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ACP and Amulet: Trials and Registries Results

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Left Atrial Appendage Closure

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Percutaneous left atrial appendage (LAA) closure is considered an alternative to anticoagulation in patients with non valvular atrial fibrilation (NVAF) at risk of stroke or peripheral embolization. Despite the relatively recent introduction of the technique, percutaneous LAA occlusion is growing rapidly in reference centers all over the world. The Amplatzer™ Cardiac Plug (ACP) and Amplatzer™ Amulet are a first- and second-generation device for percutaneous LAA occlusion, respectively. Although no randomized trials are available, a 5-year multicenter experience with the ACP and several published registries have shown a remarkable performance of the device in terms of feasibility and safety as well as efficacy for stroke/peripheral embolism prevention and hemorrhagic risk reduction at long-term follow-up. The Amplatzer Amulet device has been recently released (CE mark since January 2013). Although similar in design, several important modifications have been added to facilitate the implantation process and reduce the number of complications.

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Author information

Authors and Affiliations

  1. Department of Cardiology, Thorax Unit, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

    Xavier Freixa M.D.

  2. Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece

    Apostolos Tzikas M.D., Ph.D.

  3. Medical Intensive Care Unit and Structural Heart Program, Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada

    Réda Ibrahim M.D.

Authors
  1. Xavier Freixa M.D.
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  2. Apostolos Tzikas M.D., Ph.D.
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  3. Réda Ibrahim M.D.
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Corresponding author

Correspondence to Apostolos Tzikas M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada

    Jacqueline Saw

  2. Cardiovascular Intervention Center Research, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Saibal Kar

  3. Scripps Translational Science Institute, Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California, USA

    Matthew J. Price

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© 2016 Springer International Publishing Switzerland

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Freixa, X., Tzikas, A., Ibrahim, R. (2016). ACP and Amulet: Trials and Registries Results. In: Saw, J., Kar, S., Price, M. (eds) Left Atrial Appendage Closure. Contemporary Cardiology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16280-5_13

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  • DOI: https://doi.org/10.1007/978-3-319-16280-5_13

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-16279-9

  • Online ISBN: 978-3-319-16280-5

  • eBook Packages: MedicineMedicine (R0)

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