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Atresia or Stenosis of the Alimentary Tract

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Epidemiology of Human Congenital Malformations

Abstract

Three types of alimentary tract atresia were studied: oesophageal (n= 360), small gut (n=253), and anal (n=457) atresia or stenosis. No association with maternal age was seen but there was a higher risk at parity 1 than at higher parities. Maternal overweight or obesity increased the risk for all three types of atresia while a period of unwanted childlessness increased the risk for small gut atresia while previous miscarriage was associated with an increased risk for oesophageal but not for small gut atresia. Maternal use of systemic glucocorticosteroids increased the risk for any atresia and use of thyroxine may result in an increased risk of anal atresia.

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References

  • Blomberg MI, Källén B. Maternal obesity and morbid obesity: the risk for birth defects in the offspring. Birth Defects Res A. 2010;88:35–40.

    CAS  Google Scholar 

  • Duong HT, Hoyt AT, Carmichael SL, Gilboa SM, Canfield MA, Case A, McNeese ML, Waller DK, National Birth Defects Prevention Study. Is maternal parity an independent risk factor for birth defects? Birth Defects Res A. 2012;94:230–6.

    Article  CAS  Google Scholar 

  • Hackshaw A, Rodeck C, Boniface S. Maternal smoking in pregnancy and birth defects: a systematic review based on 173687 malformed cases and 11.7 million controls. Hum Reprod Update. 2011;17:589–604.

    Article  PubMed  CAS  Google Scholar 

  • Harris J, Källén B, Robert E. Descriptive epidemiology of alimentary tract atresia. Teratology. 1995;52:15–29.

    Article  PubMed  CAS  Google Scholar 

  • Kirillova LA, Kulazhenko VP, Lurie TW, Ljazjuk GI. Atresia, stenosis and duplication of the gastro-intestinal tract: consideration of their origin. Acta Morphol Hung. 1984;32:9–21.

    PubMed  CAS  Google Scholar 

  • Lisi A, Botto LD, Rittler M, Castilla E, Bianchi F, Botting B, De Walle H, Erickson JD, Gatt M, De Vigan C, Irgens L, Johnson W, Lancaster P, Merlob P, Mutchinick OM, Ritvanen A, Robert E, Scarano G, Stoll C, Mastroiacovo P. Sex and congenital malformations: an international perspective. Am J Med Genet. 2005;134A:49–57.

    Article  PubMed  Google Scholar 

  • Nassar N, Leoncini E, Amar A, Arteaga-Vázquez J, Bakker MK, Bowen C, Canfield MA, Castilla EE, Cochi G, Correa A, Csáky-Szunyogh M, Feldkamp ML, Khoshnood B, Landau D, Lelong N, López-Camelo JS, Lowry RB, McDonell R, Merlob P, Métneki J, Morgan M, Mutchinick OM, Palmer MN, Rissman A, Siffel C, Sìpek A, Szabova E, Tucker D, Mastroiacovo P. Prevalence of esophageal atresia among 18 international birth defects surveillance programs. Birth Def Res A. 2012;94:893–9.

    Article  CAS  Google Scholar 

  • Norstedt Wikner B, Stiller C-O, Bergman U, Asker C, Källén B. Use of benzodiazepinea and benzodiazepine receptor agonists during pregnancy: neonatal outcome and congenital malformations. Pharmacoepidemiol Drug Saf. 2007;16:1203–10.

    Article  Google Scholar 

  • Puri P, Fujimoto T. New observations on the pathogenesis of multiple intestinal atresias. J Pediatr Surg. 1988;23:221–5.

    Article  PubMed  CAS  Google Scholar 

  • Zwink N, Jenetsky E, Bremer H. Parental risk factors and anorectal malformations: systematic review and meta-analysis. Orphanet J Rare Dis. 2011;6:25. doi:10.1188/1750ö1172-6-25.

    Article  PubMed  Google Scholar 

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Källén, B. (2014). Atresia or Stenosis of the Alimentary Tract. In: Epidemiology of Human Congenital Malformations. Springer, Cham. https://doi.org/10.1007/978-3-319-01472-2_14

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  • DOI: https://doi.org/10.1007/978-3-319-01472-2_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-01471-5

  • Online ISBN: 978-3-319-01472-2

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