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Endocrine Complications of Cancer Therapy

  • Chapter
Survivors of Childhood and Adolescent Cancer

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Endocrinopathy after therapeutic irradiation represents a treatable late effect of successful cancer therapy and highlights the importance of careful follow-up for adults and children. The endocrine effects of irradiation have been extensively studied and demonstrate the systemic manifestations of late effects after localized or large volume irradiation, the differential sensitivity of functional subunits of the hypothalamus and other critical endocrine organs to radiation dose, the low-dose radiation effects in normal tissues, and the benefit of newer radiation methods and modalities.

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Abbreviations

ACTH:

Adrenocorticotropic hormone

ADH:

Antidiuretic hormone

AM:

Morning

AMH:

Anti-Mullerian hormone

BMD:

Bone mineral density

BMI:

Body mass index

CNS:

Central nervous system

CT:

Computed tomography

DXA:

Dual-energy x-ray absorptiometry

FSH:

Follicular-stimulating hormone

GH:

Growth hormone

GHD:

GH deficiency

GHRH:

GH-releasing hormone

GnRH:

Gonadotropin-releasing hormone

Gy:

Gray

HPA:

Hypothalamic-pituitary axis

IGFBP3:

Insulin-like growth factor binding protein

IGF-I:

Insulin-like growth factor

LH:

Luteinizing hormone

MR:

Magnetic resonance

OGTT:

Oral glucose tolerance test

PM:

Afternoon

PRL:

Prolactin

RT:

Radiation therapy

SD:

Standard deviation

T3:

Triiodothyronine

T4:

Thyroxine

TRH:

Thyrotropin-releasing hormone

TSH:

Thyroid-stimulating hormone

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Cincinnati Children’s Hospital Medical Center and University of Cincinnati, 3333 Burnet Avenue, MLC 7012, Cincinnati, OH, 45229, USA

    Susan R. Rose MD & Sarah Lawson

  2. Division of Hematology and Oncology, Cincinnati Children’s Hospital Medical Center and University of Cincinnati, 3333 Burnet Avenue, MLC 7012, Cincinnati, OH, 45229, USA

    Karen Burns

  3. Division of Radiation Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA

    Thomas E. Merchant

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  1. Susan R. Rose MD
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  2. Sarah Lawson
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  3. Karen Burns
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  4. Thomas E. Merchant
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Correspondence to Susan R. Rose MD .

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Editors and Affiliations

  1. Department of Pediatrics, MD Anderson Cancer Center, Houston, Texas, USA

    Cindy L. Schwartz

  2. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Wendy L. Hobbie

  3. Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, James P. Wilmot Cancer Ctr, Rochester, New York, USA

    Louis S. Constine

  4. Center for Cancer And Blood Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA

    Kathleen S. Ruccione

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Rose, S.R., Lawson, S., Burns, K., Merchant, T.E. (2015). Endocrine Complications of Cancer Therapy. In: Schwartz, C., Hobbie, W., Constine, L., Ruccione, K. (eds) Survivors of Childhood and Adolescent Cancer. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-16435-9_5

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  • DOI: https://doi.org/10.1007/978-3-319-16435-9_5

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