Skip to main content

Generalized Anxiety Disorder

  • Chapter
Anxiety Disorders and Gender

Abstract

Generalized anxiety disorder (GAD) is one of the more prevalent anxiety disorders. However, many questions still remain regarding its etiopathogenesis and optimal treatment, including possible effects of gender. This chapter provides an overview about the prevalence of GAD, its diagnosis, psychological and (neuro-)biological models as well as treatment options, highlighting any gender differences as reported so far. As for most anxiety disorders, gender differences have been most consistently revealed for prevalence, with females being approximately 1.5–2 times as likely as males to meet criteria for GAD. However, the cause for this female preponderance is largely unknown to date. While some first evidence points towards an important role of different emotion regulation strategies in women and men, almost no information is available on possible gender effects on the genetic or neurobiological underpinning of the disorder. With regard to the diagnosis and treatment of GAD, gender appears not to play a major role except for health care utilization.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    http://apps.who.int/classifications/icd11/browse/f/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f1712535455. Entered on March 25, 2014.

References

  • Albano AM, Silverman WK (1996) Guide to the use of the anxiety disorders interview schedule for DSM-IV-child and parent versions. Oxford University Press, London

    Google Scholar 

  • Allgulander C (2012) Generalized anxiety disorder: a review of recent findings. J Exp Clin Med 4(2):88–91

    Google Scholar 

  • Altemus M (2006) Sex differences in depression and anxiety disorders: potential biological determinants. Horm Behav 50(4):534–538

    PubMed  Google Scholar 

  • Alwahhabi F (2003) Anxiety symptoms and generalized anxiety disorder in the elderly: a review. Harv Rev Psychiatry 11(4):180–193

    PubMed  Google Scholar 

  • Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG et al (2010) Npy moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depress Anxiety 27(3):270–275

    PubMed Central  PubMed  Google Scholar 

  • Andlin-Sobocki P, Wittchen HU (2005) Cost of anxiety disorders in Europe. Eur J Neurol 12(Suppl 1):39–44

    PubMed  Google Scholar 

  • Andrews G, Goldberg DP, Krueger RF, Carpenter WT, Hyman SE, Sachdev P et al (2009) Exploring the feasibility of a meta-structure for DSM-V and ICD-11: could it improve utility and validity? Psychol Med 39(12):1993–2000

    CAS  PubMed  Google Scholar 

  • Andrews G, Hobbs MJ, Borkovec TD, Beesdo K, Craske MG, Heimberg RG et al (2010) Generalized worry disorder: a review of DSM-IV generalized anxiety disorder and options for DSM-V. Depress Anxiety 27:134–147

    PubMed  Google Scholar 

  • Angst J, Gamma A, Baldwin DS, Ajdacic-Gross V, Rossler W (2009) The generalized anxiety spectrum: prevalence, onset, course and outcome. Eur Arch Psychiatry Clin Neurosci 259(1):37–45

    PubMed  Google Scholar 

  • APA (2000) Diagnostic and statistical manual of mental disorders, text revision (DSM-IV-TR), 4th edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  • APA (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Google Scholar 

  • Baldwin DS, Anderson IM, Nutt DJ, Bandelow B, Bond A, Davidson JRT et al (2005) Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 19(6):567–596

    CAS  PubMed  Google Scholar 

  • Baldwin D, Woods R, Lawson R, Taylor D (2011) Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis. BMJ 342. doi: http://dx.doi.org/10.1136/bmj.d1199

  • Baldwin DS, Anderson IM, Nutt DJ, Allgulander C, Bandelow B, den Boer JA et al (2014) Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol. doi:10.1177/0269881114525674

    Google Scholar 

  • Bardeen JR, Stevens EN, Murdock KW, Lovejoy MC (2013) A preliminary investigation of sex differences in associations between emotion regulation difficulties and higher-order cognitive abilities. Pers Individual Differences 55(1):70–75

    Google Scholar 

  • Beesdo K (2006) Wie entstehen Generalisierte Ängste? Eine prospektiv-longitudinale, klinisch-epidemiologische Studie bei Jugendlichen und jungen Erwachsenen [The development of generalized anxiety. A prospective-longitudinal, clinicalepidemiologic study among adolescents and young adults]. TUD Press, Dresden

    Google Scholar 

  • Beesdo K, Hoyer J, Jacobi F, Low NCP, Höfler M, Wittchen HU (2009a) Association between generalized anxiety levels and pain in a community sample: evidence for diagnostic specificity. J Anxiety Disord 23:684–693

    PubMed  Google Scholar 

  • Beesdo K, Knappe S, Pine DS (2009b) Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatr Clin North Am 32(3):483–524

    PubMed Central  PubMed  Google Scholar 

  • Beesdo K, Jacobi F, Hoyer J, Low NCP, Höfler M, Wittchen HU (2010a) Pain associated with specific anxiety and depressive disorders in a nationally representative population sample. Soc Psychiatry Psychiatr Epidemiol 45(1):89–104

    PubMed  Google Scholar 

  • Beesdo K, Pine DS, Lieb R, Wittchen HU (2010b) Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Arch Gen Psychiatry 67(1):47–57

    PubMed  Google Scholar 

  • Beesdo-Baum K, Knappe S (2012) Developmental epidemiology of anxiety disorders. Child Adolesc Psychiatr Clin N Am 21(3):457–478

    PubMed  Google Scholar 

  • Beesdo-Baum K, Winkel S, Pine DS, Hoyer J, Höfler M, Lieb R et al (2011) The diagnostic threshold of generalized anxiety disorder in the community: a developmental perspective. J Psychiatr Res 45:962–972

    PubMed  Google Scholar 

  • Beesdo-Baum K, Jenjahn E, Hofler M, Lueken U, Becker ES, Hoyer J (2012a) Avoidance, safety behavior, and reassurance seeking in generalized anxiety disorder. Depress Anxiety 29(11):948–957

    PubMed  Google Scholar 

  • Beesdo-Baum K, Klotsche J, Knappe S, Craske MG, LeBeau RT, Hoyer J et al (2012b) Psychometric properties of the dimensional anxiety scales for DSM-5 in an unselected sample of German treatment seeking patients. Depress Anxiety 29:1014–1024

    PubMed  Google Scholar 

  • Behar E, Zuellig AR, Borkovec TD (2005) Thought and imaginal activity during worry and trauma recall. Behav Ther 36(2):157–168

    Google Scholar 

  • Behar E, DiMarco ID, Hekler EB, Mohlman J, Staples AM (2009) Current theoretical models of generalized anxiety disorder (GAD): conceptual review and treatment implications. J Anxiety Disord 23(8):1011–1023

    PubMed  Google Scholar 

  • Bener A, Al-Kazaz M, Ftouni D, Al-Harthy M, Dafeeah EE (2013) Diagnostic overlap of depressive, anxiety, stress and somatoform disorders in primary care. Asia-Pac Psychiatry 5(1):E29–E38

    PubMed  Google Scholar 

  • Berger A, Dukes E, Wittchen HU, Morlock R, Edelsberg J, Oster G (2009a) Patterns of healthcare utilization in patients with generalized anxiety disorder in general practice in Germany. Eur J Psychiatry 23(2):90–100

    Google Scholar 

  • Berger A, Mychaskiw M, Dukes E, Edelsberg J, Oster G (2009b) Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorder. BMC Geriatr 9:31

    PubMed Central  PubMed  Google Scholar 

  • Berger A, Edelsberg J, Bollu V, Alvir JM, Dugar A, Joshi AV et al (2011) Healthcare utilization and costs in patients beginning pharmacotherapy for generalized anxiety disorder: a retrospective cohort study. BMC Psychiatry 11:193

    PubMed Central  CAS  PubMed  Google Scholar 

  • Birmaher B, Khetarpal S, Brent D, Cully M, Balach L, Kaufman J et al (1997) The screen for child anxiety related emotional disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry 36(4):545–553

    CAS  PubMed  Google Scholar 

  • Bjelland I, Dahl AA, Haug TT, Neckelmann D (2002) The validity of the hospital anxiety and depression scale – an updated literature review. J Psychosom Res 52(2):69–77

    PubMed  Google Scholar 

  • Bobes J, Caballero L, Vilardaga I, Rejas J (2011) Disability and health-related quality of life in outpatients with generalised anxiety disorder treated in psychiatric clinics: is there still room for improvement? Ann Gen Psychiatry 10:7

    PubMed Central  PubMed  Google Scholar 

  • Borkovec TD (1994) The nature, functions, and origins of worry. In: Davey G, Tallis F (eds) Worrying: perspectives on theory assessment and treatment. Wiley & Sons, Sussex, pp 5–33

    Google Scholar 

  • Borkovec TD, Inz J (1990) The nature of worry in generalized anxiety disorder – a predominance of thought activity. Behav Res Ther 28(2):153–158

    CAS  PubMed  Google Scholar 

  • Borkovec TD, Roemer L (1995) Perceived functions of worry among generalized anxiety disorder subjects – distraction from more emotionally distressing topics. J Behav Ther Exp Psychiatry 26(1):25–30

    CAS  PubMed  Google Scholar 

  • Borkovec TD, Alcaine OM, Behar E (2004) Avoidance theory of worry and generalized anxiety disorder. In: Heimberg R, Turk C, Mennin D (eds) Generalized anxiety disorder: advances in research and practice. Guilford Press, New York, pp 77–108

    Google Scholar 

  • Boswell JF, Thompson-Hollands J, Farchione TJ, Barlow DH (2013) Intolerance of uncertainty: a common factor in the treatment of emotional disorders. J Clin Psychol 69(6):630–645

    PubMed  Google Scholar 

  • Brewerton TD, Lydiard RB, Johnson MR, Ballenger JC, Fossey MD, Zealberg JJ et al (1995) CSF serotonin: diagnostic and seasonal differences. Biol Psychiatry 37(9):655–655

    Google Scholar 

  • Brown TA, Barlow DH (2002) Classification of anxiety and mood disorders. In: Barlow DH (ed) Anxiety and its disorders, 2nd edn. Guilford Press, New York, pp 292–329

    Google Scholar 

  • Brown TA, Naragon-Gainey K (2013) Evaluation of the unique and specific contributions of dimensions of the triple vulnerability model to the prediction of DSM-IV anxiety and mood disorder constructs. Behav Ther 44(2):277–292

    PubMed Central  PubMed  Google Scholar 

  • Brown TA, Antony MM, Barlow DH (1992) Psychometric properties of the penn state worry questionnaire in a clinical anxiety disorders sample. Behav Res Ther 30(1):33–37

    CAS  PubMed  Google Scholar 

  • Burstein M, Beesdo-Baum K, He J-P, Merikangas KR (2013) Threshold and subthreshold generalized anxiety disorder among US adolescents: prevalence, sociodemographic and clinical characteristics. Psychol Med. doi:10.1017/S0033291713002997

    Google Scholar 

  • Bystritsky A, Hovav S, Sherbourne C, Stein MB, Rose RD, Campbell-Sills L et al (2012) Use of complementary and alternative medicine in a large sample of anxiety patients. Psychosomatics 53(3):266–272

    PubMed Central  PubMed  Google Scholar 

  • Carleton RN (2012) The intolerance of uncertainty construct in the context of anxiety disorders: theoretical and practical perspectives. Expert Rev Neurother 12(8):937–947

    CAS  PubMed  Google Scholar 

  • Carter RM, Wittchen H-U, Pfister H, Kessler RC (2001) One-year prevalence of subthreshold and threshold DSM-IV generalized anxiety disorder in a nationally representative sample. Depress Anxiety 13:78–88

    CAS  PubMed  Google Scholar 

  • Cassidy J, Lichtenstein-Phelps J, Sibrava NJ, Thomas CL Jr, Borkovec TD (2009) Generalized anxiety disorder: connections with self-reported attachment. Behav Ther 40(1):23–38

    PubMed  Google Scholar 

  • Cerda M, Sagdeo A, Johnson J, Galea S (2010) Genetic and environmental influences on psychiatric comorbidity: a systematic review. J Affect Disord 126(1–2):14–38

    PubMed Central  CAS  PubMed  Google Scholar 

  • Chessick CA, Allen MH, Thase ME, Batista Miralha da Cunha AABC, Kapczinski FFK, Silva de Lima M, dos Santos Souza JJSS (2006) Azapirones for generalized anxiety disorder. Cochrane Database Syst Rev (3):CD006115

    Google Scholar 

  • Connor KM, Davidson JR (1998) Generalized anxiety disorder: neurobiological and pharmacotherapeutic perspectives. Biol Psychiatry 44(12):1286–1294

    CAS  PubMed  Google Scholar 

  • Copeland WE, Angold A, Shanahan L, Costello EJ (2014) Longitudinal patterns of anxiety from childhood to adulthood: the great smoky mountains study. J Am Acad Child Adolesc Psychiatry 53(1):21–33

    PubMed Central  PubMed  Google Scholar 

  • Cougle JR, Fitch KE, Fincham FD, Riccardi CJ, Keough ME, Timpano KR (2012) Excessive reassurance seeking and anxiety pathology: tests of incremental associations and directionality. J Anxiety Disord 26(1):117–125

    PubMed  Google Scholar 

  • Crits-Christoph P, Newman MG, Rickels K, Gallop R, Gibbons MBC, Hamilton JL et al (2011) Combined medication and cognitive therapy for generalized anxiety disorder. J Anxiety Disord 25(8):1087–1094

    PubMed Central  PubMed  Google Scholar 

  • Cuijpers P, Sijbrandij M, Koole S, Huibers M, Berking M, Andersson G (2014) Psychological treatment of generalized anxiety disorder: a meta-analysis. Clin Psychol Rev 34(2):130–140

    PubMed  Google Scholar 

  • de Graaf R, Bijl R, Spijker J, Beekman ATF, Vollebergh WAM (2003) Temporal sequencing of lifetime mood disorders in relation to comorbid anxiety and substance use disorders. Soc Psychiatry Psychiatr Epidemiol 38:1–11

    PubMed  Google Scholar 

  • Di Nardo PA, Brown TA, Barlow DH (1994) Anxiety disorders interview schedule for DSM-IV: lifetime version (ADIS-IV-L). Psychological Corporation, San Antonio

    Google Scholar 

  • Dickson KS, Ciesla JA, Reilly LC (2012) Rumination, worry, cognitive avoidance, and behavioral avoidance: examination of temporal effects. Behav Ther 43(3):629–640

    PubMed  Google Scholar 

  • Dugas MJ, Gagnon F, Ladouceur R, Freeston MH (1998) Generalized anxiety disorder: a preliminary test of a conceptual model. Behav Res Ther 36(2):215–226

    CAS  PubMed  Google Scholar 

  • Durham RC (2004) Treatment of generalized anxiety disorder. Psychiatry 3(4):30–34

    Google Scholar 

  • Etkin A, Schatzberg AF (2011) Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. Am J Psychiatry 168(9):968–978

    PubMed  Google Scholar 

  • Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD (2009) Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 66(12):1361–1372

    PubMed  Google Scholar 

  • Faravelli C, Abrardi L, Bartolozzi D, Cecchi C, Cosci F, D’Adamo D et al (2004) The Sesto Fiorentino Study: background, methods and preliminary results. Psychother Psychosom 73:216–225

    PubMed  Google Scholar 

  • Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C et al (2001) Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry 25(5):965–982

    CAS  PubMed  Google Scholar 

  • First M, Spitzer R, Gibbon M, Williams J (1997) Structured clinical interview for DSM-IV. American Psychiatric Press, Washington, DC

    Google Scholar 

  • Francis JL, Moitra E, Dyck I, Keller MB (2012) The impact of stressful life events on relapse of generalized anxiety disorder. Depress Anxiety 29(5):386–391

    PubMed Central  PubMed  Google Scholar 

  • Gamez W, Watson D, Doebbeling BN (2007) Abnormal personality and the mood and anxiety disorders: implications for structural models of anxiety and depression. J Anxiety Disord 21(4):526–539

    PubMed  Google Scholar 

  • Giddens JL, Xian H, Scherrer JF, Eisen SA, Potenza MN (2011) Shared genetic contributions to anxiety disorders and pathological gambling in a male population. J Affect Disord 132(3):406–412

    PubMed Central  PubMed  Google Scholar 

  • Goncalves DC, Byrne GJ (2012) Sooner or Later: Age at Onset of Generalized Anxiety Disorder in Older Adults. Depress Anxiety 29(1):39–46

    PubMed  Google Scholar 

  • Grant BF, Hasin DS, Stinson FS, Dawson DA, Ruan WJ, Goldstein RB et al (2005) Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on alcohol and related conditions. Psychol Med 35(12):1747–1759

    PubMed  Google Scholar 

  • Greenberg PE, Sisitsky T, Kessler RC, Finkelstein SN, Berndt ER, Davidson JR et al (1999) The economic burden of anxiety disorders in the 1990s. J Clin Psychiatry 60(7):427–435

    CAS  PubMed  Google Scholar 

  • Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E et al (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10):718–779

    CAS  PubMed  Google Scholar 

  • Hamilton M (1959) The assessment of anxiety-states by rating. Br J Med Psychol 32(1):50–55

    CAS  PubMed  Google Scholar 

  • Hernandez E, Lastra S, Urbina M, Carreira I, Lima L (2002) Serotonin, 5-hydroxyindoleacetic acid and serotonin transporter in blood peripheral lymphocytes of patients with generalized anxiety disorder. Int Immunopharmacol 2(7):893–900

    CAS  PubMed  Google Scholar 

  • Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158(10):1568–1578

    CAS  PubMed  Google Scholar 

  • Hettema JM, Prescott CA, Myers JM, Neale MC, Kendler KS (2005) The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 62(2):182–189

    PubMed  Google Scholar 

  • Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS (2006) A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163(5):857–864

    PubMed  Google Scholar 

  • Hilbert K, Lueken U, Beesdo-Baum K (2014) Neural structures, functioning and connectivity in generalized anxiety disorder and interaction with neuroendocrine systems: a systematic review. J Affect Disord 158:114–126

    PubMed  Google Scholar 

  • Hildebrandt MG, Steyerberg EW, Stage KB, Passchier J, Kragh-Soerensen P (2003) Are gender differences important for the clinical effects of antidepressants? Am J Psychiatry 160(9):1643–1650

    PubMed  Google Scholar 

  • Hoffman D, Dukes E, Wittchen H-U (2008) Human and economic burden of generalized anxiety disorder. Depress Anxiety 25(1):72–90

    PubMed  Google Scholar 

  • Hopko DR, Bourland SL, Stanley MA, Beck JG, Novy DM, Averill PM et al (2000) Generalized anxiety disorder in older adults: examining the relation between clinician severity ratings and patient self-report measures. Depress Anxiety 12(4):217–225

    CAS  PubMed  Google Scholar 

  • Hoyer J, Beesdo K (2006) Generalisierte Angststörung [Generalised anxiety disorder]. In: Wittchen HU, Hoyer J (eds) Klinische Psychologie und Psychotherapie [Clinical psychology and psychotherapy]. Springer Medizin Verlag, Heidelberg

    Google Scholar 

  • Hoyer J, Beesdo-Baum K (2011) Generalisierte Angststörung. [Generalized anxiety disorder]. In: Wittchen HU, Hoyer J (eds) Klinische Psychologie und Psychotherapie. [Textbook of clinical psychology and psychotherapy], 2nd edn. Springer, Heidelberg, pp 937–952

    Google Scholar 

  • Hoyer J, Beesdo-Baum K (2012) Prolonged imaginal exposure based on worry scenarios. In: Neudeck P, Wittchen H-U (eds) Exposure therapy: rethinking the model – refining the method. Springer, New York, pp 245–260

    Google Scholar 

  • Hoyer J, Gloster AT (2009) Psychotherapy for generalized anxiety disorder: don’t worry, it works! Psychiatr Clin North Am 32:629–640

    PubMed  Google Scholar 

  • Hoyer J, Becker E, Margraf J (2002) Generalized anxiety disorder and clinical worry episodes in young women. Psychol Med 32:1227–1237

    CAS  PubMed  Google Scholar 

  • Hoyer J, Beesdo K, Gloster AT, Höfler M, Runge J, Becker ES (2009) Worry exposure versus applied relaxation in the treatment of generalized anxiety disorder. Psychother Psychosom 78:106–115

    PubMed  Google Scholar 

  • Hunot V, Churchill R, Silva de Lima M, Teixeira V (2007) Psychological therapies for generalised anxiety disorder. Cochrane Database Syst Rev (1):CD001848. doi:10.1002/14651858.CD001848.pub4

  • Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980–988

    CAS  PubMed  Google Scholar 

  • Keers R, Aitchison KJ (2010) Gender differences in antidepressant drug response. Int Rev Psychiatry 22(5):485–500

    PubMed  Google Scholar 

  • Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA (2003) Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 60(8):789–796

    PubMed  Google Scholar 

  • Kendler KS, Myers JM, Maes HH, Keyes CLM (2011) The relationship between the genetic and environmental influences on common internalizing psychiatric disorders and mental well-being. Behav Genet 41(5):641–650

    PubMed Central  PubMed  Google Scholar 

  • Kessler RC, Ustun TB (2004) The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res 13(2):93–121

    PubMed  Google Scholar 

  • Kessler RC, Andrade L, Bijl R, Offord D, Demler O, Stein DJ (2002a) The effects of co-morbidity on the onset and persistence of generalized anxiety disorder in the ICPE surveys. Psychol Med 32:1213–1225

    CAS  PubMed  Google Scholar 

  • Kessler RC, Berglund PA, Dewit DJ, Ustun TB, Wang PS, Wittchen HU (2002b) Distinguishing generalized anxiety disorder from major depression: prevalence and impairment from current pure and comorbid disorders in the US and Ontario. Int J Methods Psychiatr Res 11(3):99–111

    PubMed  Google Scholar 

  • Kessler RC, Brandenburg N, Lane M, Roy-Byrne P, Stang PD, Stein DJ et al (2005a) Rethinking the duration requirement for generalized anxiety disorder: evidence from the National Comorbidity Survey Replication. Psychol Med 35(7):1073–1082

    PubMed  Google Scholar 

  • Kessler RC, Chiu WT, Demler O, Walters EE (2005b) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617–627

    PubMed Central  PubMed  Google Scholar 

  • Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU (2012) Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res 21(3):169–184

    PubMed Central  PubMed  Google Scholar 

  • Knappe S, Klotsche J, Strobel A, LeBeau RT, Craske MG, Wittchen H-U et al (2013) Dimensional anxiety scales for DSM-5: sensitivity to clinical severity. Eur Psychiatry 28:448–456

    CAS  PubMed  Google Scholar 

  • Knappe S, Klotsche J, Heyde F, Hiob S, Hoyer J, Strobel A et al (2014) Test-retest reliability and sensitivity to change of the dimensional anxiety scales for DSM-5. CNS Spectr 19(3):256–267. doi:10.1017/S1092852913000710

    PubMed  Google Scholar 

  • Kogan JN, Edelstein BA, McKee DR (2000) Assessment of anxiety in older adults: current status. J Anxiety Disord 14(2):109–132

    CAS  PubMed  Google Scholar 

  • Kornstein SG, Schatzberg AF, Thase ME, Yonkers KA, McCullough JP, Keitner GI et al (2000) Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 157(9):1445–1452

    CAS  PubMed  Google Scholar 

  • Kroenke K, Spitzer RL, Williams JBW, Monahan PO, Löwe B (2007) Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med 146:317–325

    PubMed  Google Scholar 

  • LeBeau RT, Glenn DE, Hanover LN, Beesdo-Baum K, Wittchen H-U, Craske MG (2012) A dimensional approach to measuring anxiety for DSM-5. Int J Methods Psychiatr Res 21(4):258–272

    PubMed  Google Scholar 

  • Lee S, Tsang A, Ruscio AM, Haro JM, Stein DJ, Alonso J et al (2009) Implications of modifying the duration requirement of generalized anxiety disorder in developed and developing countries. Psychol Med 39(7):1163–1176

    PubMed Central  CAS  PubMed  Google Scholar 

  • Legerstee JS, Garnefski N, Verhulst FC, Utens EM (2011) Cognitive coping in anxiety-disordered adolescents. J Adolesc 34(2):319–326

    PubMed  Google Scholar 

  • Lieb R, Becker E, Altamura C (2005) The epidemiology of generalized anxiety disorder in Europe. Eur Neuropsychopharmacol 15(4):445–452

    CAS  PubMed  Google Scholar 

  • Llera SJ, Newman MG (2014) Rethinking the role of worry in generalized anxiety disorder: evidence supporting a model of emotional contrast avoidance. Behav Ther 45(3):283–299

    PubMed  Google Scholar 

  • Maack DJ, Tull MT, Gratz KL (2012) Examining the incremental contribution of behavioral inhibition to generalized anxiety disorder relative to other axis I disorders and cognitive-emotional vulnerabilities. J Anxiety Disord 26(6):689–695

    PubMed  Google Scholar 

  • Macefield VG (2009) Developments in autonomic research: a review of the latest literature. Clin Auton Res 19(4):193–196

    PubMed  Google Scholar 

  • Manassis K, Avery D, Butalia S, Mendlowitz S (2004) Cognitive-behavioral therapy with childhood anxiety disorders: functioning in adolescence. Depress Anxiety 19(4):209–216

    PubMed  Google Scholar 

  • Marganska A, Gallagher M, Miranda R (2013) Adult attachment, emotion dysregulation, and symptoms of depression and generalized anxiety disorder. Am J Orthopsychiatry 83(1):131–141

    PubMed  Google Scholar 

  • Marks DM, Park MH, Ham BJ, Han C, Patkar AA, Masand PS et al (2008) Paroxetine: safety and tolerability issues. Expert Opin Drug Saf 7(6):783–794

    Google Scholar 

  • Martenyi F, Dossenbach M, Mraz K, Metcalfe S (2001) Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients: a double-blind trial of antidepressants with serotonergic or norepinephrinergic reuptake inhibition profile. Eur Neuropsychopharmacol 11(3):227–232

    CAS  PubMed  Google Scholar 

  • McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ et al (2007) Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry 64(1):97–106

    PubMed  Google Scholar 

  • McLaughlin KA, Mennin DS, Farach FJ (2007) The contributory role of worry in emotion generation and dysregulation in generalized anxiety disorder. Behav Res Ther 45(8):1735–1752

    PubMed  Google Scholar 

  • McLean CP, Anderson ER (2009) Brave men and timid women? A review of the gender differences in fear and anxiety. Clin Psychol Rev 29(6):496–505

    PubMed  Google Scholar 

  • McLean CP, Asnaani A, Litz BT, Hofmann SG (2011) Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 45(8):1027–1035

    PubMed Central  PubMed  Google Scholar 

  • Melchior M, Caspi A, Milne BJ, Danese A, Poulton R, Moffitt TE (2007) Work stress precipitates depression and anxiety in young, working women and men. Psychol Med 37(8):1119–1129

    PubMed Central  PubMed  Google Scholar 

  • Meng XF, Kou CG, Shi JP, Yu YQ, Huang YQ (2011) Susceptibility genes, social environmental risk factors and their interactions in internalizing disorders among mainland Chinese undergraduates. J Affect Disord 132(1–2):254–259

    PubMed  Google Scholar 

  • Mennin DS, Heimberg RG, Turk CL, Fresco DM (2002) Applying an emotion regulation framework to integrative approaches to generalized anxiety disorder. Clin Psychol Sci Pract 9(1):85–90

    Google Scholar 

  • Mennin DS, Heimberg RG, Turk CL, Fresco DM (2005) Preliminary evidence for an emotion dysregulation model of generalized anxiety disorder. Behav Res Ther 43(10):1281–1310

    PubMed  Google Scholar 

  • Mennin DS, Holaway RM, Fresco DM, Moore MT, Heimberg RG (2007) Delineating components of emotion and its dysregulation in anxiety and mood psychopathology. Behav Ther 38(3):284–302

    PubMed  Google Scholar 

  • Mennin DS, McLaughlin KA, Flanagan TJ (2009) Emotion regulation deficits in generalized anxiety disorder, social anxiety disorder, and their co-occurrence. J Anxiety Disord 23(7):866–871

    PubMed Central  PubMed  Google Scholar 

  • Meyer TJ, Miller ML, Metzger RL, Borkovec TD (1990) Development and validation of the Penn State Worry Questionnaire. Behav Res Ther 28(6):487–495

    CAS  PubMed  Google Scholar 

  • Mitte K (2005) Meta-analysis of cognitive-behavioral treatments for generalized anxiety disorder: a comparison with pharmacotherapy. Psychol Bull 131(5):785–795

    PubMed  Google Scholar 

  • Moffitt TE, Caspi A, Harrington H, Milne BJ, Melchior M, Goldberg D et al (2007) Generalized anxiety disorder and depression: childhood risk factors in a birth cohort followed to age 32. Psychol Med 37(3):441–452

    PubMed  Google Scholar 

  • Montgomery S, Chatamra K, Pauer L, Whalen E, Baldinetti F (2008) Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder. Br J Psychiatry 193(5):389–394

    PubMed  Google Scholar 

  • Munk-Jorgenson P, Allgulander C, Dahl AA, Foldager L, Holm M, Rasmussen I et al (2006) Prevalence of generalized anxiety disorder in general practice in Denmark, Finland, Norway and Sweden. Psychiatr Serv 57(12):1738–1744

    Google Scholar 

  • Newman MG, Zuellig AR, Kachin KE, Constantino MJ, Przeworski A, Erickson T et al (2002) Preliminary reliability and validity of the generalized anxiety disorder questionnaire – IV: a revised self-report diagnostic measure of generalized anxiety disorder. Behav Ther 33(2):215–233

    Google Scholar 

  • Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ et al (2009) Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 166(3):302–310

    PubMed Central  PubMed  Google Scholar 

  • Nolen-Hoeksema S (2012) Emotion regulation and psychopathology: the role of gender. Annu Rev Clin Psychol 8:161–187

    PubMed  Google Scholar 

  • Olatunji BO, Moretz MW, Zlomke KR (2010) Linking cognitive avoidance and GAD symptoms: the mediating role of fear of emotion. Behav Res Ther 48(5):435–441

    PubMed  Google Scholar 

  • Öst L-G (1987) Applied relaxation: description of a coping technique and review of controlled studies. Behav Res Ther 25:397–409

    PubMed  Google Scholar 

  • Park YM, Lee SH, Kim S, Bae SM (2010) The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 34(2):313–316

    PubMed  Google Scholar 

  • Parker G, Hadzi-Pavlovic D (2004) Is the female preponderance in major depression secondary to a gender difference in specific anxiety disorders? Psychol Med 34(3):461–470

    CAS  PubMed  Google Scholar 

  • Payne S, Bolton D, Perrin S (2011) A pilot investigation of cognitive therapy for generalized anxiety disorder in children aged 7–17 years. Cogn Ther Res 35(2):171–178

    Google Scholar 

  • Pollack MH, Meoni P, Otto MW, Simon N, Hackett D (2003) Predictors of outcome following venlafaxine extended-release treatment of DSM-IV generalized anxiety disorder: a pooled analysis of short- and long-term studies. J Clin Psychopharmacol 23(3):250–259

    CAS  PubMed  Google Scholar 

  • Price RB, Mohlman J (2007) Inhibitory control and symptom severity in late life generalized anxiety disorder. Behav Res Ther 45(11):2628–2639

    PubMed  Google Scholar 

  • Price RB, Eldreth DA, Mohlman J (2011) Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation. Transl Psychiatry 1:e46

    PubMed Central  CAS  PubMed  Google Scholar 

  • Read KL, Comer JS, Kendall PC (2013) The intolerance of uncertainty scale for children (IUSC): discriminating principal anxiety diagnoses and severity. Psychol Assess 25(3):722–729

    PubMed  Google Scholar 

  • Rettew DC, Doyle AC, Kwan M, Stanger C, Hudziak JJ (2006) Exploring the boundary between temperament and generalized anxiety disorder: a receiver operating characteristic analysis. J Anxiety Disord 20(7):931–945

    PubMed Central  PubMed  Google Scholar 

  • Rickels K, Rynn M (2001) Overview and clinical presentation of generalized anxiety disorder. Psychiatr Clin North Am 24(1):1–17

    CAS  PubMed  Google Scholar 

  • Robichaud M, Dugas MJ, Conway M (2003) Gender differences in worry and associated cognitive-behavioral variables. J Anxiety Disord 17(5):501–516

    PubMed  Google Scholar 

  • Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J et al (1988) The composite international diagnostic interview – an epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45(12):1069–1077

    CAS  PubMed  Google Scholar 

  • Rodriguez BF, Weisberg RB, Pagano ME, Bruce SE, Spencer MA, Culpepper L et al (2006) Characteristics and predictors of full and partial recovery from generalized anxiety disorder in primary care patients. J Nerv Ment Dis 194(2):91–97

    PubMed Central  PubMed  Google Scholar 

  • Roemer L, Molina S, Litz BT, Borkovec TD (1996) Preliminary investigation of the role of previous exposure to potentially traumatizing events in generalized anxiety disorder. Depress Anxiety 4(3):134–138

    PubMed  Google Scholar 

  • Roemer L, Orsillo SM, Salters-Pedneault K (2008) Efficacy of an acceptance-based behavior therapy for generalized anxiety disorder: evaluation in a randomized controlled trial. J Consult Clin Psychol 76(6):1083–1089

    PubMed Central  PubMed  Google Scholar 

  • Roemer L, Lee JK, Salters-Pedneault K, Erisman SM, Orsillo SM, Mennin DS (2009) Mindfulness and emotion regulation difficulties in generalized anxiety disorder: preliminary evidence for independent and overlapping contributions. Behav Ther 40(2):142–154

    PubMed Central  PubMed  Google Scholar 

  • Rubio G, Lopez-Ibor JJ (2007) Generalized anxiety disorder: a 40-year follow-up study. Acta Psychiatr Scand 115(5):372–379

    CAS  PubMed  Google Scholar 

  • Safren SA, Gershuny BS, Marzol P, Otto MW, Pollack MH (2002) History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder. J Nerv Ment Dis 190(7):453–456

    PubMed  Google Scholar 

  • Salters-Pedneault K, Roemer L, Tull MT, Rucker L, Mennin DS (2006) Evidence of broad deficits in emotion regulation associated with chronic worry and generalized anxiety disorder. Cogn Ther Res 30(4):469–480

    Google Scholar 

  • Samochowiec J, Hajduk A, Samochowiec A, Horodnicki J, Stepien G, Grzywacz A et al (2004) Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Res 128(1):21–26

    CAS  PubMed  Google Scholar 

  • Sareen J, Cox BJ, Clara I, Asmundson GJG (2005) The relationship between anxiety disorders and physical disorders in the U.S. national comorbidity survey. Depress Anxiety 21:193–202

    PubMed  Google Scholar 

  • Schonfeld WH, Verboncoeur CJ, Fifer SK, Lipschutz RC, Lubeck DP, Buesching DP (1997) The functioning and well-being of patients with unrecognized anxiety disorders and major depressive disorder. J Affect Disord 43(2):105–119

    CAS  PubMed  Google Scholar 

  • Shear M, Vander Bilt J, Rucci P, Endicott J, Lydiard B, Otto M et al (2001) Reliability and validity of a Structured Interview Guide for the Hamilton Anxiety Rating Scale (SIGH-A). Depress Anxiety 13(4):166–178

    CAS  PubMed  Google Scholar 

  • Shear K, Belnap BH, Mazumdar S, Houck P, Rollman BL (2006) Generalized anxiety disorder severity scale (GADSS): a preliminary validation study. Depress Anxiety 23:77–82

    PubMed  Google Scholar 

  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33, quiz 34–57

    PubMed  Google Scholar 

  • Shin LM, Liberzon I (2010) The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35(1):169–191

    PubMed Central  PubMed  Google Scholar 

  • Simon NM, Zalta AK, Worthington JJ, Hoge EA, Christian KM, Stevens JC et al (2006) Preliminary support for gender differences in response to fluoxetine for generalized anxiety disorder. Depress Anxiety 23(6):373–376

    CAS  PubMed  Google Scholar 

  • Sipila T, Kananen L, Greco D, Donner J, Silander K, Terwilliger JD et al (2010) An association analysis of circadian genes in anxiety disorders. Biol Psychiatry 67(12):1163–1170

    PubMed  Google Scholar 

  • Spitzer RL, Kroenke K, Williams JBW, Lowe B (2006) A brief measure for assessing generalized anxiety disorder – the GAD-7. Arch Intern Med 166(10):1092–1097

    PubMed  Google Scholar 

  • Stapinski LA, Abbott MJ, Rapee RM (2010) Evaluating the cognitive avoidance model of generalised anxiety disorder: impact of worry on threat appraisal, perceived control and anxious arousal. Behav Res Ther 48(10):1032–1040

    PubMed  Google Scholar 

  • Starcevic V, Portman ME, Beck AT (2012) Generalized anxiety disorder between neglect and an epidemic. J Nerv Ment Dis 200(8):664–667

    PubMed  Google Scholar 

  • Stein DJ (2013) Generalised anxiety disorder. S Afr J Psychiatry 19(3):175–179

    Google Scholar 

  • Stein MB, Heimberg RG (2004) Well-being and life satisfaction in generalized anxiety disorder: comparison to major depressive disorder in a community sample. J Affect Disord 79(1–3):161–166

    PubMed  Google Scholar 

  • Stein DJ, Baldwin DS, Baldinetti F, Mandel F (2008) Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies. Eur Neuropsychopharmacol 18(6):422–430

    CAS  PubMed  Google Scholar 

  • Steiner M, Allgulander C, Ravindran A, Kosar H, Burt T, Austin C (2005) Gender differences in clinical presentation and response to sertraline treatment of generalized anxiety disorder. Hum Psychopharmacol Clin Exp 20(1):3–13

    CAS  Google Scholar 

  • Steudte S, Stalder T, Dettenborn L, Klumbies E, Foley P, Beesdo-Baum K et al (2011) Decreased hair cortisol concentrations in generalised anxiety disorder. Psychiatry Res 186(2–3):310–314

    CAS  PubMed  Google Scholar 

  • Strawn JR, Bitter SM, Weber WA, Chu WJ, Whitsel RM, Adler C et al (2012) Neurocircuitry of generalized anxiety disorder in adolescents: a pilot functional neuroimaging and functional connectivity study. Depress Anxiety 29(11):939–947

    PubMed  Google Scholar 

  • Tadic A, Rujescu D, Szegedi A, Giegling I, Singer P, Moller HJ et al (2003) Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. Am J Med Genet B Neuropsychiatr Genet 117B(1):1–6

    CAS  PubMed  Google Scholar 

  • Tafet GE, Idoyaga-Vargas VP, Abulafia DP, Calandria JM, Roffman SS, Chiovetta A et al (2001) Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci 1(4):388–393

    CAS  PubMed  Google Scholar 

  • Thayer JF, Lane RD (2000) A model of neurovisceral integration in emotion regulation and dysregulation. J Affect Disord 61(3):201–216

    CAS  PubMed  Google Scholar 

  • Tromp DP, Grupe DW, Oathes DJ, McFarlin DR, Hernandez PJ, Kral TR et al (2012) Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Arch Gen Psychiatry 69(9):925–934

    PubMed Central  PubMed  Google Scholar 

  • Tull MT, Stipelman BA, Salters-Pedneault K, Gratz KL (2009) An examination of recent non-clinical panic attacks, panic disorder, anxiety sensitivity, and emotion regulation difficulties in the prediction of generalized anxiety disorder in an analogue sample. J Anxiety Disord 23(2):275–282

    PubMed  Google Scholar 

  • van Eijck FEAM, Branje SJT, Hale WW, Meeus WHJ (2012) Longitudinal associations between perceived parent-adolescent attachment relationship quality and generalized anxiety disorder symptoms in adolescence. J Abnorm Child Psychol 40(6):871–883

    PubMed Central  PubMed  Google Scholar 

  • Vesga-Lopez O, Schneier FR, Wang S, Heimberg RG, Liu SM, Hasin DS et al (2008) Gender differences in generalized anxiety disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry 69(10):1606–1616

    PubMed  Google Scholar 

  • Walkup JT, Albano AM, Piacentini J, Birmaher B, Compton SN, Sherrill JT et al (2008) Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med 359(26):2753–2766

    PubMed Central  CAS  PubMed  Google Scholar 

  • Wang PS, Lane M, Olfson M, Pincus HA, Wells KB, Kessler RC (2005) Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:629–640

    PubMed  Google Scholar 

  • Wetherell JL, Birchler GD, Ramsdell J, Unutzer J (2007) Screening for generalized anxiety disorder in geriatric primary care patients. Int J Geriatr Psychiatry 22(2):115–123

    PubMed  Google Scholar 

  • WHO (1990) Composite International Diagnostic Interview (CIDI). World Health Organization, Geneva

    Google Scholar 

  • WHO (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. World Health Organization, Geneva

    Google Scholar 

  • Wittchen HU (2002) Generalized anxiety disorder: prevalence, burden, and cost to society. Depress Anxiety 16(4):162–171

    PubMed  Google Scholar 

  • Wittchen H-U, Lieb R, Pfister H, Schuster P (2000) The waxing and waning of mental disorders: evaluating the stability of syndromes of mental disorders in the population. Compr Psychiatry 41(2 suppl 1):122–132

    CAS  PubMed  Google Scholar 

  • Wittchen HU, Kessler RC, Beesdo K, Krause P, Hofler M, Hoyer J (2002) Generalized anxiety and depression in primary care: prevalence, recognition, and management. J Clin Psychiatry 63(Suppl 8):24–34

    PubMed  Google Scholar 

  • Wittchen HU, Jacobi F, Rehm J, Gustavsson C, Svensson M, Jönsson B et al (2011) The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21:655–679

    CAS  PubMed  Google Scholar 

  • Wittchen H-U, Härtling S, Dukes E, Morlock R, Edelsberg J, Oster G et al (2012) Generalisierte Angststörung in der primärärztlichen Versorgung: Eine Analyse administrativ-epidemiologischer Daten zu Inanspruchnahme und Versorgungsmerkmalen [Generalised anxiety disorder in primary care: an analysis of administrative and epidemiological data on health-care utilisation and characteristics of patient-centered care]. MMW Fortschr Med 154(3):77–84

    PubMed  Google Scholar 

  • Yonkers KA, Bruce SE, Dyck IR, Keller MB (2003) Chronicity, relapse, and illness–course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up. Depress Anxiety 17(3):173–179

    PubMed  Google Scholar 

  • You JS, Hu SY, Chen B, Zhang HG (2005) Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. Psychiatr Genet 15(1):7–11

    PubMed  Google Scholar 

  • Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67(6):361–370

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Katja Beesdo-Baum .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Beesdo-Baum, K., Hilbert, K. (2015). Generalized Anxiety Disorder. In: Stein, D., Vythilingum, B. (eds) Anxiety Disorders and Gender. Springer, Cham. https://doi.org/10.1007/978-3-319-13060-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-13060-6_1

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13059-0

  • Online ISBN: 978-3-319-13060-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics