Abstract
Determining disease-related variations of the anatomy and function is an important step in better understanding diseases and developing early diagnostic systems. In particular, image-based multivariate prediction models and the “relevant features” they produce are attracting attention from the community. In this article, we present an empirical study on the relevant features produced by two recently developed discriminative learning algorithms: neighborhood approximation forests (NAF) and the relevance voxel machine (RVoxM). Specifically, we examine whether the sets of features these methods produce are exhaustive; that is whether the features that are not marked as relevant carry disease-related information. We perform experiments on three different problems: image-based regression on a synthetic dataset for which the set of relevant features is known, regression of subject age as well as binary classification of Alzheimer’s Disease (AD) from brain Magnetic Resonance Imaging (MRI) data. Our experiments demonstrate that aging-related and AD-related variations are widespread and the initial sets of relevant features discovered by the methods are not exhaustive. Our findings show that by knocking-out features and re-training models, a much larger set of disease-related features can be identified.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sabuncu, M., Van Leemput, K.: The relevance voxel machine (rvoxm): A self-tuning bayesian model for informative image-based prediction. IEEE Transactions on Medical Imaging 31(12), 2290–2306 (2012)
Gaonkar, B., Davatzikos, C.: Deriving statistical significance maps for svm based image classification and group comparisons. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012, Part I. LNCS, vol. 7510, pp. 723–730. Springer, Heidelberg (2012)
Konukoglu, E., Glocker, B., Zikic, D., Criminisi, A.: Neighbourhood approximation using randomized forests. Medical Image Analysis (2013)
Marcus, D., Wang, T., Parker, J., Csernansky, J., Morris, J., Buckner, R.: Open access series of imaging studies (oasis): cross-sectional mri data in young, middle aged, nondemented, and demented older adults. Journal of Cognitive Neuroscience 19(9), 1498–1507 (2007)
Good, P.I.: Permutation, parametric and bootstrap tests of hypotheses. Springer Science+Business Media (2005)
Amit, Y., Geman, D.: Shape quantization and recognition with randomized trees. Neural Computation 9(7), 1545–1588 (1997)
Strobl, C., Boulesteix, A.L., Zeileis, A., Hothorn, T.: Bias in random forest variable importance measures: Illustrations, sources and a solution. BMC Bioinformatics 8(1) 25 (2007)
Dale, A.M., Fischl, B., Sereno, M.I.: Cortical surface-based analysis: I. Segmentation and surface reconstruction. Neuroimage 9(2), 179–194 (1999)
Fischl, B., Sereno, M.I., Dale, A.M.: Cortical surface-based analysis ii: Inflation, flattening, and a surface-based coordinate system. Neuroimage 9(2), 195–207 (1999)
Fischl, B., Dale, A.M.: Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences 97(20), 11050–11055 (2000)
Fischl, B., Sereno, M.I., Tootell, R.B., Dale, A.M., et al.: High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping 8(4), 272–284 (1999)
Author information
Authors and Affiliations
Consortia
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer International Publishing Switzerland
About this paper
Cite this paper
Konukoglu, E., Ganz, M., Van Leemput, K., Sabuncu, M.R., for the Alzheimers Disease Neuroimaging Initiative. (2013). On Feature Relevance in Image-Based Prediction Models: An Empirical Study. In: Wu, G., Zhang, D., Shen, D., Yan, P., Suzuki, K., Wang, F. (eds) Machine Learning in Medical Imaging. MLMI 2013. Lecture Notes in Computer Science, vol 8184. Springer, Cham. https://doi.org/10.1007/978-3-319-02267-3_22
Download citation
DOI: https://doi.org/10.1007/978-3-319-02267-3_22
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-02266-6
Online ISBN: 978-3-319-02267-3
eBook Packages: Computer ScienceComputer Science (R0)