Skip to main content
SpringerLink
Log in

Corticosteroids in Pediatric Nephrology

  • Chapter
Systemic Corticosteroids for Inflammatory Disorders in Pediatrics

Abstract

Steroid treatment is indispensable and sometimes life-saving in children with some common and uncommon kidney diseases. Higher doses are used than in adult patients, which lead to marked short-term side effects and in many cases quite severe long-term side effects. The aim is always to use as few steroids as possible, with the goal of weaning this treatment as soon as other immunosuppressive drugs start to be effective.

Steroids are used for several indications in pediatric nephrology. The most important are inflammatory kidney diseases, either glomerulonephritis or a vasculitic disease, and idiopathic nephrotic syndrome. They are also used in children receiving a kidney transplant, which is, however, outside of the scope of this book.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Eddy AA, Symons JM (2003) Nephrotic syndrome in childhood. Lancet 362:629–639

    Article  PubMed  Google Scholar 

  2. Arneil GC (1971) The nephrotic syndrome. Pediatr Clin North Am 18:547–559

    CAS  PubMed  Google Scholar 

  3. Hodson EM, Knight JF, Willis NS, Craig JC (2000) Corticosteroid therapy in nephrotic syndrome: a meta-analysis of randomised controlled trials. Arch Dis Child 83:45–51

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Teeninga N, Kist-van Holthe JE, van Rijswijk N et al (2013) Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. J Am Soc Nephrol 24:149–159

    Article  CAS  PubMed  Google Scholar 

  5. Hodson EM, Craig JC (2013) Corticosteroid therapy for steroid-sensitive nephrotic syndrome in children: dose or duration? J Am Soc Nephrol 24:7–9

    Article  CAS  PubMed  Google Scholar 

  6. Alternate-day versus intermittent prednisone in frequently relapsing nephrotic syndrome. A report of “Arbetsgemeinschaft fur Padiatrische Nephrologie” (1979). Lancet 1:401–403

    Google Scholar 

  7. Simmonds J, Grundy N, Trompeter R, Tullus K (2010) Long-term steroid treatment and growth: a study in steroid-dependent nephrotic syndrome. Arch Dis Child 95:146–149

    Article  PubMed  Google Scholar 

  8. Mori K, Honda M, Ikeda M (2004) Efficacy of methylprednisolone pulse therapy in steroid-resistant nephrotic syndrome. Pediatr Nephrol 19:1232–1236

    Article  PubMed  Google Scholar 

  9. Yorgin PD, Krasher J, Al-Uzri AY (2001) Pulse methylprednisolone treatment of idiopathic steroid-resistant nephrotic syndrome. Pediatr Nephrol 16:245–250

    Article  CAS  PubMed  Google Scholar 

  10. Fine RN (2007) Recurrence of nephrotic syndrome/focal segmental glomerulosclerosis following renal transplantation in children. Pediatr Nephrol 22:496–502

    Article  PubMed Central  PubMed  Google Scholar 

  11. Rodriguez-Iturbe B, Musser JM (2008) The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 19:1855–1864

    Article  PubMed  Google Scholar 

  12. Cameron JS (1994) Lupus nephritis in childhood and adolescence. Pediatr Nephrol 8:230–249

    Article  CAS  PubMed  Google Scholar 

  13. Tullus K (2012) New developments in the treatment of systemic lupus erythematosus. Pediatr Nephrol 27:727–732

    Article  PubMed  Google Scholar 

  14. Marks SD, Tullus K (2010) Modern therapeutic strategies for paediatric systemic lupus erythematosus and lupus nephritis. Acta Paediatr 99:967–974

    Article  CAS  PubMed  Google Scholar 

  15. Condon MB, Ashby D, Pepper RJ et al (2013) Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis 72:1280–1286

    Article  CAS  PubMed  Google Scholar 

  16. McCarthy HJ, Tizard EJ (2010) Clinical practice: diagnosis and management of Henoch-Schonlein purpura. Eur J Pediatr 169:643–650

    Article  PubMed  Google Scholar 

  17. Ruperto N, Ozen S, Pistorio A et al (2010) EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation. Ann Rheum Dis 69:790–797

    Article  PubMed  Google Scholar 

  18. Davin JC, Weening JJ (2003) Diagnosis of Henoch-Schonlein purpura: renal or skin biopsy? Pediatr Nephrol 18:1201–1203

    Article  PubMed  Google Scholar 

  19. Dudley J, Smith G, Llewelyn-Edwards A, Bayliss K, Pike K, Tizard J (2013) Randomised, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schonlein Purpura (HSP). Arch Dis Child 98:756–763

    Article  PubMed  Google Scholar 

  20. Mitsioni A (2001) IgA nephropathy in children. Nephrol Dial Transplant 16(Suppl 6):123–125

    Article  PubMed  Google Scholar 

  21. Little MA, Pusey CD (2004) Rapidly progressive glomerulonephritis: current and evolving treatment strategies. J Nephrol 17(Suppl 8):S10–S19

    PubMed  Google Scholar 

  22. Brogan P, Eleftheriou D, Dillon M (2010) Small vessel vasculitis. Pediatr Nephrol 25:1025–1035

    Article  PubMed Central  PubMed  Google Scholar 

  23. Kallenberg CG (2014) The diagnosis and classification of microscopic polyangiitis. J Autoimmun 48–49:90–93

    Article  PubMed  Google Scholar 

  24. Ozen S, Pistorio A, Iusan SM et al (2010) EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis 69:798–806

    Article  PubMed  Google Scholar 

  25. Eleftheriou D, Melo M, Marks SD et al (2009) Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford) 48:978–986

    Article  CAS  Google Scholar 

  26. Eleftheriou D, Dillon MJ, Tullus K et al (2013) Systemic polyarteritis nodosa in the young: a single-center experience over thirty-two years. Arthritis Rheum 65:2476–2485

    Article  CAS  PubMed  Google Scholar 

  27. Ulinski T, Sellier-Leclerc AL, Tudorache E, Bensman A, Aoun B (2012) Acute tubulointerstitial nephritis. Pediatr Nephrol 27:1051–1057

    Article  PubMed  Google Scholar 

  28. Tullus K (2012) What do the latest guidelines tell us about UTIs in children under 2 years of age. Pediatr Nephrol 27:509–511

    Article  PubMed  Google Scholar 

  29. Toffolo A, Ammenti A, Montini G (2012) Long-term clinical consequences of urinary tract infections during childhood: a review. Acta Paediatr 101:1018–1031

    Article  PubMed  Google Scholar 

  30. Huang YY, Chen MJ, Chiu NT, Chou HH, Lin KY, Chiou YY (2011) Adjunctive oral methylprednisolone in pediatric acute pyelonephritis alleviates renal scarring. Pediatrics 128:e496–e504

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nephrology, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK

    Kjell Tullus MD, PhD, FRCPCH

Authors
  1. Kjell Tullus MD, PhD, FRCPCH
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kjell Tullus MD, PhD, FRCPCH .

Editor information

Editors and Affiliations

  1. AOU Meyer Pediatric Rheumatology, Firenze, Italy

    Rolando Cimaz

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Tullus, K. (2015). Corticosteroids in Pediatric Nephrology. In: Cimaz, R. (eds) Systemic Corticosteroids for Inflammatory Disorders in Pediatrics. Adis, Cham. https://doi.org/10.1007/978-3-319-16056-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-16056-6_13

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-16055-9

  • Online ISBN: 978-3-319-16056-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation