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Clinical Pharmacology and the Individualized Approach to Treatment

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Optimizing Treatment for Children in the Developing World

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Abstract

Specific drug therapy has been one of the major advances in child health, but benefits have frequently not been realized for children in the developing world. Challenges for drug therapy for children in LMICs include cost and availability of drugs, gaps in key knowledge on drug efficacy and safety in children, ready access to this information, identification of determinants of drug response that differ in children in various regions, characterization of patterns of adverse drug events, formulation issues and the availability of skilled clinicians, and investigators with expertise on drug therapy in children in LMICs. Clinical pharmacology offers considerable potential for addressing these problems, with approaches such as targeted pharmacoepidemology, development of novel formulations, and targeted training of health care workers. International collaboration and innovations in research and training offer great potential for improved health of children worldwide.

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Author information

Authors and Affiliations

  1. Clinical Investigation Program, Paediatrics, Physiology and Pharmacology and Medicine, Western University and Robarts Research Institute, Western University, London, ON, Canada

    Michael J. Rieder MD, PhD

Authors
  1. Michael J. Rieder MD, PhD
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Correspondence to Michael J. Rieder MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada

    Stuart MacLeod

  2. University of Melbourne Medical School, Melbourne, VIC, Australia

    Suzanne Hill

  3. Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, Canada

    Gideon Koren

  4. Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University, Hostpital Karolinska Institutet, Stockholm, Sweden

    Anders Rane

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Rieder, M.J. (2015). Clinical Pharmacology and the Individualized Approach to Treatment. In: MacLeod, S., Hill, S., Koren, G., Rane, A. (eds) Optimizing Treatment for Children in the Developing World. Adis, Cham. https://doi.org/10.1007/978-3-319-15750-4_17

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  • DOI: https://doi.org/10.1007/978-3-319-15750-4_17

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-15749-8

  • Online ISBN: 978-3-319-15750-4

  • eBook Packages: MedicineMedicine (R0)

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