chen W, Chen H, Hou P, Fok A, Hu Y, Lam DSC. Midterm results of low-dose intravitreal triamcinolone as adjunctive treatment for proliferative vitreoretinopathy. Retina (Phila PA). 2011;31(6):1137–42.
Sundaram V, Barsam A, Virgili G. Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database Syst Rev. 2013;1:CD006421.
Abrams GW, Azen SP, McCuen 2nd BW, Flynn Jr HW, Lai MY, Ryan SJ. Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone Study report 11. Arch Ophthalmol. 1997;115(3):335–44.
Brown GC, Brown MM, Sharma S, Busbee B, Landy J. A cost-utility analysis of interventions for severe proliferative vitreoretinopathy. Am J Ophthalmol. 2002;133(3):365–72.
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García-Arumi, J., Velázquez-Villoria, D. (2015). Management of Proliferative Vitreoretinopathy. In: Patelli, F., Rizzo, S. (eds) Management of Complicated Vitreoretinal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-17208-8_5
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DOI: https://doi.org/10.1007/978-3-319-17208-8_5
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