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Oxidative Stress in Noise-Induced Hearing Loss

  • Chapter
Free Radicals in ENT Pathology

Abstract

In this review, we describe recent investigations on the relationship between oxidative stress and noise-induced hearing loss (NIHL). Mechanisms of NIHL will be discussed in terms of the formation of free radicals and pathways to cell pathology in the inner ear leading to NIHL, the clinically interesting post-exposure continuation of free radical formation and oxidative stress, and the opportunities provided for post-exposure treatment. The role of genetic factors influencing oxidative stress and NIHL is discussed. Finally, we introduce and discuss the “physiological cell signaling function of ROS” and the concept of “programmed necrosis, necroptosis,” and how these factors may dictate new strategies of translational research and provide promise for direct therapeutic treatment of NIHL.

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Authors and Affiliations

  1. Department of Otolaryngology—Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Daisuke Yamashita M.D., Ph.D.

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  1. Daisuke Yamashita M.D., Ph.D.
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Correspondence to Daisuke Yamashita M.D., Ph.D. .

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Editors and Affiliations

  1. Cochlear Signaling & Tissue Engin., University of Michigan Kresge Hearing Research Institute, Ann Arbor, Michigan, USA

    Josef Miller

  2. Dept of Speech , Lang & Hearing Sci, Univ of Florida Health Sciences Center, Gainesville, Florida, USA

    Colleen G. Le Prell

  3. Div . of Otolaryngology Head & Neck Surgery, SIU School of Medicine, Springfield, Illinois, USA

    Leonard Rybak

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© 2015 Springer International Publishing Switzerland

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Yamashita, D. (2015). Oxidative Stress in Noise-Induced Hearing Loss. In: Miller, J., Le Prell, C., Rybak, L. (eds) Free Radicals in ENT Pathology. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-13473-4_8

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