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Application of MicroRNA in the Treatment and Diagnosis of Cervical Cancer

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Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules of 20–23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan

    Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Kanako Nakamura, Masataka Adachi, Takashi Iwata, Kyoko Tanaka & Daisuke Aoki

Authors
  1. Kouji Banno
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  2. Miho Iida
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  3. Megumi Yanokura
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  4. Iori Kisu
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  5. Kanako Nakamura
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  6. Masataka Adachi
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  7. Takashi Iwata
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  8. Kyoko Tanaka
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  9. Daisuke Aoki
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Corresponding author

Correspondence to Kouji Banno .

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Editors and Affiliations

  1. Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Fazlul H. Sarkar

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© 2014 Springer International Publishing Switzerland

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Banno, K. et al. (2014). Application of MicroRNA in the Treatment and Diagnosis of Cervical Cancer. In: Sarkar, F. (eds) MicroRNA Targeted Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-05134-5_7

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