Abstract
For addition of HX to olefins, Markovnikov’s Rule predicts the regiochemistry of HX addition to unsymmetrically substituted alkenes: The halide component of HX bonds preferentially at the more highly substituted carbon, whereas the hydrogen prefers the carbon which already contains more hydrogen atoms.
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References
Markownikoff, W. Ann. Pharm. 1870, 153, 228–259. Vladimir Vasilyevich Markovnikov (1838–1904) fomulated the rule for addition to alkenes at Moscow University. He was one of the most eminant Russian organic chemists in the 19th century. He was a prickly individual with strong opinions, and he had no fear in expressing them. His tactless outspokenness led to his ouster from professorship at Kazan’ and Moscow. (Lewis, D. E. Early Russian Organic Chemists and Their Legacy, Springer: Heldelberg, Germany, 2012, p 71.).
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Li, J.J. (2014). Markovnikov’s rule. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_163
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DOI: https://doi.org/10.1007/978-3-319-03979-4_163
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