Abstract
During the last two decades, biomimetics has provided mankind new directions for the utilization of natural organic and inorganic skeletons for novel drug delivery systems and new medical treatment approaches with unique designs ranging from the macro- to the nanoscale. The use of ready-made organic and inorganic marine skeletons has potentially created an opportunity of presenting one of the simplest cures to fundamental issues hampering the future development of regenerative medicine, dentistry, and orthopedics such as providing a richness of framework designs and devices and abundant and available sources of osteopromotive analogues and biomineralization proteins. Organic matrix and inorganic marine skeletons possess a habitat ideal for the proliferation of added mesenchymal stem cell populations and promoting clinically acceptable bone formation. It has been proven that self-sustaining musculoskeletal tissues can be supported by coral and marine sponge skeletons, and bone mineralization can be promoted by the extracts of spongin collagen and nacre seashell organic matrices. This idea is reinforced by the fact that bone morphogenetic protein molecules are produced by endodermal cells into the developing skeleton. Furthermore, the regenerative signaling proteins in bone therapeutics such as TGF and Wnt are also present in early marine sponge development and instrumental to the activation of stem cells in cnidarians. This chapter aims to give a brief background into the nature, morphology, and application of some of these structures in bone grafts, drug delivery, tissue engineering, and specific extracts such as proteins for regenerative medicine.
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References
Ben-Nissan B, Green DW (2013) Marine materials in drug delivery and tissue engineering: from natural role models, to bone regeneration and repair and slow delivery of therapeutic drugs, proteins and genes. In: Kim S-K (ed) Marine biomaterials. Taylor and Francis/CSR Books, Boca Raton, pp 575–602
Green DW, Li G, Milthrope B, Ben-Nissan B (2012) Adult stem cell coatings using biomaterials for regenerative medicine. Mater Today 15:61–68
Ben-Nissan B (2003) Natural bioceramic: from coral to bone and beyond. Curr Opin Solid State Mater Sci 7:283–288
Mann S (1983) Mineralization in biological systems. Struct Bond 54:125
Gonzalez-McQuire R, Green D, Walsh D et al (2005) Fabrication of hydroxyapatite sponges by dextran sulfate/amino acid templating. Biomaterials 26:6652–6656
Green D, Walsh D, Yang X et al (2004) Stimulation of human bone marrow stromal cells using growth factor-encapsulated calcium carbonate porous microspheres. J Mater Chem 14:2206–2212
Walsh D, Mann S (1996) Feigning nature’s sculptures. Chem Br 32:31–34
Walsh D, Boanini E, Tanaka J et al (2005) Synthesis of tri-calcium phosphate sponges by interfacial deposition and thermal transformation of self-supporting inorganic films. J Mater Chem 15:1043–1048
Hall SR, Swinerd VM, Newby FN et al (2006) Fabrication of porous titania (brookite) microparticles with complex morphology by sol-gel replication of pollen grains. Chem Mater 18:598–600
Green DW (2004) Bio-inspired ceramic structures: from invertebrate marine skeletons to biomimetic crystal engineering. J Aust Ceram Soc 40:1–7
Ben-Nissan B, Choi AH (2006) Sol-gel production of bioactive nanocoatings for medical applications. Part I: an introduction. Nanomedicine 1:311–319
Parker AR, Martini N (2006) Structural color in animals-simple to complex optics. Opt Laser Technol 38:315–322
Ben-Nissan B, Green DW (2014) Marine structures as templates for biomaterials. In: Ben-Nissan B (ed) Advances in calcium phosphate biomaterials, Springer series in biomaterials science and engineering (SSBSE). Springer, Berlin, pp 391–414
Mock T, Samanta MP, Iverson V et al (2008) Whole-genome expression profiling of the marine diatom Thalassiosira pseudonana identifies genes involved in silicon bioprocesses. Proc Natl Acad Sci U S A 105:1579–1584
Belegratis MR, Schmidt V, Nees D et al (2014) Diatom-inspired templates for 3D replication: natural diatoms versus laser written artificial diatoms. Bioinspir Biomim 9:016004
Kim ES (2008) Directed evolution: a historical exploration into an evolutionary experimental system of nanobiotechnology, 1965–2006. Minerva 46:463–484
Sia SK, Gillette BM, Yang GJ (2007) Synthetic tissue biology: tissue engineering meets synthetic biology. Birth Defects Res C Embryo Today 81:354–361
LeGeros RZ (1993) Biodegradation and bioresorption of calcium phosphate ceramics. Clin Mater 4:65–88
LeGeros RZ, Gatti AM, Kijkowska R et al (2004) Magnesium tricalcium phosphate: formation and properties. Key Eng Mater 254–256:127–130
Ando J (1958) Tricalcium phosphate and its variation. Bull Chem Soc Jpn 31:196–201
Roy DM, Linnehan S (1974) Hydroxyapatite formed from coral skeleton carbonate by hydrothermal exchange. Nature 247:220–222
Rocha JHG, Lemos AF, Agathopoulos S et al (2005) Scaffolds for bone restoration from cuttlefish. Bone 37:850–857
Martina M, Subramanyam G, Weaver JC et al (2005) Developing macroporous bicontinuous materials as scaffolds for tissue engineering. Biomaterials 26:5609–5616
Townley HE, Parker AR, White-Cooper H (2008) Exploitation of diatom frustules for nanotechnology: tethering active biomolecules. Adv Funct Mater 18:369–374
Boute N, Exposito JY, Boury-Esnault N et al (1996) Type IV collagen in sponges, the missing link in basement membrane ubiquity. Biol Cell 88:37–44
Exposito JY, Cluzel C, Garrone R et al (2002) Evolution of collagens. Anat Rec 268:302–316
Swatschek D, Schatton W, Kellermann J et al (2002) Marine sponge collagen: isolation, characterization and effects on the skin parameters surface pH, moisture and sebum. Eur J Pharm Biopharm 53:107–113
Nicklas M, Schatton W, Heinemann S et al (2009) Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17b-estradiol-hemihydrate. Drug Dev Ind Pharm 35:1035–1042
Aizenberg J, Weaver JC, Thanawala MS et al (2005) Skeleton of Euplectella sp structural hierarchy from the nanoscale to the macroscale. Science 309:275–278
Miserez A, Weaver JC, Thurner PJ et al (2008) Effects of laminate architecture on fracture resistance of sponge biosilica: lessons from nature. Adv Funct Mater 18:1241–1248
Abramovitch-Gottlib L, Geresh S, Vago R (2006) Biofabricated marine hydrozoan: a bioactive crystalline material promoting ossification of mesenchymal stem cells. Tissue Eng 12:729–739
Vago R, Plotquin D, Bunin A et al (2002) Hard tissue remodeling using biofabricated coralline biomaterials. J Biochem Biophys Methods 50:253–259
Lopez E, Vidal B, Berland S et al (1992) Demonstration of the capacity of nacre to induce bone formation by human osteoblasts maintained in vitro. Tissue Cell 24:667–679
Lamghari M, Berland S, Laurent A et al (2001) Bone reactions to nacre injected percutaneously into the vertebrae of sheep. Biomaterials 22:555–562
Lamghari M, Antonietti P, Berland S et al (2001) Arthrodesis of lumbar spine transverse processes using nacre in rabbit. J Bone Miner Res 16:2232–2237
Rousseau M, Lucilia PM, Almeida MJ et al (2003) The water-soluble matrix fraction from the nacre of Pinctada maxima produces earlier mineralization of MC3T3-E1 mouse pre-osteoblasts. Comp Biochem Physiol B 135:1–7
Duplat D, Chabadel A, Gallet M et al (2007) The in vitro osteoclastic degradation of nacre. Biomaterials 28:2155–2162
Westbroek P, Marin F (1998) A marriage of bone and nacre. Nature 392:861–862
Almeida MJ, Pereira L, Milet C et al (2001) Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts. J Biomed Mater Res 57:306–312
Rousseau M, Boulzaguet H, Biagianti J et al (2007) Low molecular weight molecules of oyster nacre induce mineralization of the MC3T3-E1. J Biomed Mater Res A 85:487–497
Zhang C, Li S, Ma Z et al (2006) A novel matrix protein p10 from the nacre of pearl oyster (Pinctada fucata) and its effects on both CaCO3 crystal formation and mineralogic cells. Marine Biotechnol 8:624–633
Liao H, Mutvei H, Hammarstrom L et al (2002) Tissue responses to nacreous implants in rat femur: an in situ hybridization and histochemical study. Biomaterials 23:2693–2701
Kim YM, Kim JJ, Kim YH et al (2000) Effects of organic matrix proteins on the interfacial structures at the bone-biocompatible nacre interface in vitro. Biomaterials 23:2089–2096
Shen Y, Zhu J, Zhang H et al (2006) In vitro osteogenic activity of pearl. Biomaterials 27:281–287
Green DW, Padula MP, Santos J et al (2013) A therapeutic potential for marine skeletal proteins in bone regeneration. Mar Drugs 11:1203–1220
Vago R (2008) Beyond the skeleton. Cnidarian biomaterials as bioactive extracellular microenvironments for tissue engineering. Organogenesis 4:18–22
Stanley G (2003) The evolution of modern corals and their early history. Earth Sci Rev 60:195–225
Bonnelye E, Chabadel A, Saltel F et al (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42:129–138
LeGeros R (1981) Apatites in biological systems. Prog Cryst Growth Charact Mater 41:1–45
Papacharalambous S, Anastasoff K (1993) Natural coral skeleton used as onlay graft for contour augmentation of the face. A preliminary report. Int J Oral Maxillofac Surg 22:260–264
Leupold J, Barfield W, An Y et al (2006) A comparison of ProOsteon, DBX, and collagraft in a rabbit model. J Biomed Mater Res B Appl Biomater 79:292–297
Ehrlich H, Etnoyer P, Litvinov SD et al (2006) Biomaterial structure in deep-sea bamboo coral (Anthozoa: Gorgonacea: Isidiae): perspectives for the development of bone implants and templates for tissue engineering. Mater Werkst 37:552–557
Chou J, Valenzuela SM, Green DW et al (2014) Antibiotic delivery potential of nano and micro porous marine structures derived β-TCP spheres for medical applications. Nanomedicine 9:1131–1138
Bose S, Tarafder S (2012) Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review. Acta Biomater 8:1401–1421
Nurcombe V, Cool SM (2007) Heparan sulfate control of proliferation and differentiation in the stem cell niche. Crit Rev Eukaryot Gene Expr 17:159–171
Rowley JA, Madlambayan G, Mooney DJ (1999) Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20:45–53
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Choi, A.H., Cazalbou, S., Ben-Nissan, B. (2016). Biomimetics and Marine Materials in Drug Delivery and Tissue Engineering. In: Antoniac, I. (eds) Handbook of Bioceramics and Biocomposites. Springer, Cham. https://doi.org/10.1007/978-3-319-12460-5_26
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DOI: https://doi.org/10.1007/978-3-319-12460-5_26
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