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Alternative Interventional Study Designs

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Essentials of Clinical Research

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Abstract

There are many variations to the classical randomized controlled trial. These variations are utilized when, for a variety of reasons, the classical randomized controlled trial would be impossible, inappropriate, or impractical. Some of the variations are described in this chapter and include: equivalence and non-inferiority trials; crossover trials; N of 1 trials, case-crossover trials, and externally controlled trials. Large simple trials, and prospective randomized, open-label, blinded endpoint trials are discussed in another chapter.

A man who does not habitually wonder is but a pair of spectacles behind which there is no eye (Thomas Carlyle) [1]

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  1. Division of Preventive Medicine, University of Alabama at Birmingham, 1717 11th Ave S MT638, Birmingham, AL, 35205, USA

    Stephen P. Glasser M.D.

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  1. Stephen P. Glasser M.D.
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Correspondence to Stephen P. Glasser M.D. .

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  1. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Stephen P. Glasser

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Glasser, S.P. (2014). Alternative Interventional Study Designs. In: Glasser, S. (eds) Essentials of Clinical Research. Springer, Cham. https://doi.org/10.1007/978-3-319-05470-4_4

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  • DOI: https://doi.org/10.1007/978-3-319-05470-4_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-05469-8

  • Online ISBN: 978-3-319-05470-4

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