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Endocrine Disorders and Erectile Dysfunction

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Erectile Dysfunction in Hypertension and Cardiovascular Disease

Abstract

Endocrine disorders (except diabetes mellitus) represent an infrequent cause of erectile dysfunction. However, identification of an endocrine disorder in these patients is essential for three major reasons. First, it provides an opportunity for etiologic management of erectile dysfunction instead of symptomatic. Second, endocrine disorders associated with erectile dysfunction might also have important adverse sequelae on the general health and should therefore be timely identified and managed. Third, a limited panel of hormonal tests (i.e., serum total testosterone, thyrotropin, and prolactin levels) is frequently sufficient for reaching a diagnosis of these endocrine disorders. In the present chapter, the endocrine disorders most frequently associated with erectile dysfunction are discussed, with emphasis on their prevalence in patients with erectile dysfunction, the diagnostic work-up, and the effects of their management on erectile function.

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References

  1. Araujo AB, Esche GR, Kupelian V, O’Donnell AB, Travison TG, Williams RE, Clark RV, McKinlay JB (2007) Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab 92:4241–4247

    Article  CAS  PubMed  Google Scholar 

  2. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Baltimore Longitudinal Study of Aging (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 86:724–731

    Article  CAS  PubMed  Google Scholar 

  3. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB (2002) Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 87:589–598

    Article  CAS  PubMed  Google Scholar 

  4. Korenman SG, Morley JE, Mooradian AD, Davis SS, Kaiser FE, Silver AJ, Viosca SP, Garza D (1990) Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab 71:963–969

    Article  CAS  PubMed  Google Scholar 

  5. Rhoden EL, Telöken C, Sogari PR, Souto CA (2002) The relationship of serum testosterone to erectile function in normal aging men. J Urol 167:1745–1748

    Article  CAS  PubMed  Google Scholar 

  6. Shamloul R, Ghanem H (2013) Erectile dysfunction. Lancet 381:153–165

    Article  CAS  PubMed  Google Scholar 

  7. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM, Task Force, Endocrine Society (2010) Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95:2536–2559

    Article  CAS  PubMed  Google Scholar 

  8. Buvat J, Maggi M, Gooren L, Guay AT, Kaufman J, Morgentaler A, Schulman C, Tan HM, Torres LO, Yassin A, Zitzmann M (2010) Endocrine aspects of male sexual dysfunctions. J Sex Med 7:1627–1656

    Article  PubMed  Google Scholar 

  9. Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E, European Association of Urology (2010) Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol 57:804–814

    Article  PubMed  Google Scholar 

  10. Buvat J, Lemaire A (1997) Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy. J Urol 158:1764–1767

    Article  CAS  PubMed  Google Scholar 

  11. McVary KT (2007) Clinical practice. Erectile dysfunction. N Engl J Med 357:2472–2481

    Article  CAS  PubMed  Google Scholar 

  12. Brambilla DJ, O’Donnell AB, Matsumoto AM, McKinlay JB (2007) Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men. Clin Endocrinol Oxf 67:853–862

    Article  CAS  PubMed  Google Scholar 

  13. Citron JT, Ettinger B, Rubinoff H, Ettinger VM, Minkoff J, Hom F, Kan P, Alloo R (1996) Prevalence of hypothalamic-pituitary imaging abnormalities in impotent men with secondary hypogonadism. J Urol 155:529–533

    Article  CAS  PubMed  Google Scholar 

  14. Boloña ER, Uraga MV, Haddad RM, Tracz MJ, Sideras K, Kennedy CC, Caples SM, Erwin PJ, Montori VM (2007) Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc 82:20–28

    Article  PubMed  Google Scholar 

  15. Shabsigh R, Kaufman JM, Steidle C, Padma-Nathan H (2004) Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J Urol 172:658–663

    Article  CAS  PubMed  Google Scholar 

  16. Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S (2005) Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 60:1451–1457

    Article  PubMed  Google Scholar 

  17. Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, Eder R, Tennstedt S, Ulloor J, Zhang A, Choong K, Lakshman KM, Mazer NA, Miciek R, Krasnoff J, Elmi A, Knapp PE, Brooks B, Appleman E, Aggarwal S, Bhasin G, Hede-Brierley L, Bhatia A, Collins L, LeBrasseur N, Fiore LD, Bhasin S (2010) Adverse events associated with testosterone administration. N Engl J Med 363:109–122

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Vigen R, O’Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM (2013) Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 310:1829–1836

    Article  CAS  PubMed  Google Scholar 

  19. Bhasin S, Enzlin P, Coviello A, Basson R (2007) Sexual dysfunction in men and women with endocrine disorders. Lancet 369:597–611

    Article  CAS  PubMed  Google Scholar 

  20. De Rosa M, Zarrilli S, Vitale G, Di Somma C, Orio F, Tauchmanova’ L, Lombardi G, Colao A (2004) Six months of treatment with cabergoline restores sexual potency in hyperprolactinemic males: an open longitudinal study monitoring nocturnal penile tumescence. J Clin Endocrinol Metab 89:621–625

    Article  PubMed  Google Scholar 

  21. Delavierre D, Girard P, Peneau M, Ibrahim H (1999) Should plasma prolactin assay be routinely performed in the assessment of erectile dysfunction? Report of a series of 445 patients. Review of the literature. Prog Urol 9:1097–1101

    CAS  PubMed  Google Scholar 

  22. Slag MF, Morley JE, Elson MK, Trence DL, Nelson CJ, Nelson AE, Kinlaw WB, Beyer HS, Nuttall FQ, Shafer RB (1983) Impotence in medical clinic outpatients. JAMA 249:1736–1740

    Article  CAS  PubMed  Google Scholar 

  23. Krassas GE, Tziomalos K, Papadopoulou F, Pontikides N, Perros P (2008) Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat? J Clin Endocrinol Metab 93:1815–1819

    Article  CAS  PubMed  Google Scholar 

  24. Krassas GE, Poppe K, Glinoer D (2010) Thyroid function and human reproductive health. Endocr Rev 31:702–755

    Article  CAS  PubMed  Google Scholar 

  25. Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, Jannini EA (2005) Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab 90:6472–6479

    Article  CAS  PubMed  Google Scholar 

  26. Soran H, Wu FC (2005) Endocrine causes of erectile dysfunction. Int J Androl 28(Suppl 2):28–34

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Vasilios G. Athyros .

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Tziomalos, K., Athyros, V.G. (2015). Endocrine Disorders and Erectile Dysfunction. In: Viigimaa, M., Vlachopoulos, C., Doumas, M. (eds) Erectile Dysfunction in Hypertension and Cardiovascular Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-08272-1_14

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  • DOI: https://doi.org/10.1007/978-3-319-08272-1_14

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