Abstract
There is currently an urgent need to develop sustainable and therapeutically relevant advanced drug delivery systems to treat the prevalence of ongoing human diseases and ailments. The effectiveness of such system will depend primarily on the properties and characteristics of the carrier material. In this chapter, marine materials are investigated as potential drug delivery carriers for bone tissue engineering and in the treatment of osteoporosis. This chapter will explore the unique structures of marine materials that set it apart from its synthetic counterparts and the conversion to biocompatible calcium phosphates combined with synthetic modifications, and case studies will demonstrate the potential clinical applications.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26(27):5474–5491
Bruckner A (2002) Life-saving products from coral reefs. Issues Sci Technol 18(3):35
Demers C, Hamdy CR, Corsi K, Chellat F, Tabrizian M, Yahia L (2002) Natural coral exoskeleton as a bone graft substitute: a review. Biomed Mater Eng 12(1):15–35
Patat JL, Guillemin G (1989) Natural coral used as a replacement biomaterial in bone grafts. Ann Chir Plast Esthet 34(3):221–225
Roy DM, Linnehan SK (1974) Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange. Nature 247(5438):220–222
Chou J, Hao J, Hatoyama H, Ben-Nissan B, Milthorpe B, Otsuka M (2013) The therapeutic effect on bone mineral formation from biomimetic zinc containing tricalcium phosphate (ZnTCP) in zinc-deficient osteoporotic mice. PLoS One 8(8):e71821
Chou J, Ito T, Bishop D, Otsuka M, Ben-Nissan B, Milthorpe B (2013) Controlled release of simvastatin from biomimetic beta-TCP drug delivery system. PLoS One 8(1):e54676
Chou J, Ben-Nissan B, Green DW, Valenzuela SM, Kohan L (2011) Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand. Adv Eng Mater 13(1–2):93–99
Sashiwa H, Saimoto H, Shigemasa Y, Ogawa R, Tokura S (1990) Lysozyme susceptibility of partially deacetylated chitin. Int J Biol Macromol 12(5):295–296
Shigemasa Y, Saito K, Sashiwa H, Saimoto H (1994) Enzymatic degradation of chitins and partially deacetylated chitins. Int J Biol Macromol 16(1):43–49
Chou J, Hao J, Hatoyama H, Ben-Nissan B, Milthorpe B, Otsuka M (2015) Effect of biomimetic zinc-containing tricalcium phosphate (Zn-TCP) on the growth and osteogenic differentiation of mesenchymal stem cells. J Tissue Eng Regen Med 9(7):852–858
Chou J, Valenzuela SM, Santos J, Bishop D, Milthorpe B, Green DW, Otsuka M, Ben-Nissan B (2014) Strontium- and magnesium-enriched biomimetic beta-TCP macrospheres with potential for bone tissue morphogenesis. J Tissue Eng Regen Med 8(10):771–778
Chou J, Valenzuela S, Green DW, Kohan L, Milthorpe B, Otsuka M et al (2014) Antibiotic delivery potential of nano- and micro-porous marine structure-derived beta-tricalcium phosphate spheres for medical applications. Nanomedicine (Lond) 9(8):1131–1139
Nyan M, Sato D, Oda M, Machida T, Kobayashi H, Nakamura T et al (2007) Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci 104(4):384–386
Kishi S, Yamaguchi M (1994) Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow cultures. Biochem Pharmacol 48(6):1225–1230
Yamaguchi M, Oishi H, Suketa Y (1987) Stimulatory effect of zinc on bone formation in tissue culture. Biochem Pharmacol 36(22):4007–4012
Ishikawa K, Miyamoto Y, Yuasa T, Ito A, Nagayama M, Suzuki K (2002) Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells. Biomaterials 23(2):423–428
Yamada Y, Ito A, Kojima H, Sakane M, Miyakawa S, Uemura T et al (2008) Inhibitory effect of Zn2+ in zinc-containing beta-tricalcium phosphate on resorbing activity of mature osteoclasts. J Biomed Mater Res A 84(2):344–352
Luo X, Barbieri D, Davison N, Yan Y, de Bruijn JD, Yuan H (2014) Zinc in calcium phosphate mediates bone induction: in vitro and in vivo model. Acta Biomater 10(1):477–485
Otsuka M, Marunaka S, Matsuda Y, Ito A, Naito H, Ichinose N et al (2003) Effect of particle size on zinc release from zinc containing tricalcium phosphate (ZnTCP) in Zn-deficient osteoporosis rats. Biomed Mater Eng 13(2):103–113
Otsuka M, Ohshita Y, Marunaka S, Matsuda Y, Ito A, Ichinose N et al (2004) Effect of controlled zinc release on bone mineral density from injectable Zn-containing beta-tricalcium phosphate suspension in zinc-deficient diseased rats. J Biomed Mater Res A 69(3):552–560
Otsuka M, Oshinbe A, Legeros RZ, Tokudome Y, Ito A, Otsuka K et al (2008) Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats. J Pharm Sci 97(1):421–432
Kannan S, Goetz-Neunhoeffer F, Neubauer J, Ferreira JMF (2011) Cosubstitution of zinc and strontium in β-tricalcium phosphate: synthesis and characterization. J Am Chem Soc 94(1):230–235
Sogo Y, Sakurai T, Onuma K, Ito A (2002) The most appropriate (Ca + Zn)/P molar ratio to minimize the zinc content of ZnTCP/HAP ceramic used in the promotion of bone formation. J Biomed Mater Res 62(3):457–463
Tokudome Y, Ito A, Otsuka M (2011) Effect of zinc-containing beta-tricalcium phosphate nano particles injection on jawbone mineral density and mechanical strength of osteoporosis model rats. Biol Pharm Bull 34(8):1215–1218
Kawamura H, Ito A, Miyakawa S, Layrolle P, Ojima K, Ichinose N et al (2000) Stimulatory effect of zinc-releasing calcium phosphate implant on bone formation in rabbit femora. J Biomed Mater Res 50(2):184–190
Yamaguchi M (2010) Role of nutritional zinc in the prevention of osteoporosis. Mol Cell Biochem 338(1–2):241–254
Ito A, Kawamura H, Miyakawa S, Layrolle P, Kanzaki N, Treboux G et al (2002) Resorbability and solubility of zinc-containing tricalcium phosphate. J Biomed Mater Res 60(2):224–231
Lu H, Kawazoe N, Tateishi T, Chen G, Jin X, Chang J (2010) In vitro proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells cultured with hardystonite (Ca2ZnSi 2O7) and {beta}-TCP ceramics. J Biomater Appl 25(1):39–56
Stein GS, Lian JB (1993) Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14(4):424–442
Marom R, Shur I, Solomon R, Benayahu D (2005) Characterization of adhesion and differentiation markers of osteogenic marrow stromal cells. J Cell Physiol 202(1):41–48
Pina S, Vieira SI, Rego P, Torres PM, da Cruz e Silva OA, da Cruz e Silva EF et al (2010) Biological responses of brushite-forming Zn- and ZnSr- substituted beta-tricalcium phosphate bone cements. Eur Cell Mater 20:162–177
Dan H, Vaquette C, Fisher AG, Hamlet SM, Xiao Y, Hutmacher DW et al (2014) The influence of cellular source on periodontal regeneration using calcium phosphate coated polycaprolactone scaffold supported cell sheets. Biomaterials 35(1):113–122
Vaquette C, Fan W, Xiao Y, Hamlet S, Hutmacher DW, Ivanovski S (2012) A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex. Biomaterials 33(22):5560–5573
Li Y, Ma T, Kniss DA, Lasky LC, Yang ST (2001) Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices. Biotechnol Prog 17(5):935–944
Kitagawa T, Yamaoka T, Iwase R, Murakami A (2006) Three-dimensional cell seeding and growth in radial-flow perfusion bioreactor for in vitro tissue reconstruction. Biotechnol Bioeng 93(5):947–954
van den Dolder J, Bancroft GN, Sikavitsas VI, Spauwen PH, Jansen JA, Mikos AG (2003) Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh. J Biomed Mater Res A 64(2):235–241
Dunkelman NS, Zimber MP, Lebaron RG, Pavelec R, Kwan M, Purchio AF (1995) Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system. Biotechnol Bioeng 46(4):299–305
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this entry
Cite this entry
Chou, J., Hao, J. (2016). Marine Biomaterials as Drug Delivery System for Osteoporosis and Bone Tissue Regeneration. In: Antoniac, I. (eds) Handbook of Bioceramics and Biocomposites. Springer, Cham. https://doi.org/10.1007/978-3-319-12460-5_57
Download citation
DOI: https://doi.org/10.1007/978-3-319-12460-5_57
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12459-9
Online ISBN: 978-3-319-12460-5
eBook Packages: Chemistry and Materials ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics