Abstract
In this chapter, we will discuss the two enzymes known to synthesize triacylglycerol (or triglyceride, TG) and their role in murine skin and fur physiology. However, it is imperative to note that these enzymes were named based on the initial discovery that they possessed the ability to synthesize TG. Moreover, it is likely that the additional enzymatic activities of one of the enzymes play more important roles in regulating lipid homeostasis in the skin than its ability to synthesize TG.
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References
Bazzano G, et al. Effect of retinoids on follicular cells. J Invest Dermatol. 1993;101:138–42.
Cases S, et al. Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998;95:13018–23.
Cases S, et al. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001;276:38870–6.
Cases S, et al. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 2004;131:3047–55.
Cheng JB, Russell DW. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. J Biol Chem. 2004;279:37798–807.
Chen HC, Smith SJ, Tow B, Elias PM, Farese RV Jr. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest. 2002a;109:175–81.
Chen HC, et al. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002b;109:1049–55.
Cheng D, et al. Identification of acyl coenzyme A: monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. J Biol Chem. 2003;278:13611–4.
Coleman RA, Lewin TM, van Horn CG, Gonzalez-Baró MR. Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?. J Nutr. 2002;132:2123–6.
Flowers MT, et al. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PloS ONE. 2011;6:e19734.
Frank S, Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest. 2000;106:501–9.
Guo Y, Cordes KR, Farese RV Jr, Walther TC. Lipid droplets at a glance. J Cell Sci. 2009;122:749–52.
Kayden HJ, Senior JR, Mattson FH. The monoglyceride pathway of fat absorption in man. J Clin Invest. 1967;46:1695–703.
Kennedy EP. Metabolism of lipides. Ann Rev Biochem. 1957;26:119–48.
Miyazaki M, Dobrzyn A, Elias PM, Ntambi JM. Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci U S A. 2005;102:12501–6.
Morton GJ, Schwartz MW. Leptin and the central nervous system control of glucose metabolism. Physiol Rev. 2011;91:389–411.
Ntambi JM, Miyazaki M. Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol. 2003;14:255–61.
Poeggeler B, et al. Leptin and the skin: a new frontier. Exp Dermatol. 2010;19:12–8.
Shih MY, et al. Retinol esterification by DGAT1 is eessential for retinoid homeostasis in murine skin. J Biol Chem. 2009;284:4292–9.
Smith S, et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000;25:87–90.
Stone SJ, et al. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol chem. 2004;279:11767–76.
Strauss JS, Stewart ME, Downing DT. The effect of 13-cis-retinoic acid on sebaceous glands. Arch Dermatol. 1987;123:1538a-41.
Streeper R, Salomonis N, Cases S, Grueter C. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany). 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292902/.
Turkish AR, et al. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. J Biol Chem. 2005;280:14755–64.
Walther TC, Farese RV Jr. The life of lipid droplets. Biochim Biophys Acta. 2009;1791:459–66.
Weiss SB, Kennedy EP Kiyasu JY. The enzymatic synthesis of triglycerides. J Biol Chem. 1960;235:40–4.
Yen C, Farese R. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003;278;18532–7.
Yen CE, Stone SJ, Cases S, Zhou P, Farese RV Jr. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A. 2002;99:8512–7.
Yen CE, Monetti M, Burri BJ, Farese RV Jr. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J Lipid Res. 2005a;46:1502–11.
Yen CE 4th, Brown CH, Monetti M, Farese RV Jr. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res. 2005b;46:2388–97.
Yen CE, Stone SJ, Koliwad S, Harris C, Farese RV Jr. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008;49:2283–301.
Zouboulis CC, et al. Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. J Invest Dermatol. 1991;96:792–7.
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Grueter, C. (2015). Triglyceride Synthesis Enzymes in Skin/Fur. In: Pappas, A. (eds) Lipids and Skin Health. Springer, Cham. https://doi.org/10.1007/978-3-319-09943-9_16
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DOI: https://doi.org/10.1007/978-3-319-09943-9_16
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