Abstract
The main tool in nuclear medicine is ionizing radiation; therefore, it is important for its users to be familiar with its biological effects and pathophysiological basis. Ionization is the process of ion production by ejection of electrons from atoms and molecules after exposure to high temperature, electrical discharges, or electromagnetic and nuclear radiation. Ionizing radiation is subdivided into electromagnetic radiation (X-rays and gamma rays) and particulate radiation including neutrons and charged particles (alpha and beta particles).
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References
United Nations Environment Program (1988) Radiation: doses, effects, risks. Blackwell, Oxford, pp 65–84
Cotran RS, Kumar V, Collins T (2010) Robbins pathologic basis of disease, 8th edn. W.B. Saunders, Philadelphia
Prasad KN (1995) Handbook of radiobiology, 2nd edn. CRC Press, Boca Raton
Azzam EI, de Toledo SM, Little JB (2001) Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proc Natl Acad Sci U S A 98(2):473–478
Ramesh R, Marrogi AJ, Munshi A, Abboud CN, Freeman SM (1996) In vivo analysis of the ‘bystander effect’: a cytokine cascade. Exp Hematol 24(7):829–838
Iyer R, Lehnert BE (2000) Factors underlying the cell growth-related bystander responses to particles. Cancer Res 60:1290–1298
Morgan WF (2003) Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res 59(5):581–596
Suzuki K, Ojima M, Kodama S, Watanabe M (2003) Radiation-induced DNA damage and delayed induced genomic instability. Oncogene 22(45):6988–6993
Kendall GM (2000) Second-event theory reviewed. J Radiol Prot 20(1):79–80
Ward JF (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog Nucleic Acid Res Mol Biol 35:95
Bolus NE (2001) Basic review of radiation biology and terminology. J Nucl Med Technol 29:67–73
Ernest M, Freed ME, Zametkin AJ (1996) Health hazards of radiation exposure in the context of brain imaging research: special consideration for children. J Nucl Med 39:689–698
Johansson L (2003) Hormesis, an update of the present position. Eur J Nucl Med Mol Imaging 30:921–933
Feinendegen LE (2005) Low doses of ionizing radiation: relationship between biological benefit and damage induction. A synopsis. World J Nucl Med 4:21–34
Feinenegen LE (2005) Evidence for beneficial low level radiation effects and radiation hormesis. Br J Radiol 78(925):3–7
Holm I, Hall P, Wiklund K et al (1991) Cancer risk after iodine-131 therapy for hyperthyroidism. J Natl Cancer Inst 83:1072
Saenger EL, Thomas GE, Tompkins EA (1968) Incidence of leukemia following treatment of hyperthyroidism. Preliminary report of the cooperative thyrotoxicosis therapy follow-up study. JAMA 205:855
Matanoski GM (1991) Health effects of low-level radiation in shipyard workers: final report. DOE DE-AC0279 EV10095
Cameron J (1992) The good news about low-level radiation exposure: health effects of low-level radiation in shipyard workers. Health Phys Soc Newslett 20:9
Billen D (1990) Spontaneous DNA damage and its significance for the “negligible dose” controversy in radiation protection. Radiat Res 124:242
Ward JF (1987) Radiation chemical methods of cell death. In: Fielden EM, Fowler JF, Hendry JH, Scott D (eds) Proceedings of the 8th international congress of radiation research, vol II. Taylor and Francis, London, pp 162–168
Quingyi W (1993) DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc Natl Acad Sci U S A 90:1614
Koshland DE, Sancar A, Hanawalt PC, Modrich P (1994) DNA repair enzymes and mechanisms. Science 266:1925–1927
Kneala GW, Sterwart AM (1976) Mantil-Haenzel analysis of Oxford data. II. Independent effects of fetal irradiation subfactors. J Natl Cancer Inst 57:1009
Committee on the Biological Effects of Ionizing Radiations (1980) The effects on population of exposure to low levels of ionizing radiation. National Academic Press, Washington DC
International Commission on Radiological Protection, Radiosensitivity and Spatial Distribution of Dose (1969) Publication no 14. Pergamon, Oxford
Dodo T (1975) Cataract. J Radiat Res Suppl 16:132
Khamwan K, Krisanachinda A, Pasawang P (2010) The determination of patient dose from 18F-FDG PET/CT examination. Radiat Prot Dosimetry 141:50–55
Brix G, Lechel U, Glatting G, Ziegler SI, Münzing W, Müller SP, Beyer T (2005) Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations. J Nucl Med 46:608–613
UNSCEAR 2008 Report. Sources and effects of ionizing radiation, United Nations Scientific Committee on the effects of atomic radiation, New York, 2010
Cohen BL (1995) Test of the linear-no threshold theory of radiation carcinogenesis in the low dose rate region. Health Phys 68:157
UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) (1994) Annex B: adaptive responses to radiation in cells and organisms. Document A/Ac. 82/R.542, approved 11 March 1994
High Background radiation research group (1980) Health survey in high background radiation areas in China. Science 209:877–880
Nambi KS, Soman SD (1987) Environmental radiation and cancer in India. Health Phys 52:653–657
Ghiassi-nejad M, Mortazavi SMJ, Cameron JR, Niroomand-Rad A, Karam PA (2002) Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys 82:87–93
Jagger J (1998) Natural background radiation and cancer death in Rocky Mountain states and Gulf Coast states. Health Phys 75:428–430
Cohen BJ (1995) Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon products. Health Phys 68:157–174
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Elgazzar, A.H., Kazem, N. (2015). Biological Effects of Ionizing Radiation. In: Elgazzar, A. (eds) The Pathophysiologic Basis of Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06112-2_21
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