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Should Molecular Cytogenetic Techniques Be Applied to Facilitate Single Embryo Transfer in Egg Donation Cases? Assessment of Frequency and Distribution of Embryo Aneuploidy After Anonymous Donor Oocyte IVF

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Screening the Single Euploid Embryo

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References

  1. Basille C, Frydman R, El Aly A, Hesters L, Fanchin R, Tachdjian G, et al. Preimplantation genetic diagnosis: state of the art. Eur J Obstet Gynecol Reprod Biol. 2009;145(1):9–13.

    Article  CAS  PubMed  Google Scholar 

  2. Baruch S, Kaufman D, Hudson KL. Genetic testing of embryos: practices and perspectives of US in vitro fertilization clinics. Fertil Steril. 2008;89(5):1053–8.

    Article  PubMed  Google Scholar 

  3. Pray L. Embryo screening and the ethics of human genetic engineering. Nat Educ. 2008;1(1):207.

    Google Scholar 

  4. Sills ES, Palermo GD. Preimplantation genetic diagnosis for elective sex selection, the IVF market economy, and the child–another long day’s journey into night? J Assist Reprod Genet. 2002;19(9):433–7.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Pagidas K, Ying Y, Keefe D. Predictive value of preimplantation genetic diagnosis for aneuploidy screening in repeated IVF-ET cycles among women with recurrent implantation failure. J Assist Reprod Genet. 2008;25(2–3):103–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Sills ES, Yang Z, Walsh DJ, Salem SA. Comprehensive genetic assessment of the human embryo: can empiric application of microarray comparative genomic hybridization reduce multiple gestation rate by single fresh blastocyst transfer? Arch Gynecol Obstet. 2012;286(3):755–61.

    Article  CAS  PubMed  Google Scholar 

  7. Harton GL, Munné S, Surrey M, Grifo J, Kaplan B, McCulloh DH, et al. Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization. Fertil Steril. 2013;100(6):1695–703.

    Article  CAS  PubMed  Google Scholar 

  8. Schoolcraft WB, Fragouli E, Stevens J, Munne S, Katz-Jaffe MG, Wells D. Clinical application of comprehensive chromosomal screening at the blastocyst stage. Fertil Steril. 2010;94(5):1700–6.

    Article  PubMed  Google Scholar 

  9. Scott Jr RT, Ferry K, Su J, Tao X, Scott K, Treff NR. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Fertil Steril. 2012;97(4):870–5.

    Article  PubMed  Google Scholar 

  10. Fritz MA, Speroff L. Female infertility. In: Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011. p. 1137–41.

    Google Scholar 

  11. Munné S, Ary J, Zouves C, Escudero T, Barnes F, Cinioglu C, et al. Wide range of chromosome abnormalities in the embryos of young egg donors. Reprod Biomed Online. 2006;12(3):340–6.

    Article  PubMed  Google Scholar 

  12. Walsh AP, Omar AB, Collins GS, Murray GU, Walsh DJ, Salma U, et al. Application of EU tissue and cell directive screening protocols to anonymous oocyte donors in western Ukraine: data from an Irish IVF programme. J Obstet Gynaecol. 2010;30(6):613–6.

    Article  CAS  PubMed  Google Scholar 

  13. Higgins AS, Flanagan JD, Von Wald T, Hansen KA. Preconception cystic fibrosis screening in infertile couples using an expanded carrier screening test. Obstet Gynecol. 2014;123 Suppl 1:97S.

    Article  Google Scholar 

  14. Sills ES, Schattman GL, Veeck LL, Liu HC, Prasad M, Rosenwaks Z. Characteristics of consecutive in vitro fertilization cycles among patients treated with follicle-stimulating hormone (FSH) and human menopausal gonadotropin versus FSH alone. Fertil Steril. 1998;69(5):831–5.

    Article  CAS  PubMed  Google Scholar 

  15. Johnson DS, Gemelos G, Baner J, Ryan A, Cinnioglu C, Banjevic M, et al. Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol. Hum Reprod. 2010;25(4):1066–75.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Rabinowitz M, Sweetkind-Singer J, Banjevic M, Johnson DS, Kijacic D, Petrov D, et al. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals. 2007. U.S. Patent 2007018467A1, 9 August 2007.

    Google Scholar 

  17. Johnson DS, Rabinowitz M, Banjevic M, Singer J, Cinnioglu C, Baner J, et al. Leveraging parental genotypes to increase confidence in genotype calls on single cells. Hum Reprod. 2008;23 Suppl 1:i67.

    Google Scholar 

  18. Johnson DS, Mortazavi A, Myers RM, Wold B. Genome-wide mapping of in vivo protein-DNA interactions. Science. 2007;316(5830):1497–502.

    Article  CAS  PubMed  Google Scholar 

  19. Wu H, Neale MC. Adjusted confidence intervals for a bounded parameter. Behav Genet. 2012;42(6):886–98.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Mulkay M. The embryo research debate: science and the politics of reproduction. Cambridge: Cambridge University Press; 1997. p. 41. 132–3.

    Book  Google Scholar 

  21. Steffann J, Frydman N, Burlet P, Gigarel N, Hesters L, Kerbrat V, et al. Extending preimplantation genetic diagnosis to HLA typing: the French exception. Bull Acad Natl Med. 2011;195(4–5):1015–21.

    PubMed  Google Scholar 

  22. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2(4):280–91.

    Article  CAS  PubMed  Google Scholar 

  23. Shulman A, Frenkel Y, Dor J, Levran D, Shiff E, Maschiach S. The best donor. Hum Reprod. 1999;14(10):2493–6.

    Article  CAS  PubMed  Google Scholar 

  24. Dean NL, Edwards RG. Oocyte donation–implications for fertility treatment in the nineties. Curr Opin Obstet Gynecol. 1994;6(2):160–5.

    Article  CAS  PubMed  Google Scholar 

  25. Sauer MV, Paulson RJ, Lobo RA. Reversing the natural decline in human fertility. An extended clinical trial of oocyte donation to women of advanced reproductive age. JAMA. 1992;268(10):1275–9.

    Article  CAS  PubMed  Google Scholar 

  26. Reh A, Amarosa A, Licciardi F, Krey L, Berkeley AS, Kump L. Evaluating the necessity for universal screening of prospective oocyte donors using enhanced genetic and psychological testing. Hum Reprod. 2010;25(9):2298–304.

    Article  PubMed  Google Scholar 

  27. Katsoff B, Check JH, Mitchell-Williams J. Defective oocytes are not a common cause of unexplained infertility as determined by evaluation of sharing oocytes between infertile donors and recipients. Clin Exp Obstet Gynecol. 2013;40(2):193–5.

    CAS  PubMed  Google Scholar 

  28. Spandorfer SD, Davis OK, Barmat LI, Chung PH, Rosenwaks Z. Relationship between maternal age and aneuploidy in in vitro fertilization pregnancy loss. Fertil Steril. 2004;81(5):1265–9.

    Article  PubMed  Google Scholar 

  29. Lydic ML, Liu JH, Rebar RW, Thomas MA, Cedars MI. Success of donor oocyte in in vitro fertilization-embryo transfer in recipients with and without premature ovarian failure. Fertil Steril. 1996;65(1):98–102.

    CAS  PubMed  Google Scholar 

  30. Kawwass JF, Monsour M, Crawford S, Kissin DM, Session DR, Kulkarni AD, et al. Trends and outcomes for donor oocyte cycles in the United States, 2000–2010. JAMA. 2013;310(22):2426–34.

    PubMed Central  CAS  PubMed  Google Scholar 

  31. Myers ER. Outcomes of donor oocyte cycles in assisted reproduction. JAMA. 2013;310(22):2403–4.

    Article  CAS  PubMed  Google Scholar 

  32. Min JK, Hughes E, Young D, Gysler M, Hemmings R, Cheung AP, et al. Elective single embryo transfer following in vitro fertilization. J Obstet Gynaecol Can. 2010;32(4):363–77.

    PubMed  Google Scholar 

  33. Larsen EC, Christiansen OB, Kolte AM, Macklon N. New insights into mechanisms behind miscarriage. BMC Med. 2013;11:154.

    Article  PubMed Central  PubMed  Google Scholar 

  34. vonKoss Krowchuk H, Moore ML, Richardson L. Using health care records as sources of data for research. J Nurs Meas. 1995;3(1):3–12.

    CAS  PubMed  Google Scholar 

  35. Sills ES, Collins GS, Salem SA, Jones CA, Peck AC. Balancing selected medication costs with total number of daily injections: a preference analysis of GnRH-agonist and antagonist protocols by IVF patients. Reprod Biol Endocrinol. 2012;10:67.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Bronet F, Martínez E, Gaytán M, Liñán A, Cernuda D, Ariza M, et al. Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients. Hum Reprod. 2012;27(7):1922–9.

    Article  CAS  PubMed  Google Scholar 

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Conflict of Interest

The authors declare no conflict.

Note A version of this work appeared in the journal Molecular Cytogenetics 2014;7:68.

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Authors and Affiliations

  1. Center for Advanced Genetics, Reproductive Research Section, 3144 El Camino Real, Suite 106, Carlsbad, CA, 92008, USA

    E Scott Sills

  2. Faculty of Science and Technology, University of Westminster, London, UK

    E Scott Sills

  3. Division of Analytics and Quantitative Research, Rosenblatt Securities Inc., New York, NY, USA

    Xiang Li

  4. HRC Fertility, Newport Beach, CA, USA

    Daniel A. Potter, Jane L. Frederick & Charlotte D. Khoury

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  1. E Scott Sills
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Correspondence to E Scott Sills .

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  1. Center for Advanced Genetics, Reproductive Research Section, Carlsbad, California, USA

    E Scott Sills

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Sills, E.S., Li, X., Potter, D.A., Frederick, J.L., Khoury, C.D. (2015). Should Molecular Cytogenetic Techniques Be Applied to Facilitate Single Embryo Transfer in Egg Donation Cases? Assessment of Frequency and Distribution of Embryo Aneuploidy After Anonymous Donor Oocyte IVF. In: Sills, E. (eds) Screening the Single Euploid Embryo. Springer, Cham. https://doi.org/10.1007/978-3-319-16892-0_16

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  • DOI: https://doi.org/10.1007/978-3-319-16892-0_16

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16891-3

  • Online ISBN: 978-3-319-16892-0

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